Search Results - "Patrene, K"
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Bone Marrow as a Potential Source of Hepatic Oval Cells
Published in Science (American Association for the Advancement of Science) (14-05-1999)“…Bone marrow stem cells develop into hematopoietic and mesenchymal lineages but have not been known to participate in production of hepatocytes, biliary cells,…”
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Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
Published in Leukemia (01-08-2013)“…Hypoxia-inducible transcription factor-1 (HIF-1α) is overexpressed in multiple myeloma (MM) cells within the hypoxic microenvironment. Herein, we explored the…”
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A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers
Published in The Journal of immunology (1950) (01-11-1995)“…Reconstitution of lethally irradiated mice with a mixture of syngeneic and allogeneic (A+B-->A) bone marrow results in multilineage mixed allogeneic chimerism,…”
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Efficient Transfer and Sustained High Expression of the Human Glucocerebrosidase Gene in Mice and their Functional Macrophages Following Transplantation of Bone Marrow Transduced by a Retroviral Vector
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-1992)“…A recombinant retroviral vector (MFG-GC) was used to study the efficiency of transduction of the human gene encoding glucocerebrosidase (GC;…”
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Constitutive systemic expression of IL-1Ra or soluble TNF receptor by genetically modified hematopoietic cells suppresses LPS induction of IL-6 and IL-10
Published in Gene therapy (01-03-1997)“…We have been developing both local and systemic gene therapy approaches to treat inflammatory and autoimmune diseases. To determine if systemic, constitutive…”
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Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach
Published in The Journal of immunology (1950) (01-10-1996)“…For over 40 years, the association between hemopoietic chimerism and donor-specific tolerance for allografts has been recognized. However, toxicity associated…”
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Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice
Published in The Journal of immunology (1950) (01-01-1996)“…Evidence in experimental models suggests that many autoimmune diseases can be prevented by transplantation of bone marrow from disease-resistant donors. For…”
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Role of CD44 in the development of natural killer cells from precursors in long-term cultures of mouse bone marrow
Published in The Journal of immunology (1950) (01-06-1994)“…The role of the adhesion molecule CD44 in the development of NK cells was analyzed in a mouse long-term bone marrow culture system. After 4 wk of culture (day…”
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Retroviral gene transfer and sustained expression of human arylsulfatase A
Published in Gene therapy (01-04-1996)“…Transduction of mouse hematopoietic stem cells and their progeny was studied using a recombinant retroviral vector (MFG-ASA) which incorporates the human…”
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Short-term myeloid reconstitution following TBI is not adversely affected by doses of FK506 that abrogate lethal GVHD
Published in Bone marrow transplantation (Basingstoke) (01-09-1994)“…Studies were undertaken to determine whether the doses of FK506 that are effective for acute GVHD prophylaxis following lethal irradiation and bone marrow…”
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Hematopoiesis and aging III: Anemia and a blunted erythropoietic response to hemorrhage in aged mice
Published in American journal of hematology (01-08-1985)“…Whether the hematocrit normally declines in the aged or whether such a decline represents inapparent disease in addition to aging is a matter of dispute…”
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Purified murine hematopoietic stem cells function longer on nonirradiated W41/Wv than on +/+ irradiated stroma
Published in Blood (15-03-1993)“…Mouse bone marrow (BM) was separated into low-density, lineage-negative, wheat germ agglutinin-positive (WGA+), Rhodamine-123 bright (Rhbright) or dim (Rhdim)…”
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16,16-Dimethyl prostaglandin E2 and/or syngeneic bone marrow transplantation increase mouse survival after supra-lethal total body irradiation
Published in International journal of radiation oncology, biology, physics (01-06-1990)“…We evaluated the effects of 16,16-dimethyl prostaglandin E2 (dm-PGE2), with and without syngeneic bone marrow transplantation (BMT) on the survival and…”
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Hypoxia-inducible factor (HIF)-1[alpha] suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction
Published in Leukemia (01-08-2013)“…Hypoxia-inducible transcription factor-1 (HIF-1α) is overexpressed in multiple myeloma (MM) cells within the hypoxic microenvironment. Herein, we explored the…”
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ADAM8 enhances osteoclast precursor fusion and osteoclast formation in vitro and in vivo
Published in Journal of bone and mineral research (01-01-2011)“…ADAM8 expression is increased in the interface tissue around a loosened hip prosthesis and in the pannus and synovium of patients with rheumatoid arthritis,…”
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The effect of DFMO induced uptake of [3H] putrescine on human glioma cells
Published in Journal of neuro-oncology (01-11-2001)“…Polyamine synthesis inhibitors, such as a-difluoromethylornithine (DFMO), inhibit tumor cell growth in vitro and in vivo. However, upon cessation of treatment,…”
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Generation of natural killer cells from long-term cultures of mouse bone marrow
Published in Natural immunity (01-01-1993)“…The features of a mouse long-term bone marrow culture (LTBMC) system that produces natural killer (NK) cell activity are described. Over a 4-week period in the…”
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Aging and hematopoiesis. VI. Neutrophilia and other leukocyte changes in aged mice
Published in Experimental hematology (01-06-1986)“…The concentration of blood leukocytes rose progressively as mice aged. All blood leukocytes increased, although a greater degree of increase was seen in…”
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Characterization of the stage in natural killer cell development in 14.5-day mouse fetal liver using adult bone marrow stroma
Published in Experimental hematology (01-06-1999)“…Nonstimulated fetal liver (FL) from 14.5-day gestation mice had no natural killer (NK) cell activity and <3% expressed NK1.1. Even after short-term (3–4 day)…”
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