Search Results - "Paton, C"

Glycointeractions in bacterial pathogenesis by Poole, Jessica, Day, Christopher J., von Itzstein, Mark, Paton, James C., Jennings, Michael P.

“…Many important interactions between bacterial pathogens and their hosts are highly specific binding events that involve host or pathogen carbohydrate…”
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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis by Lu, Min, Lawrence, David A., Marsters, Scot, Acosta-Alvear, Diego, Kimmig, Philipp, Mendez, Aaron S., Paton, Adrienne W., Paton, James C., Walter, Peter, Ashkenazi, Avi

“…Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the…”
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A molecular mechanism for bacterial susceptibility to zinc by McDevitt, Christopher A, Ogunniyi, Abiodun D, Valkov, Eugene, Lawrence, Michael C, Kobe, Bostjan, McEwan, Alastair G, Paton, James C

“…Transition row metal ions are both essential and toxic to microorganisms. Zinc in excess has significant toxicity to bacteria, and host release of Zn(II) at…”
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The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease by Kadioglu, Aras, Weiser, Jeffrey N, Paton, James C, Andrew, Peter W

“…Key Points Streptococcus pneumoniae (commonly referred to as the pneumococcus) interacts with numerous host structures during respiratory colonization, and…”
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GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells by Nain, Minu, Mukherjee, Sriparna, Karmakar, Sonali Porey, Paton, Adrienne W, Paton, James C, Abdin, M Z, Basu, Anirban, Kalia, Manjula, Vrati, Sudhanshu

“…Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the leading cause of viral encephalitis in Southeast Asia with potential to become a global…”
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Can seawater desalination be a win-win fix to our water cycle? by Pistocchi, A., Bleninger, T., Breyer, C., Caldera, U., Dorati, C., Ganora, D., Millán, M.M., Paton, C., Poullis, D., Herrero, F. Salas, Sapiano, M., Semiat, R., Sommariva, C., Yuece, S., Zaragoza, G.

“…While we increasingly turn to desalination as a secure water supply, it is still perceived as an expensive and environmentally damaging solution, affordable…”
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Extracellular zinc competitively inhibits manganese uptake and compromises oxidative stress management in Streptococcus pneumoniae by Eijkelkamp, Bart A, Morey, Jacqueline R, Ween, Miranda P, Ong, Cheryl-lynn Y, McEwan, Alastair G, Paton, James C, McDevitt, Christopher A

“…Streptococcus pneumoniae requires manganese for colonization of the human host, but the underlying molecular basis for this requirement has not been…”
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Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface by Brown, Max, Dainty, Samantha, Strudwick, Natalie, Mihai, Adina D, Watson, Jamie N, Dendooven, Robina, Paton, Adrienne W, Paton, James C, Schröder, Martin

“…Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates a signaling network known as the unfolded protein response…”
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Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier by Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard

“…Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC…”
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Modelling the Wolbachia incompatible insect technique: strategies for effective mosquito population elimination by Pagendam, D E, Trewin, B J, Snoad, N, Ritchie, S A, Hoffmann, A A, Staunton, K M, Paton, C, Beebe, N

“…The Wolbachia incompatible insect technique (IIT) shows promise as a method for eliminating populations of invasive mosquitoes such as Aedes aegypti (Linnaeus)…”
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The central role of arginine in Haemophilus influenzae survival in a polymicrobial environment with Streptococcus pneumoniae and Moraxella catarrhalis by Tikhomirova, Alexandra, Zilm, Peter S, Trappetti, Claudia, Paton, James C, Kidd, Stephen P

“…Haemophilus influenzae , Streptococcus pneumoniae and Moraxella catarrhalis are bacterial species which frequently co-colonise the nasopharynx, but can also…”
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IL-17-producing γδ T cells switch migratory patterns between resting and activated states by McKenzie, Duncan R., Kara, Ervin E., Bastow, Cameron R., Tyllis, Timona S., Fenix, Kevin A., Gregor, Carly E., Wilson, Jasmine J., Babb, Rachelle, Paton, James C., Kallies, Axel, Nutt, Stephen L., Brüstle, Anne, Mack, Matthias, Comerford, Iain, McColl, Shaun R.

