Search Results - "Patlak, J. B."

Two Heads of Myosin Are Better Than One for Generating Force and Motion by Tyska, M. J., Dupuis, D. E., Guilford, W. H., Patlak, J. B., Waller, G. S., Trybus, K. M., Warshaw, D. M., Lowey, S.

“…Several classes of the myosin superfamily are distinguished by their "double-headed" structure, where each head is a molecular motor capable of hydrolyzing ATP…”
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Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone by Nelson, M T, Patlak, J B, Worley, J F, Standen, N B

“…Resistance arteries exist in a maintained contracted state from which they can dilate or constrict depending on need. In many cases, these arteries constrict…”
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Measuring kinetics of complex single ion channel data using mean-variance histograms by Patlak, J.B.

“…The measurement of single ion channel kinetics is difficult when those channels exhibit subconductance events. When the kinetics are fast, and when the current…”
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Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay by Debold, Edward P, Schmitt, J P, Patlak, J B, Beck, S E, Moore, J R, Seidman, J G, Seidman, C, Warshaw, D M

“…Point mutations in cardiac myosin, the heart's molecular motor, produce distinct clinical phenotypes: hypertrophic (HCM) and dilated (DCM) cardiomyopathy. Do…”
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Ca2+ currents in cerebral artery smooth muscle cells of rat at physiological Ca2+ concentrations by Rubart, M, Patlak, J B, Nelson, M T

“…Single Ca2+ channel and whole cell currents were measured in smooth muscle cells dissociated from resistance-sized (100-microns diameter) rat cerebral…”
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Sodium channel subconductance levels measured with a new variance-mean analysis by PATLAK, J. B

“…The currents through single Na+ channels were recorded from dissociated cells of the flexor digitorum brevis muscle of the mouse. At 15 degrees C the prolonged…”
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Slow currents through single sodium channels of the adult rat heart by PATLAK, J. B, ORTIZ, M

“…The currents through single Na+ channels from the sarcolemma of ventricular cells dissociated from adult rat hearts were studied using the patch-clamp…”
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Cooperating to unlock the voltage-dependent K channel by Patlak, J B

“…Patlak comments on research by Ledwell and Aldrich regarding the secrets of the voltage-dependent potassium channel's gating mechanism…”
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Two modes of gating during late Na+ channel currents in frog sartorius muscle by PATLAK, J. B, ORTIZ, M

“…Na+ currents were measured during 0.4-s depolarizing pulses using the cell-attached variation of the patch-clamp technique. Patches on Cs-dialyzed segments of…”
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Single calcium channel currents of arterial smooth muscle at physiological calcium concentrations by Gollasch, M, Hescheler, J, Quayle, J M, Patlak, J B, Nelson, M T

“…Entry of Ca through voltage-dependent Ca channels is an important regulator of the function of smooth muscle, cardiac muscle, and neurons. Although Ca channels…”
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Carbachol modulates voltage sensitivity of calcium channels in bronchial smooth muscle of rats by Kamishima, T, Nelson, M T, Patlak, J B

“…The role of voltage-dependent Ca channels in carbachol (CCh)-induced contraction of rat bronchus was investigated. Membrane depolarization and BAY K 8644, a Ca…”
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Opentime heterogeneity during bursting of sodium channels in frog skeletal muscle by Patlak, J.B., Ortiz, M., Horn, R.

“…Single voltage-activated Na+ channel currents were obtained from membrane patches on internally dialyzed skeletal muscle segments of adult frogs. The high…”
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Smooth muscle and skeletal muscle myosins produce similar unitary forces and displacements in the laser trap by Guilford, W.H., Dupuis, D.E., Kennedy, G., Wu, J., Patlak, J.B., Warshaw, D.M.

“…Purified smooth muscle myosin in the in vitro motility assay propels actin filaments at 1/10 the velocity, yet produces 3–4 times more force than skeletal…”
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Single glutamate-activated channels in locust muscle by PATLAK, J. B, GRATION, K. A. F, USHERWOOD, P. N. R

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Kinetic diversity of Na+ channel bursts in frog skeletal muscle by PATLAK, J. B, ORTIZ, M

“…Individual Na+ channels of dissociated frog skeletal muscle cells at 10 degrees C fail to inactivate in 0.02% of depolarizing pulses, thus producing bursts of…”
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A Mutant Heterodimeric Myosin with One Inactive Head Generates Maximal Displacement by Kad, Neil M., Rovner, Arthur S., Fagnant, Patricia M., Joel, Peteranne B., Kennedy, Guy G., Patlak, Joseph B., Warshaw, David M., Trybus, Kathleen M.

“…Each of the heads of the motor protein myosin II is capable of supporting motion. A previous report showed that double-headed myosin generates twice the…”
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Analysis and Implications of Equivalent Uniform Approximations of Nonuniform Unitary Synaptic Systems by Uteshev, Vladimir V., Patlak, Joseph B., Pennefather, Peter S.

“…Real synaptic systems consist of a nonuniform population of synapses with a broad spectrum of probability and response distributions varying between synapses,…”
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Slip Sliding Away: Load-Dependence of Velocity Generated by Skeletal Muscle Myosin Molecules in the Laser Trap by Debold, Edward P., Patlak, Joseph B., Warshaw, David M.

“…Skeletal muscle’s ability to shorten and lengthen against a load is a fundamental property, presumably reflecting the inherent load-dependence of the myosin…”
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The ionic basis for the action potential in the flight muscle of the fly,Sarcophaga bullata by Patlak, Joseph B.

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Mutations, molecules, and myotonia by Patlak, J B

“…The sequence-function linkages developed in several studies advance the understanding of myotonia and of the inner workings of the Napositive channel. These…”
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