Search Results - "Pato, Michele T."

Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies by Arnedo, Javier, Svrakic, Dragan M., del Val, Coral, Romero-Zaliz, Rocío, Hernández-Cuervo, Helena, Fanous, Ayman H., Pato, Michele T., Pato, Carlos N., de Erausquin, Gabriel A., Cloninger, C. Robert, Zwir, Igor

“…Objective:The authors sought to demonstrate that schizophrenia is a heterogeneous group of heritable disorders caused by different genotypic networks that…”
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Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology by Tung, Victoria Sook Keng, Mathews, Fasil, Boruk, Marina, Suppa, Gabrielle, Foronjy, Robert, Pato, Michele T, Pato, Carlos N, Knowles, James A, Evgrafov, Oleg V

“…The study of neurodevelopmental molecular mechanisms in schizophrenia requires the development of adequate biological models such as patient-derived cells and…”
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Genetic correlation between smoking behaviors and schizophrenia by Hartz, Sarah M, Horton, Amy C, Hancock, Dana B, Baker, Timothy B, Caporaso, Neil E, Chen, Li-Shiun, Hokanson, John E, Lutz, Sharon M, Marazita, Mary L, McNeil, Daniel W, Pato, Carlos N, Pato, Michele T, Johnson, Eric O, Bierut, Laura J

“…Abstract Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic…”
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A comprehensive family-based replication study of schizophrenia genes by Aberg, Karolina A, Liu, Youfang, Bukszár, Jozsef, McClay, Joseph L, Khachane, Amit N, Andreassen, Ole A, Blackwood, Douglas, Corvin, Aiden, Djurovic, Srdjan, Gurling, Hugh, Ophoff, Roel, Pato, Carlos N, Pato, Michele T, Riley, Brien, Webb, Todd, Kendler, Kenneth, O'Donovan, Mick, Craddock, Nick, Kirov, George, Owen, Mike, Rujescu, Dan, St Clair, David, Werge, Thomas, Hultman, Christina M, Delisi, Lynn E, Sullivan, Patrick, van den Oord, Edwin J

“…Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is…”
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A Rare Functional Noncoding Variant at the GWAS-Implicated MIR137/MIR2682 Locus Might Confer Risk to Schizophrenia and Bipolar Disorder by Duan, Jubao, Shi, Jianxin, Fiorentino, Alessia, Leites, Catherine, Chen, Xiangning, Moy, Winton, Chen, Jingchun, Alexandrov, Boian S., Usheva, Anny, He, Deli, Freda, Jessica, O’Brien, Niamh L., Gejman, Pablo V., Sanders, Alan R., Duan, Jubao, Levinson, Douglas F., Shi, Jianxin, Buccola, Nancy G., Mowry, Bryan J., Freedman, Robert, Olincy, Ann, Amin, Farooq, Black, Donald W., Silverman, Jeremy M., Byerley, William F., Svrakic, Dragan M., Cloninger, C. Robert, Pato, Michele T., Sobell, Janet L., Medeiros, Helena, Abbott, Colony, Skar, Brooke, Buckley, Peter F., Bromet, Evelyn J., Escamilla, Michael A., Fanous, Ayman H., Lehrer, Douglas S., Macciardi, Fabio, Malaspina, Dolores, McCarroll, Steve A., Marder, Stephen R., Moran, Jennifer, Morley, Christopher P., Nicolini, Humberto, Perkins, Diana O., Purcell, Shaun M., Rapaport, Mark H., Sklar, Pamela, Smoller, Jordan W., Knowles, James A., Pato, Carlos N., McQuillin, Andrew, Sanders, Alan R., Gershon, Elliot S., DeLisi, Lynn E., Bishop, Alan R., Gurling, Hugh M.D., Pato, Michele T., Levinson, Douglas F., Kendler, Kenneth S., Pato, Carlos N., Gejman, Pablo V.

