Search Results - "Pato, Carlos"

Association between substance use disorder and polygenic liability to schizophrenia by Hartz, Sarah M., MD PhD, Horton, Amy, PhD, Oehlert, Mary, PhD, Carey, Caitlin E., MA, Agrawal, Arpana, PhD, Bogdan, Ryan, PhD, Chen, Li-Shiun, MD MSc, Hancock, Dana B., PhD, Johnson, Eric O., PhD, Pato, Carlos, MD, Pato, Michele, MD, Rice, John P., PhD, Bierut, Laura J., MD

“…Abstract Background There are high levels of comorbidity between schizophrenia and substance use disorder, but little is known about the genetic etiology of…”
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Genetic correlation between smoking behaviors and schizophrenia by Hartz, Sarah M, Horton, Amy C, Hancock, Dana B, Baker, Timothy B, Caporaso, Neil E, Chen, Li-Shiun, Hokanson, John E, Lutz, Sharon M, Marazita, Mary L, McNeil, Daniel W, Pato, Carlos N, Pato, Michele T, Johnson, Eric O, Bierut, Laura J

“…Abstract Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic…”
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Uncovering the Hidden Risk Architecture of the Schizophrenias: Confirmation in Three Independent Genome-Wide Association Studies by Arnedo, Javier, Svrakic, Dragan M., del Val, Coral, Romero-Zaliz, Rocío, Hernández-Cuervo, Helena, Fanous, Ayman H., Pato, Michele T., Pato, Carlos N., de Erausquin, Gabriel A., Cloninger, C. Robert, Zwir, Igor

“…Objective:The authors sought to demonstrate that schizophrenia is a heterogeneous group of heritable disorders caused by different genotypic networks that…”
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Traumatic events in childhood and adulthood in a diverse-ancestry sample and their role in bipolar disorder by Chen, Qianwei, Kumar, Vandana, Mummini, Swetha, Pato, Carlos N., Pato, Michele T.

“…•Individuals with BD reported having experienced more childhood and lifetime adverse events.•Individuals with BD had a higher prevalence of PTSD.•Among all the…”
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Comorbidity of severe psychotic disorders with measures of substance use by Hartz, Sarah M, Pato, Carlos N, Medeiros, Helena, Cavazos-Rehg, Patricia, Sobell, Janet L, Knowles, James A, Bierut, Laura J, Pato, Michele T

“…Although early mortality in severe psychiatric illness is linked to smoking and alcohol, to our knowledge, no studies have comprehensively characterized…”
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Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia by Jia, Peilin, Wang, Lily, Fanous, Ayman H, Pato, Carlos N, Edwards, Todd L, Zhao, Zhongming

“…With the recent success of genome-wide association studies (GWAS), a wealth of association data has been accomplished for more than 200 complex…”
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BCFtools/liftover: an accurate and comprehensive tool to convert genetic variants across genome assemblies by Genovese, Giulio, Rockweiler, Nicole B, Gorman, Bryan R, Bigdeli, Tim B, Pato, Michelle T, Pato, Carlos N, Ichihara, Kiku, McCarroll, Steven A

“…Abstract Motivation Many genetics studies report results tied to genomic coordinates of a legacy genome assembly. However, as assemblies are updated and…”
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Consumer beliefs regarding farmed versus wild fish by Claret, Anna, Guerrero, Luis, Ginés, Rafael, Grau, Amàlia, Hernández, M. Dolores, Aguirre, Enaitz, Peleteiro, José Benito, Fernández-Pato, Carlos, Rodríguez-Rodríguez, Carmen

“…•Consumer beliefs about farmed and wild fish were grouped into four categories•Belief patterns were affected by socio-demographic data and objective…”
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Ancestry-agnostic estimation of DNA sample contamination from sequence reads by Zhang, Fan, Flickinger, Matthew, Taliun, Sarah A Gagliano, Abecasis, Gonçalo R, Scott, Laura J, McCaroll, Steven A, Pato, Carlos N, Boehnke, Michael, Kang, Hyun Min

