Search Results - "Patrick J. Branigan"

Guselkumab Reduces Disease- and Mechanism-Related Biomarkers More Than Adalimumab in Patients with Psoriasis: A VOYAGE 1 Substudy by Blauvelt, Andrew, Langley, Richard G., Branigan, Patrick J., Liu, Xuejun, Chen, Yanqing, DePrimo, Samuel, Ma, Keying, Scott, Brittney, Campbell, Kim, Muñoz-Elías, Ernesto J., Papp, Kim A.

“…Psoriasis is an immune-mediated inflammatory disease characterized by activation of IL-23–driven IL-17–producing T cell and other IL-23 receptor–positive…”
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Integrating personalized gene expression profiles into predictive disease-associated gene pools by Menche, Jörg, Guney, Emre, Sharma, Amitabh, Branigan, Patrick J., Loza, Matthew J., Baribaud, Frédéric, Dobrin, Radu, Barabási, Albert-László

“…Gene expression data are routinely used to identify genes that on average exhibit different expression levels between a case and a control group. Yet, very few…”
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Differential Pharmacodynamic Effects on Psoriatic Biomarkers by Guselkumab Versus Secukinumab Correlate with Long-Term Efficacy: An ECLIPSE Substudy by Blauvelt, Andrew, Chen, Yanqing, Branigan, Patrick J., Liu, Xuejun, DePrimo, Samuel, Keyes, Brice E., Leung, Monica, Fakharzadeh, Steven, Yang, Ya-Wen, Muñoz-Elías, Ernesto J., Krueger, James G., Langley, Richard G.

“…IL-23 is a cytokine produced by myeloid cells that drives the T helper 17 pathway and plays an essential role in the pathophysiology of plaque psoriasis. IL-23…”
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TLR3 activation stimulates cytokine secretion without altering agonist-induced human small airway contraction or relaxation by Cooper, Philip R, Lamb, Roberta, Day, Nicole D, Branigan, Patrick J, Kajekar, Radhika, San Mateo, Lani, Hornby, Pamela J, Panettieri, Jr, Reynold A

“…Respiratory infections exacerbate chronic lung diseases promoting airway inflammation and hyperreactivity. Toll-like receptor 3 (TLR3) recognizes viral…”
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Local production of inflammatory mediators during childhood parainfluenza virus infection by El Feghaly, Rana E, McGann, Lindsay, Bonville, Cynthia A, Branigan, Patrick J, Suryadevera, Manika, Rosenberg, Helene F, Domachowske, Joseph B

“…To describe the clinical manifestations of parainfluenza virus (PIV) infection and to characterize biochemical markers of PIV disease severity. We reviewed the…”
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Clinical Features, Adenovirus Types, and Local Production of Inflammatory Mediators in Adenovirus Infections by MORO, Maria R, BONVILLE, Cynthia A, SURYADEVARA, Manika, CUMMINGS, Erin, FADDOUL, Diala, KOBAYAA, Hazar, BRANIGAN, Patrick J, DOMACHOWSKE, Joseph B

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Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function by Day, Nicole D, Branigan, Patrick J, Liu, Changbao, Gutshall, Lester L, Luo, Jianquan, Melero, José A, Sarisky, Robert T, Del Vecchio, Alfred M

“…The mature F protein of all known isolates of human respiratory syncytial virus (HRSV) contains fifteen absolutely conserved cysteine (C) residues that are…”
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Use of a novel cell-based fusion reporter assay to explore the host range of human respiratory syncytial virus F protein by Branigan, Patrick J, Liu, Changbao, Day, Nicole D, Gutshall, Lester L, Sarisky, Robert T, Del Vecchio, Alfred M

“…Human respiratory syncytial virus (HRSV) is an important respiratory pathogen primarily affecting infants, young children, transplant recipients and the…”
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Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus by Liu, Changbao, Day, Nicole D, Branigan, Patrick J, Gutshall, Lester L, Sarisky, Robert T, Del Vecchio, Alfred M

“…To elucidate the relationship between resistance to HRSV neutralizing antibodies directed against the F protein and the fusion activity of the F protein, a…”
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Clinical Features, Adenovirus Types, and Local Production of Inflammatory Mediators in Adenovirus Infections by Moro, Maria R, Bonville, Cynthia A, Suryadevara, Manika, Cummings, Erin, Faddoul, Diala, Kobayaa, Hazar, Branigan, Patrick J, Domachowske, Joseph B

