Search Results - "Patrick, Kennerly S."

An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study by Zhu, Hao-Jie, Brinda, Bryan J, Chavin, Kenneth D, Bernstein, Hilary J, Patrick, Kennerly S, Markowitz, John S

“…Milk thistle (Silybum marianum) extracts, one of the most widely used dietary supplements, contain a mixture of six major flavonolignans (silybin A, silybin B,…”
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Two CES1 Gene Mutations Lead to Dysfunctional Carboxylesterase 1 Activity in Man: Clinical Significance and Molecular Basis by Zhu, Hao-Jie, Patrick, Kennerly S., Yuan, Hong-Jie, Wang, Jun-Sheng, Donovan, Jennifer L., DeVane, C. Lindsay, Malcolm, Robert, Johnson, Julie A., Youngblood, Geri L., Sweet, Douglas H., Langaee, Taimour Y., Markowitz, John S.

“…The human carboxylesterase 1 ( CES1) gene encodes for the enzyme carboxylesterase 1, a serine esterase governing both metabolic deactivation and activation of…”
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Enantiospecific determination of dl-methylphenidate and dl-ethylphenidate in plasma by liquid chromatography–tandem mass spectrometry: Application to human ethanol interactions by Zhu, Hao-Jie, Patrick, Kennerly S., Markowitz, John S.

“…In humans, concomitant dl-methylphenidate ( dl-MPH) and ethanol results in the carboxylesterase 1 (hCES1) mediated biotransformation of MPH to the…”
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Advances in the Pharmacotherapy of Attention-Deficit-Hyperactivity Disorder: Focus on Methylphenidate Formulations by Markowitz, John S., Straughn, Arthur B., Patrick, Kennerly S.

“…The psychostimulant dl‐methylphenidate (MPH) remains the most common drug therapy in child and adolescent psychiatry for the treatment of…”
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Long-Term Consequences of Methamphetamine Exposure in Young Adults Are Exacerbated in Glial Cell Line-Derived Neurotrophic Factor Heterozygous Mice by Boger, Heather A, Middaugh, Lawrence D, Patrick, Kennerly S, Ramamoorthy, Sammanda, Denehy, Emily D, Zhu, Haojie, Pacchioni, Alejandra M, Granholm, Ann-Charlotte, McGinty, Jacqueline F

“…Methamphetamine abuse in young adults has long-term deleterious effects on brain function that are associated with damage to monoaminergic neurons…”
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Potential for Underestimation of d-Methylphenidate Bioavailability Using Chiral Derivatization/Gas Chromatography by Patrick, Kennerly S, Rodriguez, Wendy

“…A tenable hypothesis is presented which explains disparities between older oral dl-MPH bioavailability data generated using chiral derivatization-gas…”
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The Clinical Pharmacokinetics of Amphetamines Utilized in the Treatment of Attention-Deficit/Hyperactivity Disorder by Markowitz, John S, Patrick, Kennerly S

“…Amphetamine (AMP), an indirectly acting psychostimulant approved for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents,…”
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A novel HPLC fluorescence method for the quantification of methylphenidate in human plasma by Zhu, Hao-Jie, Wang, Jun-Sheng, Patrick, Kennerly S., Donovan, Jennifer L., DeVane, C. Lindsay, Markowitz, John S.

“…A number of analytical methods have been established to quantify methylphenidate (MPH). However, to date no HPLC methods are applicable to human…”
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Plasma Carboxylesterase 1 Predicts Methylphenidate Exposure: A Proof‐of‐Concept Study Using Plasma Protein Biomarker for Hepatic Drug Metabolism by Shi, Jian, Xiao, Jingcheng, Wang, Xinwen, Jung, Sun Min, Bleske, Barry E., Markowitz, John S., Patrick, Kennerly S., Zhu, Hao‐Jie

“…Hepatic drug‐metabolizing enzymes (DMEs) play critical roles in determining the pharmacokinetics and pharmacodynamics of numerous therapeutic agents. As such,…”
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New methylphenidate formulations for the treatment of attention-deficit/hyperactivity disorder by Patrick, Kennerly S, González, Mario A, Straughn, Arthur B, Markowitz, John S

“…dl-Methylphenidate (MPH) remains the most widely used pharmacological agent in the treatment of attention-deficit/hyperactivity disorder (ADHD). The…”
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Enantiospecific gas chromatographic–mass spectrometric analysis of urinary methylphenidate: Implications for phenotyping by LeVasseur, Natalie L., Zhu, Hao-Jie, Markowitz, John S., DeVane, C. Lindsay, Patrick, Kennerly S.