“…Schizophrenia (SZ) genome-wide association studies (GWASs) have identified common risk variants in >100 susceptibility loci; however, the contribution of rare…”
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Risk for alcohol use problems in severe mental illness: Interactions with sex and racial/ethnic minority status by Levit, Jeremy D., Meyers, Jacquelyn L., Georgakopoulos, Penelope, Pato, Michele T.

“…Alcohol use disorder (AUD) is exceedingly common among individuals with bipolar disorder and schizophrenia. However, studies on alcohol use in psychiatric…”
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Traumatic events in childhood and adulthood in a diverse-ancestry sample and their role in bipolar disorder by Chen, Qianwei, Kumar, Vandana, Mummini, Swetha, Pato, Carlos N., Pato, Michele T.

“…•Individuals with BD reported having experienced more childhood and lifetime adverse events.•Individuals with BD had a higher prevalence of PTSD.•Among all the…”
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Changing Recruitment Outcomes: The “Why” and The “How” by MacLean, Lisa, Pato, Michèle T.

“…Objective Residency programs compete for applicants and commit extensive resources to the recruitment process. After failing to fill in the match for 5 years…”
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Comorbidity of severe psychotic disorders with measures of substance use by Hartz, Sarah M, Pato, Carlos N, Medeiros, Helena, Cavazos-Rehg, Patricia, Sobell, Janet L, Knowles, James A, Bierut, Laura J, Pato, Michele T

“…Although early mortality in severe psychiatric illness is linked to smoking and alcohol, to our knowledge, no studies have comprehensively characterized…”
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Diagnosis and Treatment of Obsessive-Compulsive and Related Disorders by Pato, Michele T

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Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population by Fanous, Ayman H., Middleton, Frank A., Gentile, Karen, Amdur, Richard L., Maher, Brion S., Zhao, Zhongming, Sun, Jingchun, Medeiros, Helena, Carvalho, Celia, Ferreira, Susana R., Macedo, Antonio, Knowles, James A., Azevedo, Maria H., Pato, Michele T., Pato, Carlos N.

“…Recent family and genome‐wide association studies strongly suggest shared genetic risk factors for schizophrenia (SZ) and bipolar disorder (BP). However,…”
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The neurocognitive and functional profile of schizophrenia in a genetically homogenous European sample by da Motta, Carolina, Pato, Michele T., Barreto Carvalho, Célia, Castilho, Paula

“…•We explore several neurocognitive and functional impairments of schizophrenia.•3 samples at different risk levels were compared.•Memory, executive function,…”
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Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study by Montano, Carolina, Taub, Margaret A, Jaffe, Andrew, Briem, Eirikur, Feinberg, Jason I, Trygvadottir, Rakel, Idrizi, Adrian, Runarsson, Arni, Berndsen, Birna, Gur, Ruben C, Moore, Tyler M, Perry, Rodney T, Fugman, Doug, Sabunciyan, Sarven, Yolken, Robert H, Hyde, Thomas M, Kleinman, Joel E, Sobell, Janet L, Pato, Carlos N, Pato, Michele T, Go, Rodney C, Nimgaonkar, Vishwajit, Weinberger, Daniel R, Braff, David, Gur, Raquel E, Fallin, Margaret Daniele, Feinberg, Andrew P

“…DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. To scan genome-wide…”
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Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans by Carlson, Jedidiah, Locke, Adam E., Flickinger, Matthew, Zawistowski, Matthew, Levy, Shawn, Myers, Richard M., Boehnke, Michael, Kang, Hyun Min, Scott, Laura J., Li, Jun Z., Zöllner, Sebastian

“…A detailed understanding of the genome-wide variability of single-nucleotide germline mutation rates is essential to studying human genome evolution. Here, we…”
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Greater history of traumatic event exposure and PTSD associated with comorbid body dysmorphic disorder in a large OCD cohort by Valderrama, Jorge, Hansen, Stella Kim, Pato, Carlos, Phillips, Katharine, Knowles, James, Pato, Michele T.

