Search Results - "Patrik Verstreken"

Autophagy in the presynaptic compartment in health and disease by Vijayan, Vinoy, Verstreken, Patrik

“…Synapses are functionally distinct neuronal compartments that are critical for brain function, with synaptic dysfunction being an early pathological feature in…”
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Loss of Bin1 Promotes the Propagation of Tau Pathology by Calafate, Sara, Flavin, William, Verstreken, Patrik, Moechars, Diederik

“…Tau pathology propagates within synaptically connected neuronal circuits, but the underlying mechanisms are unclear. BIN1-amphiphysin2 is the second most…”
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Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila by Cornelissen, Tom, Vilain, Sven, Vints, Katlijn, Gounko, Natalia, Verstreken, Patrik, Vandenberghe, Wim

“…Mutations in the genes for PINK1 and parkin cause Parkinson's disease. PINK1 and parkin cooperate in the selective autophagic degradation of damaged…”
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A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain by Davie, Kristofer, Janssens, Jasper, Koldere, Duygu, De Waegeneer, Maxime, Pech, Uli, Kreft, Łukasz, Aibar, Sara, Makhzami, Samira, Christiaens, Valerie, Bravo González-Blas, Carmen, Poovathingal, Suresh, Hulselmans, Gert, Spanier, Katina I., Moerman, Thomas, Vanspauwen, Bram, Geurs, Sarah, Voet, Thierry, Lammertyn, Jeroen, Thienpont, Bernard, Liu, Sha, Konstantinides, Nikos, Fiers, Mark, Verstreken, Patrik, Aerts, Stein

“…The diversity of cell types and regulatory states in the brain, and how these change during aging, remains largely unknown. We present a single-cell…”
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ER Lipid Defects in Neuropeptidergic Neurons Impair Sleep Patterns in Parkinson’s Disease by Valadas, Jorge S., Esposito, Giovanni, Vandekerkhove, Dirk, Miskiewicz, Katarzyna, Deaulmerie, Liesbeth, Raitano, Susanna, Seibler, Philip, Klein, Christine, Verstreken, Patrik

“…Parkinson’s disease patients report disturbed sleep patterns long before motor dysfunction. Here, in parkin and pink1 models, we identify circadian rhythm and…”
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Tau association with synaptic vesicles causes presynaptic dysfunction by Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik

“…Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease. Under pathological conditions, Tau dissociates from axonal…”
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PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling by Morais, Vanessa A., Haddad, Dominik, Craessaerts, Katleen, De Bock, Pieter-Jan, Swerts, Jef, Vilain, Sven, Aerts, Liesbeth, Overbergh, Lut, Grünewald, Anne, Seibler, Philip, Klein, Christine, Gevaert, Kris, Verstreken, Patrik, De Strooper, Bart

“…Under resting conditions, Pink1 knockout cells and cells derived from patients with PINK1 mutations display a loss of mitochondrial complex I reductive…”
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Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy by Uytterhoeven, Valerie, Lauwers, Elsa, Maes, Ine, Miskiewicz, Katarzyna, Melo, Manuel N., Swerts, Jef, Kuenen, Sabine, Wittocx, Rafaël, Corthout, Nikky, Marrink, Siewert-Jan, Munck, Sebastian, Verstreken, Patrik

“…Synapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress. To…”
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Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation by Calafate, Sara, Buist, Arjan, Miskiewicz, Katarzyna, Vijayan, Vinoy, Daneels, Guy, de Strooper, Bart, de Wit, Joris, Verstreken, Patrik, Moechars, Diederik

“…Accumulation of insoluble Tau protein aggregates and stereotypical propagation of Tau pathology through the brain are common hallmarks of tauopathies,…”
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The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals by Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T, de Vrij, Femke MS, Kushner, Steven A, Gounko, Natalia V, Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A, Soukup, Sandra‐Fausia, Verstreken, Patrik

“…Presynaptic terminals are metabolically active and accrue damage through continuous vesicle cycling. How synapses locally regulate protein homeostasis is…”
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Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation by Aragão Gomes, Luis, Uytterhoeven, Valerie, Lopez-Sanmartin, Diego, Tomé, Sandra O., Tousseyn, Thomas, Vandenberghe, Rik, Vandenbulcke, Mathieu, von Arnim, Christine A. F., Verstreken, Patrik, Thal, Dietmar Rudolf