“…A chiral derivatization gas chromatographic–mass spectrometric (GC–MS) method for urine methylphenidate (MPH) analysis was developed and validated to…”
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Ethylphenidate as a selective dopaminergic agonist and methylphenidate-ethanol transesterification biomarker by Patrick, Kennerly S, Corbin, Timothy R, Murphy, Cristina E

“…We review the pharmaceutical science of ethylphenidate (EPH) in the contexts of drug discovery, drug interactions, biomarker for dl-methylphenidate…”
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Absorption Differences between Immediate-Release Dexmethylphenidate and dl-Methylphenidate by Patrick, Kennerly S, Straughn, Arthur B

“…The postulate that twice the milligram/kilogram dose of dl-methylphenidate (dl-MPH) would result in equal exposure to d-MPH compared with half that…”
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Differential pharmacokinetics and pharmacodynamics of methylphenidate enantiomers: does chirality matter? by Markowitz, John S, Patrick, Kennerly S

“…d,l-threo-methylphenidate (MPH) is an effective first-line treatment for the symptoms associated with attention-deficit/hyperactivity disorder…”
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THE ROLE OF THE POLYMORPHIC EFFLUX TRANSPORTER P-GLYCOPROTEIN ON THE BRAIN ACCUMULATION OF d-METHYLPHENIDATE AND d-AMPHETAMINE by ZHU, Hao-Jie, WANG, Jun-Sheng, LINDSAY DEVANE, C, WILLIARD, Robin L, DONOVAN, Jennifer L, MIDDAUGH, Lawrence D, GIBSON, Brian B, PATRICK, Kennerly S, MARKOWITZ, John S

“…The psychostimulant medications methylphenidate (MPH) and amphetamine (AMP), available in various ratios or enantiopure formulations of their respective active…”
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Ethanol Interactions With Dexmethylphenidate and dl-Methylphenidate Spheroidal Oral Drug Absorption Systems in Healthy Volunteers by Zhu, Hao-Jie, Patrick, Kennerly S, Straughn, Arthur B, Reeves, 3rd, Owen T, Bernstein, Hilary, Shi, Jian, Johnson, Heather J, Knight, Joshua M, Smith, Aaron T, Malcolm, Robert J, Markowitz, John S

“…Ethanol coadministered with immediate-release dl-methylphenidate (dl-MPH) or dexmethylphenidate (d-MPH) significantly increases the geomean maximum plasma…”
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Inducible Nitric Oxide Synthase Inhibitors Reduce Urinary Markers of Systemic Oxidant Stress in Murine Proliferative Lupus Nephritis by Njoku, Chinedu J., Patrick, Kennerly S., Ruiz, Philip, Oates, Jim C.

“…BackgroundProliferative lupus nephritis (PLN) is characterized by increased expression of inducible nitric oxide (NO) synthase (iNOS). Inhibition of iNOS with…”
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Comparative Ethanol-Induced Potentiation of Stimulatory Responses to Dexmethylphenidate Versus Methylphenidate by Patrick, Kennerly S, Straughn, Arthur B, Reeves, 3rd, Owen T, Bernstein, Hilary, Malcolm, Robert

“…The potentiation of positive subjective responses to immediate-release dexmethylphenidate (d-MPH) or dl-methylphenidate (dl-MPH) by ethanol was investigated…”
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Isopropylphenidate: an ester homolog of methylphenidate with sustained and selective dopaminergic activity and reduced drug interaction liability by Markowitz, John S, Zhu, Hao-Jie, Patrick, Kennerly S

“…The most widely utilized pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD) is the psychostimulant methylphenidate (MPH). Most MPH…”
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Differential influences of ethanol on early exposure to racemic methylphenidate compared with dexmethylphenidate in humans by Patrick, Kennerly S, Straughn, Arthur B, Reeves, 3rd, Owen T, Bernstein, Hilary, Bell, Guinevere H, Anderson, Erica R, Malcolm, Robert J

“…Enantioselective hydrolysis of oral racemic methylphenidate (dl-MPH) by carboxylesterase 1 (CES1) limits the absolute bioavailability of the pharmacologically…”
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