Search Results - "Paton, R D"

The Development of Delivery Agents that Facilitate the Oral Absorption of Macromolecular Drugs by Leone-Bay, Andrea, Paton, Duncan R., Weidner, John J.

“…Macromolecules comprise a growing group of new drugs with great clinical promise. To date, the therapeutic application of these drugs has been limited, because…”
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Acylated non-α-amino acids as novel agents for the oral delivery of heparin sodium, USP by Leone-Bay, Andrea, Paton, Duncan R, Variano, Bruce, Leipold, Harry, Rivera, Theresa, Miura-Fraboni, Judy, Baughman, Robert A, Santiago, Noemi

“…Ten N-acylated, non-α-amino acids have been prepared as oral delivery agents and used to demonstrate the oral delivery of heparin in vivo in rats and primates…”
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Oral delivery of heparin in combination with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate : Pharmacological considerations by RIVERA, T. M, LEONE-BAY, A, PATON, D. R, LEIPOLD, H. R, BAUGHMAN, R. A

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Synthesis and Evaluation of Compounds That Facilitate the Gastrointestinal Absorption of Heparin by Leone-Bay, Andrea, Paton, Duncan R, Freeman, John, Lercara, Christine, O'Toole, Doris, Gschneidner, David, Wang, Eric, Harris, Elizabeth, Rosado, Connie, Rivera, Theresa, DeVincent, Aldonna, Tai, Monica, Mercogliano, Frank, Agarwal, Rajesh, Leipold, Harry, Baughman, Robert A

“…A family of novel compounds (delivery agents) that promote the gastrointestinal absorption of USP heparin in rats and primates has been discovered. The…”
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Acute-phase responses to cardiopulmonary bypass in children weighing less than 10 kilograms by Butler, John, Pathi, Vivek L., Paton, Robert D., Logan, Robert W., MacArthur, Kenneth J.D., Jamieson, Morgan P.G., Pollock, James C.S.

“…Cardiopulmonary bypass induces a systemic inflammatory response. This study investigated, in a pediatric population, cytokine-induced responses and their…”
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Thermodynamic characterization of an intermediate state of human growth hormone by Gomez‐Orellana, Isbuel, Varinano, Bruce, Miura‐Fraboni, Judy, Milstein, Sam, Paton, Duncan R.

“…The thermal denaturation of recombinant human growth hormone (rhGH) was studied by differential scanning calorimetry and circular dichroism spectroscopy (CD)…”
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Salicylate toxicity masquerading as malignant hyperthermia by CANDY, J. M, MORRISON, C, PATON, R. D, LOGAN, R. W, LAWSON, R

“…We report a case of hyperpyrexia presumed due to topical salicylate toxicity occurring immediately following general anaesthesia for appendicectomy in an…”
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The effects of cardiopulmonary bypass on thyroid function in infants weighing less than five kilograms by Mitchell, I M, Pollock, J C, Jamieson, M P, Donaghey, S F, Paton, R D, Logan, R W

“…Triiodothyronine is an important regulator of cellular metabolism and may have potential use as an inotropic agent. The aim of this study was to determine the…”
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Endothelin-1 levels in infants with pulmonary hypertension receiving extracorporeal membrane oxygenation by Macdonald, P D, Paton, R D, Logan, R W, Skeoch, C H, Davis, C F

“…We studied the possibility of an etiological role for endothelin-1 (ET-1) in the development of persistent pulmonary hypertension of the newborn (PPHN). Ten…”
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Hypomagnesaemic tetany by Ramage, I J, Ray, M, Paton, R D, Logan, R W, Beattie, T J

“…Hypomagnesaemic tetany (hypomagnesaemic tetany with secondary hypocalcaemia) is a rare inherited form of hypomagnesaemia. Initial reports involved affected…”
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4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric Acid as a Novel Oral Delivery Agent for Recombinant Human Growth Hormone by Leone-Bay, Andrea, Ho, Koc-Kan, Agarwal, Rajesh, Baughman, Robert A, Chaudhary, Kiran, DeMorin, Frenel, Genoble, Lise, McInnes, Campbell, Lercara, Christine, Milstein, Sam, O'Toole, Doris, Sarubbi, Donald, Variano, Bruce, Paton, Duncan R

“…A series of N-acetylated, non-α, aromatic amino acids was prepared and shown to promote the absorption of recombinant human growth hormone (rhGH) from the…”
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EEG burst suppression with propofol during cardiopulmonary bypass in children: a study of the haemodynamic, metabolic and endocrine effects by Laycock, G J, Mitchell, I M, Paton, R D, Donaghey, S F, Logan, R W, Morton, N S

“…We have studied the effects of propofol, given to maintain EEG suppression throughout cardiopulmonary bypass (CPB), in 20 children aged 1-15 yr, in a parallel…”
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Melatonin state in Mendenhall's syndrome by Rittey, C D, Evans, T J, Gray, C E, Paton, R D, Bojkowski, C

“…We report a case of Mendenhall's syndrome that presented as hypoglycaemia. The clinical and biochemical features of the case are described including, for the…”
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Enzymatic conversion of dihydroneopterin triphosphate to the pyrimidodiazepine intermediate involved in the biosynthesis of the drosopterins in Drosophila melanogaster by Wiederrecht, G J, Paton, D R, Brown, G M

“…The compound 2-amino-4-oxo-6-acetyl-7,8-dihydro-3H,9H-pyrimido[4,5-b]-[1,4]diazepine (pyrimidodiazepine or PDA, for short) is a precursor of the red eye…”
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isolation and identification of an intermediate involved in the biosynthesis of drosopterin in Drosophila melanogaster by Wiederrecht, G.J, Paton, D.R, Brown, G.M

“…A compound that is involved in the biosynthesis of the drosopterin eye pigments has been isolated from the heads of Drosophila melanogaster. Analyses of this…”
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C-reactive protein and cardiopulmonary bypass in infants under 5 kilograms by Mitchell, I M, Pollock, J C, Jamieson, M P, Donaghey, S F, Paton, R D, Logan, R W

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Amniotic fluid phosphatidylglycerol and the lecithin/sphingomyelin ratio in the assessment of fetal lung maturity by Whittle, M J, Wilson, A I, Whitfield, C R, Paton, R D, Logan, R W

“…Based on the analysis of 561 amniotic fluid samples obtained within 72 h of delivery, including 288 samples collected from the vagina, the detection of…”
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Neonatal endothelin-1 concentrations in term infants by Macdonald, P D, Paton, R D, Logan, R W

“…Endothelin-1 concentrations were studied in 30 term infants during the first week of life using a radioimmunoassay kit. A neonatal reference range was…”
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Amniotic fluid phospholipid profile determined by two-dimensional thin-layer chromatography as index of fetal lung maturation by Whittle, M J, Wilson, A I, Whitfield, C R, Paton, R D, Logan, R W

“…A phospholipid profile, the main features of which were the lecithin/sphingomyelin (L/S) ratio and the presence or absence of phosphatidylglycerol (PG), was…”
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HPLC of phospholipids in biological fluids -- application to amniotic fluid for the prediction of fetal lung maturity by Paton, R D, McGillivray, A I, Speir, T F, Whittle, M J, Whitfield, C R, Logan, R W

“…Because of both the advantage of speed compared with thin layer chromatography (TLC) and the dearth of high pressure liquid chromatography (HPLC) methods for…”
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