“…Detecting and estimating DNA sample contamination are important steps to ensure high-quality genotype calls and reliable downstream analysis. Existing methods…”
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Cultured Mesenchymal Cells from Nasal Turbinate as a Cellular Model of the Neurodevelopmental Component of Schizophrenia Etiology by Tung, Victoria Sook Keng, Mathews, Fasil, Boruk, Marina, Suppa, Gabrielle, Foronjy, Robert, Pato, Michele T, Pato, Carlos N, Knowles, James A, Evgrafov, Oleg V

“…The study of neurodevelopmental molecular mechanisms in schizophrenia requires the development of adequate biological models such as patient-derived cells and…”
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Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder by Rodrigues, Joao E, Martinho, Ana, Santos, Vítor, Santa, Catia, Madeira, Nuno, Martins, Maria J, Pato, Carlos N, Macedo, Antonio, Manadas, Bruno

“…Bipolar disorder (BD) is a clinically heterogeneous condition, presenting a complex underlying etiopathogenesis that is not sufficiently characterized. Without…”
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Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study by Montano, Carolina, Taub, Margaret A, Jaffe, Andrew, Briem, Eirikur, Feinberg, Jason I, Trygvadottir, Rakel, Idrizi, Adrian, Runarsson, Arni, Berndsen, Birna, Gur, Ruben C, Moore, Tyler M, Perry, Rodney T, Fugman, Doug, Sabunciyan, Sarven, Yolken, Robert H, Hyde, Thomas M, Kleinman, Joel E, Sobell, Janet L, Pato, Carlos N, Pato, Michele T, Go, Rodney C, Nimgaonkar, Vishwajit, Weinberger, Daniel R, Braff, David, Gur, Raquel E, Fallin, Margaret Daniele, Feinberg, Andrew P

“…DNA methylation may play an important role in schizophrenia (SZ), either directly as a mechanism of pathogenesis or as a biomarker of risk. To scan genome-wide…”
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Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans by Carlson, Jedidiah, Locke, Adam E., Flickinger, Matthew, Zawistowski, Matthew, Levy, Shawn, Myers, Richard M., Boehnke, Michael, Kang, Hyun Min, Scott, Laura J., Li, Jun Z., Zöllner, Sebastian

“…A detailed understanding of the genome-wide variability of single-nucleotide germline mutation rates is essential to studying human genome evolution. Here, we…”
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Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia by Rodrigues, João E, Martinho, Ana, Santa, Catia, Madeira, Nuno, Coroa, Manuel, Santos, Vítor, Martins, Maria J, Pato, Carlos N, Macedo, Antonio, Manadas, Bruno

“…Mass spectrometry (MS)-based techniques can be a powerful tool to identify neuropsychiatric disorder biomarkers, improving prediction and diagnosis ability…”
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The PhenX Toolkit: Get the Most From Your Measures by Hamilton, Carol M., Strader, Lisa C., Pratt, Joseph G., Maiese, Deborah, Hendershot, Tabitha, Kwok, Richard K., Hammond, Jane A., Huggins, Wayne, Jackman, Dean, Pan, Huaqin, Nettles, Destiney S., Beaty, Terri H., Farrer, Lindsay A., Kraft, Peter, Marazita, Mary L., Ordovas, Jose M., Pato, Carlos N., Spitz, Margaret R., Wagener, Diane, Williams, Michelle, Junkins, Heather A., Harlan, William R., Ramos, Erin M., Haines, Jonathan

“…The potential for genome-wide association studies to relate phenotypes to specific genetic variation is greatly increased when data can be combined or compared…”
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Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity by Usher, Christina L, Handsaker, Robert E, Esko, Tõnu, Tuke, Marcus A, Weedon, Michael N, Hastie, Alex R, Cao, Han, Moon, Jennifer E, Kashin, Seva, Fuchsberger, Christian, Metspalu, Andres, Pato, Carlos N, Pato, Michele T, McCarthy, Mark I, Boehnke, Michael, Altshuler, David M, Frayling, Timothy M, Hirschhorn, Joel N, McCarroll, Steven A