“…Interleukin 17-producing γδ T (γδT17) cells have unconventional trafficking characteristics, residing in mucocutaneous tissues but also homing into inflamed…”
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Streptococcus pneumoniae induces pyroptosis through the regulation of autophagy in murine microglia by Kim, Ji-Yun, Paton, James C, Briles, David E, Rhee, Dong-Kwon, Pyo, Suhkneung

“…Streptococcus pneumoniae is responsible for significant mortality and morbidity worldwide and causes invasive pneumococcal diseases including pneumococcal…”
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Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import by Schorr, Stefan, Nguyen, Duy, Haßdenteufel, Sarah, Nagaraj, Nagarjuna, Cavalié, Adolfo, Greiner, Markus, Weissgerber, Petra, Loi, Marisa, Paton, Adrienne W., Paton, James C., Molinari, Maurizio, Förster, Friedrich, Dudek, Johanna, Lang, Sven, Helms, Volkhard, Zimmermann, Richard

“…In mammalian cells, one‐third of all polypeptides are integrated into the membrane or translocated into the lumen of the endoplasmic reticulum (ER) via the…”
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BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment by Cooper, Stephen J, Reynolds, Gavin P, Barnes, TRE, England, E, Haddad, PM, Heald, A, Holt, RIG, Lingford-Hughes, A, Osborn, D, McGowan, O, Patel, MX, Paton, C, Reid, P, Shiers, D, Smith, J

“…Excess deaths from cardiovascular disease are a major contributor to the significant reduction in life expectancy experienced by people with schizophrenia…”
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Streptococcus pneumoniae Uses Glutathione To Defend against Oxidative Stress and Metal Ion Toxicity by Potter, Adam J, Trappetti, Claudia, Paton, James C

“…The thiol-containing tripeptide glutathione is an important cellular constituent of many eukaryotic and prokaryotic cells. In addition to its disulfide…”
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A random six-phase switch regulates pneumococcal virulence via global epigenetic changes by Manso, Ana Sousa, Chai, Melissa H., Atack, John M., Furi, Leonardo, De Ste Croix, Megan, Haigh, Richard, Trappetti, Claudia, Ogunniyi, Abiodun D., Shewell, Lucy K., Boitano, Matthew, Clark, Tyson A., Korlach, Jonas, Blades, Matthew, Mirkes, Evgeny, Gorban, Alexander N., Paton, James C., Jennings, Michael P., Oggioni, Marco R.

“…Streptococcus pneumoniae (the pneumococcus) is the world’s foremost bacterial pathogen in both morbidity and mortality. Switching between phenotypic forms (or…”
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Proinsulin misfolding is an early event in the progression to type 2 diabetes by Arunagiri, Anoop, Haataja, Leena, Pottekat, Anita, Pamenan, Fawnnie, Kim, Soohyun, Zeltser, Lori M, Paton, Adrienne W, Paton, James C, Tsai, Billy, Itkin-Ansari, Pamela, Kaufman, Randal J, Liu, Ming, Arvan, Peter

“…Biosynthesis of insulin - critical to metabolic homeostasis - begins with folding of the proinsulin precursor, including formation of three evolutionarily…”
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Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury by McDonald, Courtney A, Penny, Tayla R, Paton, Madison C B, Sutherland, Amy E, Nekkanti, Lakshmi, Yawno, Tamara, Castillo-Melendez, Margie, Fahey, Michael C, Jones, Nicole M, Jenkin, Graham, Miller, Suzanne L

“…It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent…”
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ZnuA and zinc homeostasis in Pseudomonas aeruginosa by Pederick, Victoria G., Eijkelkamp, Bart A., Begg, Stephanie L., Ween, Miranda P., McAllister, Lauren J., Paton, James C., McDevitt, Christopher A.

“…Pseudomonas aeruginosa is a ubiquitous environmental bacterium and a clinically significant opportunistic human pathogen. Central to the ability of P…”
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