Search Results - "Patlolla, Jagan M R"

Triterpenoids for cancer prevention and treatment: current status and future prospects by Patlolla, Jagan M R, Rao, Chinthalapally V

“…Triterpenoids are ubiquitous in the plant kingdom. Recent evidences support the beneficial effects of naturallyoccurring triterpenoids against several types of…”
Get more information

Chemoprevention of Colon Cancer by DFMO, Sulindac, and NO-Sulindac Administered Individually or in Combinations in F344 Rats by Madka, Venkateshwar, Patlolla, Jagan M R, Venkatachalam, Karthikkumar, Zhang, Yuting, Pathuri, Gopal, Stratton, Nicole, Lightfoot, Stanley, Janakiram, Naveena B, Mohammed, Altaf, Rao, Chinthalapally V

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are promising colorectal cancer (CRC) chemopreventive drugs; however, to overcome NSAIDs' associated side…”
Get full text

Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids by Swamy, Malisetty V, Citineni, Bhargava, Patlolla, Jagan M.R, Mohammed, Altaf, Zhang, Yuting, Rao, Chinthalapally V

“…Pancreatic cancer BxPC-3 cells were exposed to curcumin, docosahexaenoic acid (DHA), or combinations of both and analyzed for proliferation and apoptosis…”
Get full text

Chemoprevention of Urothelial Cell Carcinoma Growth and Invasion by the Dual COX-LOX Inhibitor Licofelone in UPII-SV40T Transgenic Mice by MADKA, Venkateshwar, MOHAMMED, Altaf, RAO, Chinthalapally V, QIAN LI, YUTING ZHANG, PATLOLLA, Jagan M. R, BIDDICK, Laura, LIGHTFOOT, Stan, WU, Xue-Ru, STEELE, Vernon, KOPELOVICH, Levy

“…Epidemiologic and clinical data suggest that use of anti-inflammatory agents is associated with reduced risk for bladder cancer. We determined the…”
Get full text

Anti-carcinogenic properties of omeprazole against human colon cancer cells and azoxymethane-induced colonic aberrant crypt foci formation in rats by PATLOLLA, Jagan M. R, YUTING ZHANG, QIAN LI, STEELE, Vernon E, RAO, Chinthalapally V

“…Omeprazole is a proton pump inhibitor, a widely used drug to treat ulcers and gastroesophageal refluxdisease. We have evaluated colon cancer chemopreventive…”
Get full text

Inhibition of Azoxymethane-Induced Colorectal Cancer by CP-31398, a TP53 Modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats by RAO, Chinthalapally V, STEELE, Vernon E, SWAMY, Malisetty V, PATLOLLA, Jagan M. R, GURUSWAMY, Suresh, KOPELOVICH, Levy

“…Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53-modulating agent CP-31398 alone and…”
Get full text

Curcumin protects retinal cells from light-and oxidant stress-induced cell death by Mandal, Md Nawajes A., Patlolla, Jagan M.R., Zheng, Lixin, Agbaga, Martin-Paul, Tran, Julie-Thu A., Wicker, Lea, Kasus-Jacobi, Anne, Elliott, Michael H., Rao, Chinthalapally V., Anderson, Robert E.

“…Age-related macular degeneration (AMD) is a complex disease that has potential involvement of inflammatory and oxidative stress-related pathways in its…”
Get full text

Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats by RAO, Chinthalapally V, JOSEPH, Stancy, LI GAO, PATLOLLA, Jagan M. R, CHOI, Chang-In, KOPELOVICH, Levy, STEELE, Vernon E, RIGAS, Basil

“…Nitric oxide-donating aspirin (NO-ASA) represents class of promising chemopreventive NO-NSAIDs. NO-ASA combines the beneficial effects of ASA and the…”
Get full text

Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells by RAJU, Jayadev, PATLOLLA, Jagan M. R, SWAMY, Malisetty V, RAO, Chinthalapally V

“…Trigonella foenum graecum (fenugreek) is traditionally used to treat disorders such as diabetes, high cholesterol, wounds, inflammation, and gastrointestinal…”
Get full text

β-Escin Inhibits NNK-Induced Lung Adenocarcinoma and ALDH1A1 and RhoA/Rock Expression in A/J Mice and Growth of H460 Human Lung Cancer Cells by PATLOLLA, Jagan M. R, LI QIAN, BIDDICK, Laura, YUTING ZHANG, DESAI, Dhimant, AMIN, Shantu, LIGHTFOOT, Stan, RAO, Chinthalapally V