“…In Alzheimer’s disease (AD), tau-protein undergoes a multi-step process involving the transition from a natively unfolded monomer to large, aggregated…”
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Presynaptic Autophagy and the Connection With Neurotransmission by Decet, Marianna, Verstreken, Patrik

“…Autophagy is an evolutionary conserved catabolic pathway essential for the maintenance of cellular homeostasis. Defective proteins and organelles are engulfed…”
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Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease by Vos, Melissa, Lauwers, Elsa, Verstreken, Patrik

“…Cell types rich in mitochondria, including neurons, display a high energy demand and a need for calcium buffering. The importance of mitochondria for proper…”
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In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters by Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno, Meunier, Frédéric A.

“…Syntaxin1A is organized in nanoclusters that are critical for the docking and priming of secretory vesicles from neurosecretory cells. Whether and how these…”
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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism by Arranz, Amaia M, Delbroek, Lore, Van Kolen, Kristof, Guimarães, Marco R, Mandemakers, Wim, Daneels, Guy, Matta, Samer, Calafate, Sara, Shaban, Hamdy, Baatsen, Pieter, De Bock, Pieter-Jan, Gevaert, Kris, Vanden Berghe, Pieter, Verstreken, Patrik, De Strooper, Bart, Moechars, Diederik

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains…”
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Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System by Murdoch, John D., Rostosky, Christine M., Gowrisankaran, Sindhuja, Arora, Amandeep S., Soukup, Sandra-Fausia, Vidal, Ramon, Capece, Vincenzo, Freytag, Siona, Fischer, Andre, Verstreken, Patrik, Bonn, Stefan, Raimundo, Nuno, Milosevic, Ira

“…Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here…”
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Mitochondria at the Synapse by Ly, Cindy V., Verstreken, Patrik

“…Synapses are packed with mitochondria, complex organelles with roles in energy metabolism, cell signaling, and calcium homeostasis. However, the precise…”
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MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome by Thues, Cedric, Valadas, Jorge S., Deaulmerie, Liesbeth, Geens, Ann, Chouhan, Amit K., Duran-Romaña, Ramon, Schymkowitz, Joost, Rousseau, Frederic, Bartusel, Michaela, Rehimi, Rizwan, Rada-Iglesias, Alvaro, Verstreken, Patrik, Van Esch, Hilde

“…Circumferential skin creases (CSC-KT) is a rare polymalformative syndrome characterised by intellectual disability associated with skin creases on the limbs,…”
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Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification by Dejonghe, Wim, Kuenen, Sabine, Mylle, Evelien, Vasileva, Mina, Keech, Olivier, Viotti, Corrado, Swerts, Jef, Fendrych, Matyáš, Ortiz-Morea, Fausto Andres, Mishev, Kiril, Delang, Simon, Scholl, Stefan, Zarza, Xavier, Heilmann, Mareike, Kourelis, Jiorgos, Kasprowicz, Jaroslaw, Nguyen, Le Son Long, Drozdzecki, Andrzej, Van Houtte, Isabelle, Szatmári, Anna-Mária, Majda, Mateusz, Baisa, Gary, Bednarek, Sebastian York, Robert, Stéphanie, Audenaert, Dominique, Testerink, Christa, Munnik, Teun, Van Damme, Daniël, Heilmann, Ingo, Schumacher, Karin, Winne, Johan, Friml, Jiří, Verstreken, Patrik, Russinova, Eugenia

“…ATP production requires the establishment of an electrochemical proton gradient across the inner mitochondrial membrane. Mitochondrial uncouplers dissipate…”
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Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration by Fernandes, Ana Clara, Uytterhoeven, Valerie, Kuenen, Sabine, Wang, Yu-Chun, Slabbaert, Jan R, Swerts, Jef, Kasprowicz, Jaroslaw, Aerts, Stein, Verstreken, Patrik

“…Synaptic demise and accumulation of dysfunctional proteins are thought of as common features in neurodegeneration. However, the mechanisms by which synaptic…”
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