Search Results - "Paton, Adrienne W."

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis by Lu, Min, Lawrence, David A., Marsters, Scot, Acosta-Alvear, Diego, Kimmig, Philipp, Mendez, Aaron S., Paton, Adrienne W., Paton, James C., Walter, Peter, Ashkenazi, Avi

“…Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the…”
Get full text

GRP78 Is an Important Host Factor for Japanese Encephalitis Virus Entry and Replication in Mammalian Cells by Nain, Minu, Mukherjee, Sriparna, Karmakar, Sonali Porey, Paton, Adrienne W, Paton, James C, Abdin, M Z, Basu, Anirban, Kalia, Manjula, Vrati, Sudhanshu

“…Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is the leading cause of viral encephalitis in Southeast Asia with potential to become a global…”
Get full text

Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface by Brown, Max, Dainty, Samantha, Strudwick, Natalie, Mihai, Adina D, Watson, Jamie N, Dendooven, Robina, Paton, Adrienne W, Paton, James C, Schröder, Martin

“…Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates a signaling network known as the unfolded protein response…”
Get full text

Chaperone-Mediated Sec61 Channel Gating during ER Import of Small Precursor Proteins Overcomes Sec61 Inhibitor-Reinforced Energy Barrier by Haßdenteufel, Sarah, Johnson, Nicholas, Paton, Adrienne W., Paton, James C., High, Stephen, Zimmermann, Richard

“…Protein transport into the mammalian endoplasmic reticulum (ER) is mediated by the heterotrimeric Sec61 channel. The signal recognition particle (SRP) and TRC…”
Get full text

Identification of signal peptide features for substrate specificity in human Sec62/Sec63‐dependent ER protein import by Schorr, Stefan, Nguyen, Duy, Haßdenteufel, Sarah, Nagaraj, Nagarjuna, Cavalié, Adolfo, Greiner, Markus, Weissgerber, Petra, Loi, Marisa, Paton, Adrienne W., Paton, James C., Molinari, Maurizio, Förster, Friedrich, Dudek, Johanna, Lang, Sven, Helms, Volkhard, Zimmermann, Richard

“…In mammalian cells, one‐third of all polypeptides are integrated into the membrane or translocated into the lumen of the endoplasmic reticulum (ER) via the…”
Get full text

Proinsulin misfolding is an early event in the progression to type 2 diabetes by Arunagiri, Anoop, Haataja, Leena, Pottekat, Anita, Pamenan, Fawnnie, Kim, Soohyun, Zeltser, Lori M, Paton, Adrienne W, Paton, James C, Tsai, Billy, Itkin-Ansari, Pamela, Kaufman, Randal J, Liu, Ming, Arvan, Peter

“…Biosynthesis of insulin - critical to metabolic homeostasis - begins with folding of the proinsulin precursor, including formation of three evolutionarily…”
Get full text

Stress-induced protein disaggregation in the endoplasmic reticulum catalysed by BiP by Melo, Eduardo Pinho, Konno, Tasuku, Farace, Ilaria, Awadelkareem, Mosab Ali, Skov, Lise R., Teodoro, Fernando, Sancho, Teresa P., Paton, Adrienne W., Paton, James C., Fares, Matthew, Paulo, Pedro M. R., Zhang, Xin, Avezov, Edward

“…Protein synthesis is supported by cellular machineries that ensure polypeptides fold to their native conformation, whilst eliminating misfolded, aggregation…”
Get full text

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization by Tang, Chih-Hang Anthony, Chang, Shiun, Paton, Adrienne W, Paton, James C, Gabrilovich, Dmitry I, Ploegh, Hidde L, Del Valle, Juan R, Hu, Chih-Chi Andrew

“…To relieve endoplasmic reticulum (ER) stress, IRE1 splices XBP1 messenger RNA (mRNA) or engages regulated IRE1-dependent decay (RIDD) of other mRNAs. Upon XBP1…”
Get full text

DR5 and caspase-8 are dispensable in ER stress-induced apoptosis by Glab, Jason A, Doerflinger, Marcel, Nedeva, Christina, Jose, Irvin, Mbogo, George W, Paton, James C, Paton, Adrienne W, Kueh, Andrew J, Herold, Marco J, Huang, David CS, Segal, David, Brumatti, Gabriella, Puthalakath, Hamsa

“…The endoplasmic reticulum (ER) stress response constitutes cellular reactions triggered by a wide variety of stimuli that disturb folding of proteins, often…”
Get full text

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling by Fenech, Emma J, Lari, Federica, Charles, Philip D, Fischer, Roman, Laétitia-Thézénas, Marie, Bagola, Katrin, Paton, Adrienne W, Paton, James C, Gyrd-Hansen, Mads, Kessler, Benedikt M, Christianson, John C

“…Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium…”
Get full text

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury by Leonard, Antony, Grose, Valerie, Paton, Adrienne W., Paton, James C., Yule, David I., Rahman, Arshad, Fazal, Fabeha

