Search Results - "Patrick G Holt"

Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatment by Holt, Patrick G, Sly, Peter D

“…Viral infections can worsen episodes of allergic sensitization to allergens, putting the affected individuals, often children, at risk for developing…”
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The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development by Teo, Shu Mei, Mok, Danny, Pham, Kym, Kusel, Merci, Serralha, Michael, Troy, Niamh, Holt, Barbara J., Hales, Belinda J., Walker, Michael L., Hollams, Elysia, Bochkov, Yury A., Grindle, Kristine, Johnston, Sebastian L., Gern, James E., Sly, Peter D., Holt, Patrick G., Holt, Kathryn E., Inouye, Michael

“…The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting from ARIs during infancy is…”
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Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages by Tarique, Abdullah A, Logan, Jayden, Thomas, Emma, Holt, Patrick G, Sly, Peter D, Fantino, Emmanuelle

“…Macrophages are dynamic cells that mature under the influence of signals from the local microenvironment into either classically (M1) or alternatively (M2)…”
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The mechanism or mechanisms driving atopic asthma initiation: The infant respiratory microbiome moves to center stage by Holt, Patrick G., DSc, FRCPath, FRCPI, FAA

“…Developments over the last 5 to 10 years, principally from studies on comprehensively phenotyped prospective birth cohorts, have highlighted the important role…”
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Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease by Teo, Shu Mei, Tang, Howard H.F., Mok, Danny, Judd, Louise M., Watts, Stephen C., Pham, Kym, Holt, Barbara J., Kusel, Merci, Serralha, Michael, Troy, Niamh, Bochkov, Yury A., Grindle, Kristine, Lemanske, Robert F., Johnston, Sebastian L., Gern, James E., Sly, Peter D., Holt, Patrick G., Holt, Kathryn E., Inouye, Michael

“…Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in children. In this study, the…”
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Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma by Kusel, Merci M.H., MBBS, PhD, de Klerk, Nicholas H., MSc, PhD, Kebadze, Tatiana, MD, Vohma, Vaike, BSc(Hons), Holt, Patrick G., DSc, Johnston, Sebastian L., MD, PhD, FRCP, Sly, Peter D., MD, FRACP, DSc

“…Background Severe lower respiratory infections (LRIs) and atopic sensitization have been identified as independent risk factors for asthma. Objective The…”
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Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents by HOLLAMS, Elysia M, DE KLERK, Nicholas H, HOLT, Patrick G, SLY, Peter D

“…The extent to which maternal smoking in pregnancy (MSP) has persisting effects on respiratory health remains uncertain and the mechanisms involved are not…”
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Vitamin D over the first decade and susceptibility to childhood allergy and asthma by Hollams, Elysia M., PhD, Teo, Shu Mei, PhD, Kusel, Merci, MBBS, PhD, Holt, Barbara J., BSc, Holt, Kathryn E., PhD, Inouye, Michael, PhD, De Klerk, Nicholas H., PhD, Zhang, Guicheng, PhD, Sly, Peter D., FRACP, Hart, Prue H., PhD, Holt, Patrick G., DSc

“…Background Vitamin D (25(OH)D) deficiency has been implicated as a possible risk factor for asthma development, but studies at selected time points measuring…”
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Prenatal adverse life events increase the risk for atopic diseases in children, which is enhanced in the absence of a maternal atopic predisposition by Hartwig, Isabel R.V., MSc, Sly, Peter D., MD, Schmidt, Louis A., PhD, van Lieshout, Ryan J., MD, PhD, Bienenstock, John, MD, Holt, Patrick G., PhD, Arck, Petra C., MD

“…Background There is evidence to suggest an association between prenatal maternal stress and the development of asthma or other atopic diseases in offspring…”
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Maternal Serum Vitamin D Levels During Pregnancy and Offspring Neurocognitive Development by WHITEHOUSE, Andrew J. O, HOLT, Barbara J, SERRALHA, Michael, HOLT, Patrick G, KUSEL, Merci M. H, HART, Prue H

“…To determine the association between maternal serum 25(OH)-vitamin D concentrations during a critical window of fetal neurodevelopment and behavioral,…”
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Prophylactic use of sublingual allergen immunotherapy in high-risk children: A pilot study by Holt, Patrick G., FAA, Sly, Peter D., FRACP, Sampson, Hugh A., MD, Robinson, Phil, PhD, Loh, Richard, FRACP, Lowenstein, Henning, PhD, Calatroni, Agustin, MS, Sayre, Peter, MD

