Search Results - "Patlak, Clifford S."

Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs by Stonestreet, Barbara S, Sadowska, Grazyna B, Hanumara, R Choudary, Petrache, Mihaela, Petersson, Katherine H, Patlak, Clifford S

“…We examined the effects of hyperglycemic hyperosmolality on blood-brain barrier (BBB) permeability during development. We hypothesized that the barrier becomes…”
Get full text

MRI and quantitative autoradiographic studies following bolus injections of unlabeled and 14C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants by Nagaraja, Tavarekere N., Ewing, James R., Karki, Kishor, Jacobs, Paul E., Divine, George W., Fenstermacher, Joseph D., Patlak, Clifford S., Knight, Robert A.

“…In previous studies on a rat model of transient cerebral ischemia, the blood and brain concentrations of gadolinium‐diethylenetriaminepentaacetic acid…”
Get full text

In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain by Nagaraja, Tavarekere N, Patel, Padma, Gorski, Martin, Gorevic, Peter D, Patlak, Clifford S, Fenstermacher, Joseph D

“…Putatively active drugs are often intraventricularly administered to gain direct access to brain and circumvent the blood-brain barrier. A few studies on the…”
Get full text

The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots by Nagaraja, Tavarekere N., Karki, Kishor, Ewing, James R., Divine, George W., Fenstermacher, Joseph D., Patlak, Clifford S., Knight, Robert A.

“…The hypothesis that the arterial input function (AIF) of gadolinium‐diethylenetriaminepentaacetic acid injected by intravenous bolus and measured by the change…”
Get full text

Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[ C]DTPA by Knight, Robert A, Karki, Kishor, Ewing, James R, Divine, George W, Fenstermacher, Joseph D, Patlak, Clifford S, Nagaraja, Tavarekere N

“…An intravenous step-down infusion procedure that maintained a constant gadolinium-diethylene-triaminepentaacetic acid (Gd-DTPA) blood concentration and…”
Get full text

MRI and quantitative autoradiographic studies following bolus injections of unlabeled and (14)C-labeled gadolinium-diethylenetriaminepentaacetic acid in a rat model of stroke yield similar distribution volumes and blood-to-brain influx rate constants by Nagaraja, Tavarekere N, Ewing, James R, Karki, Kishor, Jacobs, Paul E, Divine, George W, Fenstermacher, Joseph D, Patlak, Clifford S, Knight, Robert A

“…In previous studies on a rat model of transient cerebral ischemia, the blood and brain concentrations of gadolinium-diethylenetriaminepentaacetic acid…”
Get full text

Effects of acute hyperosmolality on blood-brain barrier function in ovine fetuses and lambs by Stonestreet, Barbara S, Sadowska, Grazyna B, Leeman, Joanne, Hanumara, R Choudary, Petersson, Katherine H, Patlak, Clifford S

“…We examined the effects of hyperosmolality on blood-brain barrier (BBB) permeability during development to test the vulnerability of the immature barrier to…”
Get more information

Experimental estimates of the constants relating signal change to contrast concentration for cerebral blood volume by T2 MRI by Newman, George C, Hospod, Frank E, Patlak, Clifford S, Fain, Sean E, Pulfer, Kari A, Cook, Thomas D, O'Sullivan, Finbarr

“…Estimates of cerebral blood volume (CBV) obtained from dynamic contrast T2* -weighted magnetic resonance imaging (MRI) tend to be significantly higher than…”
Get full text

Imaging triiodothyronine binding kinetics in rat brain: A model for studies in human subjects by Greenberg, Joel H., Reivich, Martin, Gordon, Janice T., Schoenhoff, Monika B., Patlak, Clifford S., Dratman, Mary B.

“…Many lines of evidence indicate a role for thyroid hormones in the expression of cognitive and affective disorders. These conditions constitute a large…”
Get full text

Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations by Patlak, C S, Blasberg, R G

“…The method of graphical analysis for the evaluation of sequential data (e.g., tissue and blood concentrations over time) in which the test substance is…”
Get more information

Cerebral blood volume measurements by rapid contrast infusion and T2-weighted echo planar MRI by TUDORICA, Alina, HAI FANG LI, HOSPOD, Frank, DELUCIA-DERANJA, Evan, WEI HUANG, PATLAK, Clifford S, NEWMAN, George C

“…Cerebral blood volume (CBV) provides information complementary to that of cerebral blood flow in cerebral ischemia, tumors, and other conditions. We have…”
Get full text

Regulation of brain water during acute hyperosmolality in ovine fetuses, lambs, and adults by Stonestreet, Barbara S, Oen-Hsiao, Joyce M, Petersson, Katherine H, Sadowska, Grazyna B, Patlak, Clifford S

“…1  Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905; and 2  Department of…”
Get full text

Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus by Stonestreet, B S, Petersson, K H, Sadowska, G B, Pettigrew, K D, Patlak, C S

“…Antenatal corticosteroid therapy reduces the incidence of intraventricular hemorrhage in premature infants. Enhanced microvascular integrity might provide…”
Get full text

Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults by Stonestreet, Barbara S, Petersson, Katherine H, Sadowska, Grazyna B, Patlak, Clifford S

“…1 Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Brown University Medical School, Providence, Rhode Island 02905; and 2 Department of…”
Get full text

Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs by Sysyn, G D, Petersson, K H, Patlak, C S, Sadowska, G B, Stonestreet, B S

“…We showed that antenatal corticosteroids reduced blood-brain barrier permeability in fetuses at 60 and 80%, but not 90% of gestation, and decreased brain water…”
Get more information

Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data by Patlak, C S, Blasberg, R G, Fenstermacher, J D

“…A theoretical model of blood-brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and…”
Get more information

Calcium Compartments in Brain by Newman, George C., Hospod, Frank E., Patlak, Clifford S., Trowbridge, Sean D., Wilke, Richard J., Fuhrmann, Mark, Jones, Keith W.

“…Excellent progress has been made toward understanding the physiology and pharmacology of specific calcium-related cellular processes of the brain, but few…”
Get full text

Effects of duration of positive-pressure ventilation on blood-brain barrier function in premature lambs by Stonestreet, Barbara S, McKnight, Amanda J, Sadowska, Grazyna, Petersson, Katherine H, Oen, Joyce M, Patlak, Clifford S

“…1  Brown University School of Medicine, Department of Pediatrics, Women and Infants' Hospital of Rhode Island, Providence, Rhode Island 02905; and 2…”
Get full text

Susceptibility changes following bolus injections by Albert, M S, Huang, W, Lee, J H, Patlak, C S, Springer, Jr, C S

“…The general mechanism of bulk magnetic susceptibility (BMS) induced MRI contrast following a bolus injection is elaborated. Combining radiolabeled tracer data…”
Get more information

A compartmental analysis of 24Na kinetics in rat cerebrum, sciatic nerve and cerebrospinal fluid by Levin, Victor, Patlak, Clifford S.

“…1. The kinetics of 24 Na exchange in rat cerebrospinal fluid, brain and sciatic nerve were studied during steady-state plasma isotope conditions. The entrance…”
Get full text