Search Results - "Patrick, Aaron"

High Throughput Phenotyping of Blueberry Bush Morphological Traits Using Unmanned Aerial Systems by Patrick, Aaron, Li, Changying

“…Phenotyping morphological traits of blueberry bushes in the field is important for selecting genotypes that are easily harvested by mechanical harvesters…”
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Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome by Patrick, Aaron N, Cabrera, Joshua H, Smith, Anna L, Chen, Xiaojiang S, Ford, Heide L, Zhao, Rui

“…SIX1–EYA form a bipartite transcription factor, essential for development, whose overexpression is linked to metastasis. The crystal structure of SIX1 bound to…”
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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction by Blevitt, Jonathan M, Hack, Michael D, Herman, Krystal L, Jackson, Paul F, Krawczuk, Paul J, Lebsack, Alec D, Liu, Annie X, Mirzadegan, Taraneh, Nelen, Marina I, Patrick, Aaron N, Steinbacher, Stefan, Milla, Marcos E, Lumb, Kevin J

“…A prevalent observation in high-throughput screening and drug discovery programs is the inhibition of protein function by small-molecule compound aggregation…”
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The SIX1-EYA transcriptional complex as a therapeutic target in cancer by Blevins, Melanie A, Towers, Christina G, Patrick, Aaron N, Zhao, Rui, Ford, Heide L

“…The SIX homeodomain proteins and the eyes absent (EYA) family of co-activators form a bipartite transcription factor complex that promotes the proliferation…”
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SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer by Wang, Chu-An, Jedlicka, Paul, Patrick, Aaron N, Micalizzi, Douglas S, Lemmer, Kimberly C, Deitsch, Erin, Casás-Selves, Matias, Harrell, J Chuck, Ford, Heide L

“…An association between lymph node metastasis and poor prognosis in breast cancer was observed decades ago. However, the mechanisms by which tumor cells…”
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JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans by Fourie, Anne M., Cheng, Xiaoli, Chang, Leon, Greving, Carrie, Li, Xinyi, Knight, Beverly, Polidori, David, Patrick, Aaron, Bains, Trpta, Steele, Ruth, Allen, Samantha J., Patch, Raymond J., Sun, Chengzao, Somani, Sandeep, Bhandari, Ashok, Liu, David, Huie, Keith, Li, Shu, Rodriguez, Michael A., Xue, Xiaohua, Kannan, Arun, Kosoglou, Teddy, Sherlock, Jonathan P., Towne, Jennifer, Holland, M. Claire, Modi, Nishit B.

“…The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics…”
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CDK6 binds and promotes the degradation of the EYA2 protein by Kohrt, Dawn, Crary, Jennifer, Zimmer, Marc, Patrick, Aaron, Ford, Heide, Hinds, Philip W., Grossel, Martha J.

“…Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G 1 phase…”
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Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration by Krueger, Aaron B., Drasin, David J., Lea, Wendy A., Patrick, Aaron N., Patnaik, Samarjit, Backos, Donald S., Matheson, Christopher J., Hu, Xin, Barnaeva, Elena, Holliday, Michael J., Blevins, Melanie A., Robin, Tyler P., Eisenmesser, Elan Z., Ferrer, Marc, Simeonov, Anton, Southall, Noel, Reigan, Philip, Marugan, Juan, Ford, Heide L., Zhao, Rui

“…Eya proteins are essential co-activators of the Six family of transcription factors and contain a unique tyrosine phosphatase domain belonging to the haloacid…”
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Biochemical and Functional Characterization of Six SIX1 Branchio-oto-renal Syndrome Mutations by Patrick, Aaron N., Schiemann, Barbara J., Yang, Kui, Zhao, Rui, Ford, Heide L.

“…Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder characterized by hearing loss, branchial arch defects, and renal anomalies…”
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Probing the CRL4DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons by Righetto, Germanna Lima, Yin, Yanting, Duda, David M, Vu, Victoria, Szewczyk, Magdalena M, Zeng, Hong, Li, Yanjun, Loppnau, Peter, Mei, Tony, Li, Yen-Yen, Seitova, Alma, Patrick, Aaron N, Brazeau, Jean-Francois, Chaudhry, Charu, Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Halabelian, Levon

