Search Results - "Patil, Kiran. R."

Bioaccumulation of therapeutic drugs by human gut bacteria by Klünemann, Martina, Andrejev, Sergej, Blasche, Sonja, Mateus, Andre, Phapale, Prasad, Devendran, Saravanan, Vappiani, Johanna, Simon, Bernd, Scott, Timothy A., Kafkia, Eleni, Konstantinidis, Dimitrios, Zirngibl, Katharina, Mastrorilli, Eleonora, Banzhaf, Manuel, Mackmull, Marie-Therese, Hövelmann, Felix, Nesme, Leo, Brochado, Ana Rita, Maier, Lisa, Bock, Thomas, Periwal, Vinita, Kumar, Manjeet, Kim, Yongkyu, Tramontano, Melanie, Schultz, Carsten, Beck, Martin, Hennig, Janosch, Zimmermann, Michael, Sévin, Daniel C., Cabreiro, Filipe, Savitski, Mikhail M., Bork, Peer, Typas, Athanasios, Patil, Kiran R.

“…Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and…”
Get full text

A pathogen-specific isotope tracing approach reveals metabolic activities and fluxes of intracellular Salmonella by Mitosch, Karin, Beyß, Martin, Phapale, Prasad, Drotleff, Bernhard, Nöh, Katharina, Alexandrov, Theodore, Patil, Kiran R, Typas, Athanasios

“…Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge…”
Get full text

Polarization of microbial communities between competitive and cooperative metabolism by Machado, Daniel, Maistrenko, Oleksandr M., Andrejev, Sergej, Kim, Yongkyu, Bork, Peer, Patil, Kaustubh R., Patil, Kiran R.

“…Resource competition and metabolic cross-feeding are among the main drivers of microbial community assembly. Yet the degree to which these two conflicting…”
Get full text

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition by Oatley, Morgan, Bölükbası, Özge Vargel, Svensson, Valentine, Shvartsman, Maya, Ganter, Kerstin, Zirngibl, Katharina, Pavlovich, Polina V., Milchevskaya, Vladislava, Foteva, Vladimira, Natarajan, Kedar N., Baying, Bianka, Benes, Vladimir, Patil, Kiran R., Teichmann, Sarah A., Lancrin, Christophe

“…The endothelial to haematopoietic transition (EHT) is the process whereby haemogenic endothelium differentiates into haematopoietic stem and progenitor cells…”
Get full text

Microbial interactions shape cheese flavour formation by Melkonian, Chrats, Zorrilla, Francisco, Kjærbølling, Inge, Blasche, Sonja, Machado, Daniel, Junge, Mette, Sørensen, Kim Ib, Andersen, Lene Tranberg, Patil, Kiran R., Zeidan, Ahmad A.

“…Cheese fermentation and flavour formation are the result of complex biochemical reactions driven by the activity of multiple microorganisms. Here, we studied…”
Get full text

Industrial systems biology of Saccharomyces cerevisiae enables novel succinic acid cell factory by Otero, José Manuel, Cimini, Donatella, Patil, Kiran R, Poulsen, Simon G, Olsson, Lisbeth, Nielsen, Jens

“…Saccharomyces cerevisiae is the most well characterized eukaryote, the preferred microbial cell factory for the largest industrial biotechnology product…”
Get full text

Highly parallelized laboratory evolution of wine yeasts for enhanced metabolic phenotypes by Ghiaci, Payam, Jouhten, Paula, Martyushenko, Nikolay, Roca-Mesa, Helena, Vázquez, Jennifer, Konstantinidis, Dimitrios, Stenberg, Simon, Andrejev, Sergej, Grkovska, Kristina, Mas, Albert, Beltran, Gemma, Almaas, Eivind, Patil, Kiran R, Warringer, Jonas

“…Adaptive Laboratory Evolution (ALE) of microorganisms can improve the efficiency of sustainable industrial processes important to the global economy. However,…”
Get full text

The Pioneer platform: A novel approach for selection of selective anti-cancer cytotoxic activity in bacteria through co-culturing with engineered human cells by Garland, Gavin D, Patil, Kiran R, Turner, Suzanne D, Willis, Anne E

“…Most of the small-molecule drugs approved for the treatment of cancer over the past 40 years are based on natural compounds. Bacteria provide an extensive…”
Get full text

High-throughput ultrastructure screening using electron microscopy and fluorescent barcoding by Bykov, Yury S, Cohen, Nir, Gabrielli, Natalia, Manenschijn, Hetty, Welsch, Sonja, Chlanda, Petr, Kukulski, Wanda, Patil, Kiran R, Schuldiner, Maya, Briggs, John A G

“…Genetic screens using high-throughput fluorescent microscopes have generated large datasets, contributing many cell biological insights. Such approaches cannot…”
Get full text