“…Steven McCarroll, Joel Hirschhorn and colleagues identify eight common structural forms of the human amylase locus. They measured amylase gene copy number in…”
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A comprehensive family-based replication study of schizophrenia genes by Aberg, Karolina A, Liu, Youfang, Bukszár, Jozsef, McClay, Joseph L, Khachane, Amit N, Andreassen, Ole A, Blackwood, Douglas, Corvin, Aiden, Djurovic, Srdjan, Gurling, Hugh, Ophoff, Roel, Pato, Carlos N, Pato, Michele T, Riley, Brien, Webb, Todd, Kendler, Kenneth, O'Donovan, Mick, Craddock, Nick, Kirov, George, Owen, Mike, Rujescu, Dan, St Clair, David, Werge, Thomas, Hultman, Christina M, Delisi, Lynn E, Sullivan, Patrick, van den Oord, Edwin J

“…Schizophrenia (SCZ) is a devastating psychiatric condition. Identifying the specific genetic variants and pathways that increase susceptibility to SCZ is…”
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Prognostic value of polygenic risk scores for adults with psychosis by Landi, Isotta, Kaji, Deepak A., Cotter, Liam, Van Vleck, Tielman, Belbin, Gillian, Preuss, Michael, Loos, Ruth J. F., Kenny, Eimear, Glicksberg, Benjamin S., Beckmann, Noam D., O’Reilly, Paul, Schadt, Eric E., Achtyes, Eric D., Buckley, Peter F., Lehrer, Douglas, Malaspina, Dolores P., McCarroll, Steven A., Rapaport, Mark H., Fanous, Ayman H., Pato, Michele T., Pato, Carlos N., Bigdeli, Tim B., Nadkarni, Girish N., Charney, Alexander W.

“…Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level, and the aim is to use them as biomarkers of disease and poor…”
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Whole genome sequencing in psychiatric disorders: the WGSPD consortium by Sanders, Stephan J., Neale, Benjamin M., Huang, Hailiang, Werling, Donna M., An, Joon-Yong, Dong, Shan, Abecasis, Goncalo, Arguello, P. Alexander, Blangero, John, Boehnke, Michael, Daly, Mark J., Eggan, Kevin, Geschwind, Daniel H., Glahn, David C., Goldstein, David B., Gur, Raquel E., Handsaker, Robert E., McCarroll, Steven A., Ophoff, Roel A., Palotie, Aarno, Pato, Carlos N., Sabatti, Chiara, State, Matthew W., Willsey, A. Jeremy, Hyman, Steven E., Addington, Anjene M., Lehner, Thomas, Freimer, Nelson B.

“…As technology advances, whole genome sequencing (WGS) is likely to supersede other genotyping technologies. The rate of this change depends on its relative…”
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Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans by Bigdeli, Tim B, Fanous, Ayman H, Li, Yuli, Rajeevan, Nallakkandi, Sayward, Frederick, Genovese, Giulio, Gupta, Rishab, Radhakrishnan, Krishnan, Malhotra, Anil K, Sun, Ning, Lu, Qiongshi, Hu, Yiming, Li, Boyang, Chen, Quan, Mane, Shrikant, Miller, Perry, Cheung, Kei-Hoi, Gur, Raquel E, Greenwood, Tiffany A, Braff, David L, Achtyes, Eric D, Buckley, Peter F, Escamilla, Michael A, Lehrer, Douglas, Malaspina, Dolores P, McCarroll, Steven A, Rapaport, Mark H, Vawter, Marquis P, Pato, Michele T, Pato, Carlos N, Zhao, Hongyu, Kosten, Thomas R, Brophy, Mary, Pyarajan, Saiju, Shi, Yunling, O’Leary, Timothy J, Gleason, Theresa, Przygodzki, Ronald, Muralidhar, Sumitra, Gaziano, J Michael, Huang, Grant D, Concato, John, Siever, Larry J, Aslan, Mihaela, Harvey, Philip D

“…Abstract Background Schizophrenia (SCZ) and bipolar disorder (BIP) are debilitating neuropsychiatric disorders, collectively affecting 2% of the world’s…”
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