Search Results - "Paton, Louise N"

Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin by Peskin, Alexander V., Pace, Paul E., Behring, Jessica B., Paton, Louise N., Soethoudt, Marjolein, Bachschmid, Markus M., Winterbourn, Christine C.

“…Peroxiredoxin 2 (Prx2) is a thiol protein that functions as an antioxidant, regulator of cellular peroxide concentrations, and sensor of redox signals. Its…”
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The High Reactivity of Peroxiredoxin 2 with H2O2 Is Not Reflected in Its Reaction with Other Oxidants and Thiol Reagents by Peskin, Alexander V., Low, Felicia M., Paton, Louise N., Maghzal, Ghassan J., Hampton, Mark B., Winterbourn, Christine C.

“…Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is important in antioxidant defense and redox signaling. We have…”
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Inactivation of human myeloperoxidase by hydrogen peroxide by Paumann-Page, Martina, Furtmüller, Paul G., Hofbauer, Stefan, Paton, Louise N., Obinger, Christian, Kettle, Anthony J.

“…•Low H2O2 concentrations: fast but limited inactivation of MPO via Compound I.•High H2O2 concentrations: complete inactivation of MPO via Compound III.•H2O2…”
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Redox Potential and Peroxide Reactivity of Human Peroxiredoxin 3 by Cox, Andrew G, Peskin, Alexander V, Paton, Louise N, Winterbourn, Christine C, Hampton, Mark B

“…Peroxiredoxins (Prxs) are a ubiquitous family of thiol peroxidases that protect cells from peroxides and have a putative role in redox signaling. In this…”
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Peroxidasin protein expression and enzymatic activity in metastatic melanoma cell lines are associated with invasive potential by Paumann-Page, Martina, Kienzl, Nikolaus F., Motwani, Jyoti, Bathish, Boushra, Paton, Louise N., Magon, Nicholas J., Sevcnikar, Benjamin, Furtmüller, Paul G., Traxlmayr, Michael W., Obinger, Christian, Eccles, Mike R., Winterbourn, Christine C.

“…Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma…”
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Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix by Bathish, Boushra, Paumann-Page, Martina, Paton, Louise N., Kettle, Anthony J., Winterbourn, Christine C.

“…Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink…”
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Hyperoxidation of peroxiredoxins 2 and 3: rate constants for the reactions of the sulfenic acid of the peroxidatic cysteine by Peskin, Alexander V, Dickerhof, Nina, Poynton, Rebecca A, Paton, Louise N, Pace, Paul E, Hampton, Mark B, Winterbourn, Christine C

“…Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a sulfenic acid, which then condenses with the resolving cysteine of the adjacent Prx in…”
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Formation of Calprotectin-Derived Peptides in the Airways of Children with Cystic Fibrosis by Edwards, Teagan S, Dickerhof, Nina, Magon, Nicholas J, Paton, Louise N, Sly, Peter D, Kettle, Anthony J

“…Calprotectin is released by activated neutrophils along with myeloperoxidase (MPO) and proteases. It plays numerous roles in inflammation and infection, and is…”
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Cardiac effects of myoregulin in ischemia-reperfusion by Appleby, Sarah, Aitken-Buck, Hamish M., Holdaway, Mark S., Byers, Mathew S., Frampton, Chris M., Paton, Louise N., Richards, A. Mark, Lamberts, Regis R., Pemberton, Christopher J.

“…Myoregulin is a recently discovered micropeptide that controls calcium levels by inhibiting the intracellular calcium pump sarco-endoplasmic reticulum…”
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Interaction of adenanthin with glutathione and thiol enzymes: Selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling by Soethoudt, Marjolein, Peskin, Alexander V., Dickerhof, Nina, Paton, Louise N., Pace, Paul E., Winterbourn, Christine C.

“…The diterpenoid, adenanthin, represses tumor growth and prolongs survival in mouse promyelocytic leukemia models (Liu et al., Nat. Chem. Biol. 8, 486, 2012)…”
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2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation by Tidén, Anna-Karin, Sjögren, Tove, Svensson, Mats, Bernlind, Alexandra, Senthilmohan, Revathy, Auchère, Francoise, Norman, Henrietta, Markgren, Per-Olof, Gustavsson, Susanne, Schmidt, Staffan, Lundquist, Stefan, Forbes, Louisa V., Magon, Nicholas J., Paton, Louise N., Jameson, Guy N.L., Eriksson, Håkan, Kettle, Anthony J.

“…Myeloperoxidase (MPO) is a prime candidate for promoting oxidative stress during inflammation. This abundant enzyme of neutrophils uses hydrogen peroxide to…”
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Increased thrombin-induced polymerization of fibrinogen associated with high protein carbonyl levels in plasma from patients post myocardial infarction by Paton, Louise N., Mocatta, Tessa J., Richards, A. Mark, Winterbourn, Christine C.

“…Increased levels of protein carbonyls have been measured in plasma of patients following a myocardial infarction (Mocatta et al. J. Am. Coll. Cardiol…”
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The differential expression of proteins in the cortical cells of wool and hair fibres by Plowman, Jeffrey E., Paton, Louise N., Bryson, Warren G.

“…:  Three different cell types have been identified in the cortex of wool: orthocortex, mesocortex and paracortex. Fine wool fibres, particularly Merino sheep,…”
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Correction to Redox Potential and Peroxide Reactivity of Human Peroxiredoxin 3 by Cox, Andrew G, Peskin, Alexander V, Paton, Louise N, Winterbourn, Christine C, Hampton, Mark B

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Investigations into charge heterogeneity of wool intermediate filament proteins by Paton, Louise N., Gerrard, Juliet A., Bryson, Warren G.

“…Genomic studies have shown that there are four abundant type I and type II intermediate filament proteins (IFPs) in wool. When separated using 2D-PAGE, the…”
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Two-dimensional gel electrophoresis of wool intermediate filament proteins by Paton, Louise N., Gerrard, Juliet A., Bryson, Warren G.

“…Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) methods have been used to provide high-resolution separation of wool intermediate filament…”
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The effect of oxidation or alkylation on the separation of wool keratin proteins by two-dimensional gel electrophoresis by Plowman, Jeffrey E., Flanagan, Leanne M., Paton, Louise N., Fitzgerald, Anna C., Joyce, Nigel I., Bryson, Warren G.

“…Comparative two‐dimensional electrophoretic (2‐DE) studies were performed over a time‐course to examine the effect of oxidation or alkylation on the separation…”
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Hyperoxidation of Peroxiredoxins 2 and 3 by Peskin, Alexander V., Dickerhof, Nina, Poynton, Rebecca A., Paton, Louise N., Pace, Paul E., Hampton, Mark B., Winterbourn, Christine C.

“…Typical 2-Cys peroxiredoxins (Prxs) react rapidly with H2O2 to form a sulfenic acid, which then condenses with the resolving cysteine of the adjacent Prx in…”
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The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents by Peskin, Alexander V, Low, Felicia M, Paton, Louise N, Maghzal, Ghassan J, Hampton, Mark B, Winterbourn, Christine C

“…Peroxiredoxin 2 is a member of the mammalian peroxiredoxin family of thiol proteins that is important in antioxidant defense and redox signaling. We have…”
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