Search Results - "Patrick S. Covello"

Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants by Chekan, Jonathan R., Estrada, Paola, Covello, Patrick S., Nair, Satish K.

“…Enzymes that can catalyze the macrocyclization of linear peptide substrates have long been sought for the production of libraries of structurally diverse…”
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The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin in Artemisia annua by Zhang, Yansheng, Teoh, Keat H., Reed, Darwin W., Maes, Lies, Goossens, Alain, Olson, Douglas J.H., Ross, Andrew R.S., Covello, Patrick S.

“…At some point during biosynthesis of the antimalarial artemisinin in glandular trichomes of Artemisia annua, the Δ11(13) double bond originating in…”
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Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest by Xiao, Mei, Zhang, Ye, Chen, Xue, Lee, Eun-Jeong, Barber, Carla J.S., Chakrabarty, Romit, Desgagné-Penix, Isabel, Haslam, Tegan M., Kim, Yeon-Bok, Liu, Enwu, MacNevin, Gillian, Masada-Atsumi, Sayaka, Reed, Darwin W., Stout, Jake M., Zerbe, Philipp, Zhang, Yansheng, Bohlmann, Joerg, Covello, Patrick S., De Luca, Vincenzo, Page, Jonathan E., Ro, Dae-Kyun, Martin, Vincent J.J., Facchini, Peter J., Sensen, Christoph W.

“…•Developed data-mining framework to study plant specialized metabolism.•Compared two next-generation sequencing technologies.•Assigned functional information…”
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Molecular cloning of an ester-forming triterpenoid: UDP-glucose 28-O-glucosyltransferase involved in saponin biosynthesis from the medicinal plant Centella asiatica by de Costa, Fernanda, Barber, Carla J.S., Kim, Yeon-bok, Reed, Darwin W., Zhang, Haixia, Fett-Neto, Arthur G., Covello, Patrick S.

“…[Display omitted] •Centella asiatica contains bioactive ursane triterpenoid saponins.•C. asiatica cDNA encoding a triterpenoid UDP-glucosyltransferase (UGT)…”
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The Two-step Biosynthesis of Cyclic Peptides from Linear Precursors in a Member of the Plant Family Caryophyllaceae Involves Cyclization by a Serine Protease-like Enzyme by Barber, Carla J.S., Pujara, Pareshkumar T., Reed, Darwin W., Chiwocha, Shiela, Zhang, Haixia, Covello, Patrick S.

“…Caryophyllaceae-type cyclic peptides (CPs) of 5–12 proteinogenic amino acids occur in 10 plant families. In Saponaria vaccaria (Caryophyllaceae), they have…”
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Synthetic biosystems for the production of high-value plant metabolites by Facchini, Peter J, Bohlmann, Joerg, Covello, Patrick S, De Luca, Vincenzo, Mahadevan, Radhakrishnan, Page, Jonathan E, Ro, Dae-Kyun, Sensen, Christoph W, Storms, Reginald, Martin, Vincent J.J

“…Plants display an immense diversity of specialized metabolites, many of which have been important to humanity as medicines, flavors, fragrances, pigments,…”
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Artemisinin production in Artemisia annua: studies in planta and results of a novel delivery method for treating malaria and other neglected diseases by Weathers, Pamela J., Arsenault, Patrick R., Covello, Patrick S., McMickle, Anthony, Teoh, Keat H., Reed, Darwin W.

“…Artemisia annua L. produces the sesquiterpene lactone, artemisinin, a potent antimalarial drug that is also effective in treating other parasitic diseases,…”
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Functional genomics and the biosynthesis of artemisinin by Covello, Patrick S., Teoh, Keat H., Polichuk, Devin R., Reed, Darwin W., Nowak, Goska

“…The biosynthesis in Artemisia annua glandular trichomes of the antimalarial sesquiterpene artemisinin is reviewed with emphasis on recent functional genomics…”
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biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors by Condie, Janet A, Nowak, Goska, Reed, Darwin W, Balsevich, J. John, Reaney, Martin J.T, Arnison, Paul G, Covello, Patrick S

“…Cyclic peptides (CPs) are produced in a very wide range of taxa. Their biosynthesis generally involves either non-ribosomal peptide synthases or…”
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Primary Structure, Regioselectivity, and Evolution of the Membrane-bound Fatty Acid Desaturases of Claviceps purpurea by Meesapyodsuk, Dauenpen, Reed, Darwin W., Covello, Patrick S., Qiu, Xiao

“…Two cDNAs with sequence similarity to fatty acid desaturase genes were isolated from the phytopathogenic fungus, Claviceps purpurea. The predicted amino acid…”
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A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua by Polichuk, Devin R., Zhang, Yansheng, Reed, Darwin W., Schmidt, Janice F., Covello, Patrick S.