“…The basis for one emerging therapeutic strategy is the consistent finding in experimental models that development of resistance to inhalant allergy is actively…”
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Regulation of immunological homeostasis in the respiratory tract by Holt, Patrick G, Strickland, Deborah H, Wikström, Matthew E, Jahnsen, Frode L

“…Key Points The central theme of this Review is how the respiratory immune system maintains a strong defence against incoming pathogens, while avoiding the…”
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Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis by Jones, Anya C, Anderson, Denise, Galbraith, Sally, Fantino, Emmanuelle, Gutierrez Cardenas, Diana, Read, James F, Serralha, Michael, Holt, Barbara J, Strickland, Deborah H, Sly, Peter D, Bosco, Anthony, Holt, Patrick G

“…A subset of infants are hypersusceptible to severe/acute viral bronchiolitis (AVB), for reasons incompletely understood. To characterize the cellular/molecular…”
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Rapid recruitment of CD14+ monocytes in experimentally induced allergic rhinitis in human subjects by Eguíluz-Gracia, Ibon, MD, Bosco, Anthony, PhD, Dollner, Ralph, MD, PhD, Melum, Guro Reinholt, MD, PhD, Lexberg, Maria H., PhD, Jones, Anya C., PhD, Dheyauldeen, Sinan Ahmed, MD, Holt, Patrick G., PhD, Bækkevold, Espen S., PhD, Jahnsen, Frode Lars, MD, PhD

“…Background Activated TH 2 cells and eosinophils are hallmarks of the allergic inflammation seen in patients with allergic rhinitis (AR). However, which cells…”
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Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk by Huang, Qin Qin, Tang, Howard H. F., Teo, Shu Mei, Mok, Danny, Ritchie, Scott C., Nath, Artika P., Brozynska, Marta, Salim, Agus, Bakshi, Andrew, Holt, Barbara J., Khor, Chiea Chuen, Sly, Peter D., Holt, Patrick G., Holt, Kathryn E., Inouye, Michael

“…Chronic immune-mediated diseases of adulthood often originate in early childhood. To investigate genetic associations between neonatal immunity and disease, we…”
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Do early-life viral infections cause asthma? by Sly, Peter D., MD, FRACP, DSc, Kusel, Merci, MBBS, Holt, Patrick G., DSc

“…Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known. However, the question of whether…”
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Immunogenicity, reactogenicity, and IgE-mediated immune responses of a mixed whole-cell and acellular pertussis vaccine schedule in Australian infants: A randomised, double-blind, noninferiority trial by Pérez Chacón, Gladymar, Estcourt, Marie J, Totterdell, James, Marsh, Julie A, Perrett, Kirsten P, Campbell, Dianne E, Wood, Nicholas, Gold, Michael, Waddington, Claire S, O' Sullivan, Michael, McAlister, Sonia, Curtis, Nigel, Jones, Mark, McIntyre, Peter B, Holt, Patrick G, Richmond, Peter C, Snelling, Tom

“…In many countries, infant vaccination with acellular pertussis (aP) vaccines has replaced use of more reactogenic whole-cell pertussis (wP) vaccines. Based on…”
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LPS binding protein and activation signatures are upregulated during asthma exacerbations in children by Jones, Anya C, Leffler, Jonatan, Laing, Ingrid A, Bizzintino, Joelene, Khoo, Siew-Kim, LeSouef, Peter N, Sly, Peter D, Holt, Patrick G, Strickland, Deborah H, Bosco, Anthony

“…Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune…”
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Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years by Read, James F., Serralha, Michael, Armitage, Jesse D., Iqbal, Muhammad Munir, Cruickshank, Mark N., Saxena, Alka, Strickland, Deborah H., Waithman, Jason, Holt, Patrick G., Bosco, Anthony

“…BackgroundHuman perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure…”
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Interactions between innate and adaptive immunity in asthma pathogenesis: New perspectives from studies on acute exacerbations by Holt, Patrick G., DSc, FAA, Strickland, Deborah H., PhD

“…Asthma is a complex multigenic disease. The most frequently encountered form is atopic asthma, which is at its highest prevalence during childhood/young…”
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