Search Results - "Paton, J. F. R."

Spatial and Functional Architecture of the Mammalian Brain Stem Respiratory Network: A Hierarchy of Three Oscillatory Mechanisms by Smith, J. C, Abdala, A. P. L, Koizumi, H, Rybak, I. A, Paton, J. F. R

“…1 Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland; 2…”
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The sympathetic nervous system and blood pressure in humans: implications for hypertension by Fisher, J P, Paton, J F R

“…A neurogenic component to primary hypertension (hypertension) is now well established. Along with raised vasomotor tone and increased cardiac output, the…”
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Reverse re-modelling chronic heart failure by reinstating heart rate variability by Shanks, J., Abukar, Y., Lever, N. A., Pachen, M., LeGrice, I. J., Crossman, D. J., Nogaret, A., Paton, J. F. R., Ramchandra, R.

“…Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart…”
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Quantifying sympathetic neuro‐haemodynamic transduction at rest in humans: insights into sex, ageing and blood pressure control by Briant, L. J. B., Burchell, A. E., Ratcliffe, L. E. K., Charkoudian, N., Nightingale, A. K., Paton, J. F. R., Joyner, Michael J., Hart, E. C.

“…Key points We have developed a simple analytical method for quantifying the transduction of sympathetic activity into vascular tone. This method demonstrates…”
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Evaluating the physiological significance of respiratory sinus arrhythmia: looking beyond ventilation–perfusion efficiency by Ben‐Tal, A., Shamailov, S. S., Paton, J. F. R.

“…Key points  •  Respiratory sinus arrhythmia (RSA) is the variation of heart rate with breathing: heart rate increases during inspiration and decreases during…”
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Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii by Polson, J W, Dampney, R A L, Boscan, P, Pickering, A E, Paton, J F R

“…Microinjection of angiotensin II into the nucleus tractus solitarii attenuates the baroreceptor reflex-mediated bradycardia by inhibiting both vagal and…”
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Abdominal expiratory activity in the rat brainstem–spinal cord in situ: patterns, origins and implications for respiratory rhythm generation by Abdala, A. P. L., Rybak, I. A., Smith, J. C., Paton, J. F. R.

“…We studied respiratory neural activity generated during expiration. Motoneuronal activity was recorded simultaneously from abdominal (AbN), phrenic (PN),…”
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Dehydration-Induced Proteome Changes in the Rat Hypothalamo-Neurohypophyseal System by Gouraud, S. S, Heesom, K, Yao, S. T, Qiu, J, Paton, J. F. R, Murphy, D

“…The hypothalamo-neurohypophyseal system (HNS) mediates neuroendocrine responses to dehydration through the action of the antidiuretic hormone vasopressin (VP)…”
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DEEP BRAIN STIMULATION RELIEVES REFRACTORY HYPERTENSION by PATEL, N. K, JAVED, S, KHAN, S, PAPOUCHADO, M, MALIZIA, A. L, PICKERING, A. E, PATON, J. F. R

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Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats by McBryde, F. D., Liu, B. H., Roloff, E. V., Kasparov, S., Paton, J. F. R.

“…New Findings What is the central question of this study? Does chronic reduction of neuronally generated nitric oxide in the hypothalamic paraventricular…”
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Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing ‘Cushing's mechanism’ by Paton, J. F. R., Dickinson, C. J., Mitchell, G.

“…The fundamental mechanism that underlies essential hypertension is a high total peripheral resistance. We review here possible origins of high total peripheral…”
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The effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance by Rodrigues, J C L, McIntyre, B, Dastidar, A G, Lyen, S M, Ratcliffe, L E, Burchell, A E, Hart, E C, Bucciarelli-Ducci, C, Hamilton, M C K, Paton, J F R, Nightingale, A K, Manghat, N E

“…Electrocardiograph (ECG) criteria for left ventricular hypertrophy (LVH) are a widely used clinical tool. We recalibrated six ECG criteria for LVH against…”
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Identification of an immune-responsive mesolimbocortical serotonergic system: Potential role in regulation of emotional behavior by Lowry, C.A, Hollis, J.H, de Vries, A, Pan, B, Brunet, L.R, Hunt, J.R.F, Paton, J.F.R, van Kampen, E, Knight, D.M, Evans, A.K, Rook, G.A.W, Lightman, S.L

“…Abstract Peripheral immune activation can have profound physiological and behavioral effects including induction of fever and sickness behavior. One mechanism…”
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The Hypothalamic-Neurohypophyseal System: From Genome to Physiology by Murphy, D., Konopacka, A., Hindmarch, C., Paton, J. F. R., Sweedler, J. V., Gillette, M. U., Ueta, Y., Grinevich, V., Lozic, M., Japundzic-Zigon, N.

“…The elucidation of the genomes of a large number of mammalian species has produced a huge amount of data on which to base physiological studies. These…”
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A spinal vasopressinergic mechanism mediates hyperosmolality-induced sympathoexcitation by Antunes, V. R., Yao, S. T., Pickering, A. E., Murphy, D., Paton, J. F. R.

“…An elevation in plasma osmolality elicits a complex neurohumoral response, including an activation of the sympathetic nervous system and an increase in…”
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The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances by Dutschmann, M., Waki, H., Manzke, T., Simms, A. E., Pickering, A. E., Richter, D. W., Paton, J. F. R.

“…R in ponto-medullary cardiorespiratory networks was identified using histochemistry. Systemic administration of the μ-OR agonist fentanyl…”
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Lactate-mediated glia-neuronal signalling in the mammalian brain by Tang, F., Lane, S., Korsak, A., Paton, J. F. R., Gourine, A. V., Kasparov, S., Teschemacher, A. G.

“…Astrocytes produce and release L -lactate as a potential source of energy for neurons. Here we present evidence that L -lactate, independently of its caloric…”
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A cardiovascular role for fractalkine and its cognate receptor, CX3CR1, in the rat nucleus of the solitary tract by Ruchaya, P.J, Paton, J.F.R, Murphy, D, Yao, S.T

“…Abstract The nucleus of the solitary tract (NTS), an integral vasomotor region located in the hindbrain, is important for cardiovascular homeostasis…”
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Glycinergic inhibition is essential for co-ordinating cranial and spinal respiratory motor outputs in the neonatal rat by Dutschmann, M., Paton, J. F. R.

“…Eupnoeic breathing in mammals is dependent on the co-ordinated activity of cranial and spinal motor outputs to both ventilate the lungs and adjust respiratory…”
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Selective Up-Regulation of JunD Transcript and Protein Expression in Vasopressinergic Supraoptic Nucleus Neurones in Water-Deprived Rats by Yao, S. T., Gouraud, S. S., Qiu, J., Cunningham, J. T., Paton, J. F. R., Murphy, D.

“…The magnocellular neurones (MCN) of the supraoptic nucleus (SON) undergo reversible changes during dehydration. We hypothesise that alterations in steady‐state…”
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