“…The role of Endoplasmic Reticulum Chaperone and Signaling Regulator BiP/GRP78 in acute inflammatory injury, particularly in the context of lung endothelium, is…”
Get full text

BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER by Schäuble, Nico, Lang, Sven, Jung, Martin, Cappel, Sabine, Schorr, Stefan, Ulucan, Özlem, Linxweiler, Johannes, Dudek, Johanna, Blum, Robert, Helms, Volkhard, Paton, Adrienne W, Paton, James C, Cavalié, Adolfo, Zimmermann, Richard

“…In mammalian cells, signal peptide‐dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic protein‐conducting channel, the…”
Get full text

LuxS Mediates Iron-Dependent Biofilm Formation, Competence, and Fratricide in Streptococcus pneumoniae by TRAPPETTI, Claudia, POTTER, Adam J, PATON, Adrienne W, OGGIONI, Marco R, PATON, James C

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD by Song, Zhenfeng, Thepsuwan, Pattaraporn, Hur, Woosuk Steve, Torres, Mauricio, Wu, Shuangcheng Alivia, Wei, Xiaoqiong, Tushi, Nusrat Jahan, Wei, Juncheng, Ferraresso, Francesca, Paton, Adrienne W., Paton, James C., Zheng, Ze, Zhang, Kezhong, Fang, Deyu, Kastrup, Christian J., Jaiman, Sunil, Flick, Matthew James, Sun, Shengyi

“…Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic fibrinogen storage disease (HFSD), characterized by the presence of…”
Get full text

ER-Stress-Induced Differentiation Sensitizes Colon Cancer Stem Cells to Chemotherapy by Wielenga, Mattheus C.B., Colak, Selcuk, Heijmans, Jarom, van Lidth de Jeude, Jooske F., Rodermond, Hans M., Paton, James C., Paton, Adrienne W., Vermeulen, Louis, Medema, Jan Paul, van den Brink, Gijs R.

“…Colon cancer stem cells (colon-CSCs) are more resistant to conventional chemotherapy than differentiated cancer cells. This subset of therapy refractory cells…”
Get full text

cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity by Shewell, Lucy K, Harvey, Richard M, Higgins, Melanie A, Day, Christopher J, Hartley-Tassell, Lauren E, Chen, Austen Y, Gillen, Christine M, James, David B A, Alonzo, 3rd, Francis, Torres, Victor J, Walker, Mark J, Paton, Adrienne W, Paton, James C, Jennings, Michael P

“…The cholesterol-dependent cytolysin (CDC) pneumolysin (Ply) is a key virulence factor of Streptococcus pneumoniae . Membrane cholesterol is required for the…”
Get full text

ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis by Fucho, Raquel, Martínez, Laura, Baulies, Anna, Torres, Sandra, Tarrats, Nuria, Fernandez, Anna, Ribas, Vicente, Astudillo, Alma M, Balsinde, Jesús, Garcia-Rovés, Pablo, Elena, Montserrat, Bergheim, Ina, Lotersztajn, Sophie, Trautwein, Christian, Appelqvist, Hanna, Paton, Adrienne W, Paton, James C, Czaja, Mark J, Kaplowitz, Neil, Fernandez-Checa, Jose C, García-Ruiz, Carmen

“…Background & Aims Acid sphingomyelinase (ASMase) is activated in non-alcoholic steatohepatitis (NASH). However, the contribution of ASMase to NASH is poorly…”
Get full text

Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors by Ng, Preston S.K., Böhm, Raphael, Hartley-Tassell, Lauren E., Steen, Jason A., Wang, Hui, Lukowski, Samuel W., Hawthorne, Paula L., Trezise, Ann E.O., Coloe, Peter J., Grimmond, Sean M., Haselhorst, Thomas, von Itzstein, Mark, Paton, Adrienne W., Paton, James C., Jennings, Michael P.

“…Mammals express the sialic acids N -acetylneuraminic acid (Neu5Ac) and N- glycolylneuraminic acid (Neu5Gc) on cell surfaces, where they act as receptors for…”
Get full text

Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation by Leonard, Antony, Paton, Adrienne W, El-Quadi, Monaliza, Paton, James C, Fazal, Fabeha

“…Endoplasmic Reticulum (ER) stress, caused by disturbance in ER homeostasis, has been implicated in several pathological conditions such as ischemic injury,…”
Get full text

Selective Abrogation of BiP/GRP78 Blunts Activation of NF-κB through the ATF6 Branch of the UPR: Involvement of C/EBPβ and mTOR-Dependent Dephosphorylation of Akt by Nakajima, Shotaro, Hiramatsu, Nobuhiko, Hayakawa, Kunihiro, Saito, Yukinori, Kato, Hironori, Huang, Tao, Yao, Jian, Paton, Adrienne W., Paton, James C., Kitamura, Masanori

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text