“…Cloning and characterization of a trichome-specific alcohol dehydrogenase from Artemisia annua is described that preferentially oxidizes monoterpenoid…”
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Seed-Specific Over-Expression of an Arabidopsis cDNA Encoding a Diacylglycerol Acyltransferase Enhances Seed Oil Content and Seed Weight by Colette Jako, Kumar, Arvind, Yangdou Wei, Zou, Jitao, Dennis L. Barton, Giblin, E. Michael, Patrick S. Covello, Taylor, David C.

“…We recently reported the cloning and characterization of an Arabidopsis (ecotype Columbia) diacylglycerol acyltransferase cDNA (Zou et al., 1999) and found…”
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Making artemisinin by Covello, Patrick S.

“…The possibilities for the production of the antimalarial artemisinin by biological and chemical synthesis are explored. The possibilities for the production of…”
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High-Level Production of γ-Linolenic Acid in Brassica juncea Using a Δ6 Desaturase from Pythium Irregulare by HAIPING HONG, DATLA, Nagamani, REED, Darwin W, COVELLO, Patrick S, MACKENZIE, Samuel L, XIAO QIU

“…γ-Linolenic acid (GLA), a nutritionally important fatty acid in mammals, is synthesized by a Δ6 desaturase. Here, we report identification of PiD6, a new cDNA…”
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Topological Study of Mechanistic Diversity in Conjugated Fatty Acid Biosynthesis by Bhar, Palash, Reed, Darwin W., Covello, Patrick S., Buist, Peter H.

“…Variations on an oxidative theme: The precision with which FAD2‐type desaturases carry out CH activation reactions on flexible lipidic substrates is…”
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Structural Control of Chemoselectivity, Stereoselectivity, and Substrate Specificity in Membrane-Bound Fatty Acid Acetylenases and Desaturases by Gagné, Steve J, Reed, Darwin W, Gray, Gordon R, Covello, Patrick S

“…The FAD2-like desaturases comprise a group of membrane-bound oxygenases involved in the modification of fatty acyl groups in plants and fungi. This group…”
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Saponin Biosynthesis in Saponaria vaccaria. cDNAs Encoding β-Amyrin Synthase and a Triterpene Carboxylic Acid Glucosyltransferase by Meesapyodsuk, Dauenpen, Balsevich, John, Reed, Darwin W, Covello, Patrick S

“…Saponaria vaccaria (Caryophyllaceae), a soapwort, known in western Canada as cowcockle, contains bioactive oleanane-type saponins similar to those found in…”
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Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants by Maes, Lies, Van Nieuwerburgh, Filip C.W, Zhang, Yansheng, Reed, Darwin W, Pollier, Jacob, Vande Casteele, Sofie R.F, Inzé, Dirk, Covello, Patrick S, Deforce, Dieter L.D, Goossens, Alain

“…• Biosynthesis of the sesquiterpene lactone and potent antimalarial drug artemisinin occurs in glandular trichomes of Artemisia annua plants and is subjected…”
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Artemisia annua L. (Asteraceae) trichome-specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin by Teoh, Keat H., Polichuk, Devin R., Reed, Darwin W., Nowak, Goska, Covello, Patrick S.

“…Artemisinin, a sesquiterpene lactone endoperoxide derived from the plant Artemisia annua, forms the basis of the most important treatments of malaria in use…”
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Characterization of the Brassica napus Extraplastidial Linoleate Desaturase by Expression in Saccharomyces cerevisiae by REED, D. W, SCHÄFER, U. A, COVELLO, P. S

“…The substrate specificity and regioselectivity of the Brassica napus extraplastidial linoleate desaturase (FAD3) was investigated in vivo in a heterologous…”
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