“…•We examine trauma, PTSD, OCD, and OCD with comorbid BDD.•OCD + comorbid BDD associated with higher rates of at least one traumatic life event.•OCD and…”
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Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity by Usher, Christina L, Handsaker, Robert E, Esko, Tõnu, Tuke, Marcus A, Weedon, Michael N, Hastie, Alex R, Cao, Han, Moon, Jennifer E, Kashin, Seva, Fuchsberger, Christian, Metspalu, Andres, Pato, Carlos N, Pato, Michele T, McCarthy, Mark I, Boehnke, Michael, Altshuler, David M, Frayling, Timothy M, Hirschhorn, Joel N, McCarroll, Steven A

“…Steven McCarroll, Joel Hirschhorn and colleagues identify eight common structural forms of the human amylase locus. They measured amylase gene copy number in…”
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Prognostic value of polygenic risk scores for adults with psychosis by Landi, Isotta, Kaji, Deepak A., Cotter, Liam, Van Vleck, Tielman, Belbin, Gillian, Preuss, Michael, Loos, Ruth J. F., Kenny, Eimear, Glicksberg, Benjamin S., Beckmann, Noam D., O’Reilly, Paul, Schadt, Eric E., Achtyes, Eric D., Buckley, Peter F., Lehrer, Douglas, Malaspina, Dolores P., McCarroll, Steven A., Rapaport, Mark H., Fanous, Ayman H., Pato, Michele T., Pato, Carlos N., Bigdeli, Tim B., Nadkarni, Girish N., Charney, Alexander W.

“…Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor…”
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Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing by Hanks, Sarah C., Forer, Lukas, Schönherr, Sebastian, LeFaive, Jonathon, Martins, Taylor, Welch, Ryan, Gagliano Taliun, Sarah A., Braff, David, Johnsen, Jill M., Kenny, Eimear E., Konkle, Barbara A., Laakso, Markku, Loos, Ruth F.J., McCarroll, Steven, Pato, Carlos, Pato, Michele T., Smith, Albert V., Boehnke, Michael, Scott, Laura J., Fuchsberger, Christian

“…Understanding the genetic basis of human diseases and traits is dependent on the identification and accurate genotyping of genetic variants. Deep whole-genome…”
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Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans by Bigdeli, Tim B, Fanous, Ayman H, Li, Yuli, Rajeevan, Nallakkandi, Sayward, Frederick, Genovese, Giulio, Gupta, Rishab, Radhakrishnan, Krishnan, Malhotra, Anil K, Sun, Ning, Lu, Qiongshi, Hu, Yiming, Li, Boyang, Chen, Quan, Mane, Shrikant, Miller, Perry, Cheung, Kei-Hoi, Gur, Raquel E, Greenwood, Tiffany A, Braff, David L, Achtyes, Eric D, Buckley, Peter F, Escamilla, Michael A, Lehrer, Douglas, Malaspina, Dolores P, McCarroll, Steven A, Rapaport, Mark H, Vawter, Marquis P, Pato, Michele T, Pato, Carlos N, Zhao, Hongyu, Kosten, Thomas R, Brophy, Mary, Pyarajan, Saiju, Shi, Yunling, O’Leary, Timothy J, Gleason, Theresa, Przygodzki, Ronald, Muralidhar, Sumitra, Gaziano, J Michael, Huang, Grant D, Concato, John, Siever, Larry J, Aslan, Mihaela, Harvey, Philip D

“…Abstract Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating neuropsychiatric disorders, collectively affecting 2% of the world’s…”
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Rasch model analysis of the Situational Test of Emotional Understanding – brief in a large Portuguese sample by da Motta, Carolina, Castilho, Paula, Pato, Michele T., Barreto Carvalho, Célia

“…The conceptualization of Emotional Intelligence (EI) has a significant impact on the construct’s operationalization and measurement The current study analyses…”
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