“…BACKGROUND:Adenovirus infection manifests in many ways, with respiratory and gastrointestinal symptoms predominating. METHODS:We performed a retrospective…”
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Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease by Del Vecchio, Alfred M, Branigan, Patrick J, Barnathan, Elliot S, Flavin, Susan K, Silkoff, Philip E, Turner, Ronald B

“…Abstract There is an association with acute viral infection of the respiratory tract and exacerbations of asthma and chronic obstructive pulmonary disease…”
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Interferon gamma enhances clonal expansion and survival of CD4+ T cells by Reed, Jennifer M, Branigan, Patrick J, Bamezai, Anil

“…Interferon-gamma (IFN-gamma) serves numerous functions in the regulation of the immune response. During the early phase of the immune response IFN-gamma is…”
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Characterization of the epitope for anti-human respiratory syncytial virus F protein monoclonal antibody 101F using synthetic peptides and genetic approaches by Wu, Sheng-Jiun, Schmidt, Albert, Beil, Eric J, Day, Nicole D, Branigan, Patrick J, Liu, Changbao, Gutshall, Lester L, Palomo, Concepcion, Furze, Julie, Taylor, Geraldine, Melero, Jose A, Tsui, Ping, Del Vecchio, Alfred M, Kruszynski, Marian

“…1 Protein Engineering, Centocor R&D Inc., 145 King of Prussia Road, Radnor, PA 19087, USA 2 Immunobiology, Centocor R&D Inc., 145 King of Prussia Road, Radnor,…”
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Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain by BALIN, B. J, GERARD, H. C, ARKING, E. J, APPELT, D. M, BRANIGAN, P. J, ABRAMS, J. T, WHITTUM-HUDSON, J. A, HUDSON, A. P

“…We assessed whether the intracellular bacterium Chlamydia pneumoniae was present in post-mortem brain samples from patients with and without late-onset…”
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A MUC1/IL-18 DNA vaccine induces anti-tumor immunity and increased survival in MUC1 transgenic mice by Snyder, Linda A., Goletz, Theresa J., Gunn, George R., Shi, Frank F., Harris, Michael C., Cochlin, Karyn, McCauley, Christine, McCarthy, Stephen G., Branigan, Patrick J., Knight, David M.

“…MUC1 (mucin 1) is a tumor-associated antigen that is overexpressed in many adenocarcinomas. Active immunotherapy targeting tumors expressing MUC1 could have…”
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Diminished inflammatory responses to natural pneumovirus infection among older mice by Bonville, Cynthia A, Bennett, Nicholas J, Percopo, Caroline M, Branigan, Patrick J, Del Vecchio, Alfred M, Rosenberg, Helene F, Domachowske, Joseph B

“…Abstract Immune responses to virus infection undergo significant change as part of the aging process. Here we examine the inflammatory responses of older, but…”
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The cytoplasmic domain of the F protein of Human respiratory syncytial virus is not required for cell fusion by Branigan, Patrick J, Day, Nicole D, Liu, Changbao, Gutshall, Lester L, Melero, Jose A, Sarisky, Robert T, Vecchio, Alfred M. Del

“…1 Department of Infectious Diseases Research, Centocor Inc., 145 King of Prussia Road, Radnor, PA 19087, USA 2 Centro Nacional de Microbiología, Instituto de…”
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Chemokine expression during mouse hepatitis virus-induced encephalitis: Contributions of the spike and background genes by Scott, Erin P, Branigan, Patrick J, Del Vecchio, Alfred M, Weiss, Susan R

“…Infection of mice with mouse hepatitis virus (MHV) strain JHM (RJHM) induces lethal encephalitis, with high macrophage and neutrophil, but minimal T-cell,…”
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Generation of a protective T-cell response following coronavirus infection of the central nervous system is not dependent on IL-12/23 signaling by Held, Katherine S, Glass, William G, Orlovsky, Yevgeniya I, Shamberger, Kimberly A, Petley, Ted D, Branigan, Patrick J, Carton, Jill M, Beck, Heena S, Cunningham, Mark R, Benson, Jacqueline M, Lane, Thomas E

“…The functional role of IL-12 and IL-23 in host defense and disease following viral infection of the CNS was determined. Instillation of mouse hepatitis virus…”
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Viability of Chlamydia trachomatis in fallopian tubes of patients with ectopic pregnancy by Gérard, H C, Branigan, P J, Balsara, G R, Heath, C, Minassian, S S, Hudson, A P

“…To use standard molecular methods to define the prevalence and metabolic characteristics of Chlamydia trachomatis during infection of fallopian tubes in women…”
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