“…Abstract Damaged DNA-binding protein-1 (DDB1)- and CUL4-associated factor 12 (DCAF12) serves as the substrate recognition component within the Cullin4–RING E3…”
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Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor by Yu, Xiaodi, Abeywickrema, Pravien, Bonneux, Brecht, Behera, Ishani, Anson, Brandon, Jacoby, Edgar, Fung, Amy, Adhikary, Suraj, Bhaumik, Anusarka, Carbajo, Rodrigo J., De Bruyn, Suzanne, Miller, Robyn, Patrick, Aaron, Pham, Quyen, Piassek, Madison, Verheyen, Nick, Shareef, Afzaal, Sutto-Ortiz, Priscila, Ysebaert, Nina, Van Vlijmen, Herman, Jonckers, Tim H. M., Herschke, Florence, McLellan, Jason S., Decroly, Etienne, Fearns, Rachel, Grosse, Sandrine, Roymans, Dirk, Sharma, Sujata, Rigaux, Peter, Jin, Zhinan

“…The respiratory syncytial virus polymerase complex, consisting of the polymerase (L) and phosphoprotein (P), catalyzes nucleotide polymerization, cap addition,…”
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Identification of Two Non-Peptidergic Small Molecule Inhibitors of CBX2 Binding to K27 Trimethylated Oligonucleosomes by Lercher, Lukas, Simon, Nina, Bergmann, Andreas, Tauchert, Marcel, Bochmann, David, Bashir, Tarig, Neuefeind, Torsten, Riley, Daniel, Danna, Ben, Krawczuk, Paul, Pande, Vineet, Patrick, Aaron, Steele, Ruth, Wang, Weixue, Rupnow, Brent, Tummino, Peter, Sharma, Sujata, Finley, Michael

“…The dysregulation of the PRC1/2 complex plays a key role in lineage plasticity in prostate cancer and may be required to maintain neuroendocrine phenotype. [1]…”
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Specificity and prognostic validation of a polyclonal antibody to detect Six1 homeoprotein in ovarian cancer by Qamar, Lubna, Deitsch, Erin, Patrick, Aaron N, Post, Miriam D, Spillman, Monique A, Iwanaga, Ritsuko, Thorburn, Andrew, Ford, Heide L, Behbakht, Kian

“…Abstract Objective The presence of Six1 mRNA gene portends a poor prognosis in ovarian cancer. We describe validation of a Six1 specific antibody and evaluate…”
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The Six Family of Homeobox Genes in Development and Cancer by Christensen, Kimberly L, Patrick, Aaron N, McCoy, Erica L, Ford, Heide L

“…The homeobox gene superfamily encodes transcription factors that act as master regulators of development through their ability to activate or repress a diverse…”
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Community Transmission of SARS-CoV-2 Associated with a Local Bar Opening Event - Illinois, February 2021 by Sami, Samira, Turbyfill, Caitlin R, Daniel-Wayman, Shelby, Shonkwiler, Stacy, Fisher, Kiva A, Kuhring, Macey, Patrick, Aaron M, Hinton, Stephanie, Minor, Amanda S, Ricaldi, Jessica N, Ezike, Ngozi, Kauerauf, Judy, Duffus, Wayne A

“…During February 2021, an opening event was held indoors at a rural Illinois bar that accommodates approximately 100 persons. The Illinois Department of Public…”
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Hand Pain In A Wrestler: 1295 by Tracy, Aaron Patrick

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Hand Pain In A Wrestler: 1295 by Tracy, Aaron Patrick

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The genome of ε15, a serotype-converting, Group E1 Salmonella enterica -specific bacteriophage by Kropinski, Andrew M, Kovalyova, Irina V, Billington, Stephen J, Patrick, Aaron N, Butts, Brent D, Guichard, Jared A, Pitcher, Trevor J, Guthrie, Carly C, Sydlaske, Anya D, Barnhill, Lisa M, Havens, Kyle A, Day, Kenneth R, Falk, Darrel R, McConnell, Michael R

“…Abstract The genome sequence of the Salmonella enterica serovar Anatum-specific, serotype-converting bacteriophage ε15 has been completed. The nonredundant…”
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The Roles of the Residues on the Channel β-Hairpin and Loop Structures of Simian Virus 40 Hexameric Helicase by Shen, Jingping, Gai, Dahai, Patrick, Aaron, Greenleaf, William B., Chen, Xiaojiang S., Hurwitz, Jerard

“…Simian virus 40 large tumor antigen is required for DNA unwinding during viral replication. The helicase-active form of large tumor antigen is a ring-shaped…”
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Chapter 5 The Six Family of Homeobox Genes in Development and Cancer by Christensen, Kimberly L., Patrick, Aaron N., McCoy, Erica L., Ford, Heide L.

“…The homeobox gene superfamily encodes transcription factors that act as master regulators of development through their ability to activate or repress a diverse…”
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