“…Lung cancer is the leading cause of cancer-related deaths. β-Escin, a triterpene saponin isolated from horse chestnut seeds, was tested for inhibition of lung…”
Get full text

Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice by PATLOLLA, JAGAN M.R, KOPELOVICH, LEVY, QIAN, LI, ZHANG, YUTING, KUMAR, GAURAV, MADKA, VENKATESHWAR, MOHAMMED, ALTAF, BIDDICK, LAURA, SADEGHI, MICHAEL, LIGHTFOOT, STAN, RAO, CHINTHALAPALLY V

“…In tobacco-associated lung cancers, the protein kinase B/mammalian target of rapamycin (Akt/mTOR) pathway frequently is activated by nicotine and its…”
Get full text

Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo by Madka, Venkateshwar, Mohammed, Altaf, Li, Qian, Zhang, Yuting, Biddick, Laura, Patlolla, Jagan M R, Lightfoot, Stan, Towner, Rheal A, Wu, Xue-Ru, Steele, Vernon E, Kopelovich, Levy, Rao, Chinthalapally V

“…Urothelial tumors, accompanied by mutations of the tumor suppressor protein TP53 and dysregulation of mTOR signaling, are frequently associated with aggressive…”
Get full text

Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets by Rao, Chinthalapally V, Reddy, Bandaru S, Steele, Vernon E, Wang, C-X, Liu, Xiaoping, Ouyang, Nengtai, Patlolla, Jagan M R, Simi, Barbara, Kopelovich, Levy, Rigas, Basil

“…Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising chemoprevention agents; unlike conventional NSAIDs, they seem free of…”
Get full text

Low doses of β‐carotene and lutein inhibit AOM‐induced rat colonic ACF formation but high doses augment ACF incidence by Raju, Jayadev, Swamy, Malisetty V., Cooma, Indranie, Patlolla, Jagan M.R., Pittman, Brian, Reddy, Bandaru S., Steele, Vernon E., Rao, Chinthalapally V.

“…Epidemiological studies suggest that carotenoids such as β‐carotene and lutein play an important role in reducing the risk for several cancers. However, in…”
Get full text

Overexpression of caveolin-1 in experimental colon adenocarcinomas and human colon cancer cell lines by Patlolla, Jagan M R, Swamy, Malisetty V, Raju, Jayadev, Rao, Chinthalapally V

“…Caveolin-1, -2, and -3 are the principal proteins of caveolae, the vesicular invaginations of the plasma membrane. Recent studies suggest that caveolins play…”
Get more information

Chemoprevention of familial adenomatous polyposis by low doses of atorvastatin and celecoxib given individually and in combination to APCMin mice by SWAMY, Malisetty V, PATLOLLA, Jagan M. R, STEELE, Vernon E, KOPELOVICH, Levy, REDDY, Bandaru S, RAO, Chinthalapally V

“…Preclinical and clinical studies have established evidence that cyclooxygenase-2 (COX-2) inhibitors and statins [hydroxy-3-methylglutaryl CoA reductase (HMGR)…”
Get full text

Anti-inflammatory and Anti-cancer Properties of β-Escin, a Triterpene Saponin by Patlolla, Jagan M. R., Rao, Chinthalapally V.

“…Horse chestnut seed extract is well known for its anti-edematous and anti-inflammatory medicinal properties. More recently, potential anti-carcinogenic…”
Get full text

Beta-escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21(waf1/cip1) in colon cancer cells by Patlolla, Jagan M R, Raju, Jayadev, Swamy, Malisetty V, Rao, Chinthalapally V

“…Extracts of Aesculus hippocastanum (horse chestnut) seed have been used in the treatment of chronic venous insufficiency, edema, and hemorrhoids. Most of the…”
Get full text

Prevention of familial adenomatous polyp development in APC min mice and azoxymethane-induced colon carcinogenesis in F344 Rats by ω-3 fatty acid rich perilla oil by Rao, Chinthalapally V, Patlolla, Jagan M R, Cooma, Indrani, Kawamori, Toshihiko, Steele, Vernon E

“…The present study explored the preventive effects of perilla oil, rich in α-linolenic acid, in rodent models of colon tumorigenesis. Six-week-old male F344…”
Get full text

Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment by Swamy, Malisetty V, Cooma, Indranie, Patlolla, Jagan M R, Simi, Barbara, Reddy, Bandaru S, Rao, Chinthalapally V

“…To develop efficient synergistic or additive combinations of chemopreventive and nutritional agents to reduce the risk of colon cancer, experiments were…”
Get full text