Metabolic memory underlying minimal residual disease in breast cancer by Radic Shechter, Ksenija, Kafkia, Eleni, Zirngibl, Katharina, Gawrzak, Sylwia, Alladin, Ashna, Machado, Daniel, Lüchtenborg, Christian, Sévin, Daniel C, Brügger, Britta, Patil, Kiran R, Jechlinger, Martin

“…Tumor relapse from treatment‐resistant cells (minimal residual disease, MRD) underlies most breast cancer‐related deaths. Yet, the molecular characteristics…”
Get full text

Glycolytic flux-signaling controls mouse embryo mesoderm development by Miyazawa, Hidenobu, Snaebjornsson, Marteinn T, Prior, Nicole, Kafkia, Eleni, Hammarén, Henrik M, Tsuchida-Straeten, Nobuko, Patil, Kiran R, Beck, Martin, Aulehla, Alexander

“…How cellular metabolic state impacts cellular programs is a fundamental, unresolved question. Here, we investigated how glycolytic flux impacts embryonic…”
Get full text

Reply to: Erroneous predictions of auxotrophies by CarveMe by Machado, Daniel, Patil, Kiran R.

Get full text

Predictive evolution of metabolic phenotypes using model‐designed environments by Jouhten, Paula, Konstantinidis, Dimitrios, Pereira, Filipa, Andrejev, Sergej, Grkovska, Kristina, Castillo, Sandra, Ghiachi, Payam, Beltran, Gemma, Almaas, Eivind, Mas, Albert, Warringer, Jonas, Gonzalez, Ramon, Morales, Pilar, Patil, Kiran R

“…Adaptive evolution under controlled laboratory conditions has been highly effective in selecting organisms with beneficial phenotypes such as stress tolerance…”
Get full text

OptFlux: an open-source software platform for in silico metabolic engineering by Rocha, Isabel, Maia, Paulo, Evangelista, Pedro, Vilaça, Paulo, Soares, Simão, Pinto, José P, Nielsen, Jens, Patil, Kiran R, Ferreira, Eugénio C, Rocha, Miguel

“…Over the last few years a number of methods have been proposed for the phenotype simulation of microorganisms under different environmental and genetic…”
Get full text

Model‐guided development of an evolutionarily stable yeast chassis by Pereira, Filipa, Lopes, Helder, Maia, Paulo, Meyer, Britta, Nocon, Justyna, Jouhten, Paula, Konstantinidis, Dimitrios, Kafkia, Eleni, Rocha, Miguel, Kötter, Peter, Rocha, Isabel, Patil, Kiran R

“…First‐principle metabolic modelling holds potential for designing microbial chassis that are resilient against phenotype reversal due to adaptive mutations…”
Get full text

Metabolic Response of Heterotrophic Arabidopsis Cells to Oxidative Stress by Baxter, Charles J, Redestig, Henning, Schauer, Nicolas, Repsilber, Dirk, Patil, Kiran R, Nielsen, Jens, Selbig, Joachim, Liu, Junli, Fernie, Alisdair R, Sweetlove, Lee J

“…To cope with oxidative stress, the metabolic network of plant cells must be reconfigured either to bypass damaged enzymes or to support adaptive responses. To…”
Get full text

Consistency across multi-omics layers in a drug-perturbed gut microbial community by Wuyts, Sander, Alves, Renato, Zimmermann-Kogadeeva, Maria, Nishijima, Suguru, Blasche, Sonja, Driessen, Marja, Geyer, Philipp E, Hercog, Rajna, Kartal, Ece, Maier, Lisa, Müller, Johannes B, Garcia Santamarina, Sarela, Schmidt, Thomas Sebastian B, Sevin, Daniel C, Telzerow, Anja, Treit, Peter V, Wenzel, Tobias, Typas, Athanasios, Patil, Kiran R, Mann, Matthias, Kuhn, Michael, Bork, Peer

“…Multi-omics analyses are used in microbiome studies to understand molecular changes in microbial communities exposed to different conditions. However, it is…”
Get full text

Finding Functional Differences Between Species in a Microbial Community: Case Studies in Wine Fermentation and Kefir Culture by Melkonian, Chrats, Gottstein, Willi, Blasche, Sonja, Kim, Yongkyu, Abel-Kistrup, Martin, Swiegers, Hentie, Saerens, Sofie, Edwards, Nathalia, Patil, Kiran R, Teusink, Bas, Molenaar, Douwe

“…Microbial life usually takes place in a community where individuals interact, by competition for nutrients, cross-feeding, inhibition by end-products, but also…”
Get full text

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota by Lindell, Anna E., Zimmermann-Kogadeeva, Maria, Patil, Kiran R.

“…The gut microbiota contributes to diverse aspects of host physiology, ranging from immunomodulation to drug metabolism. Changes in the gut microbiota…”
Get full text

Versatile Enzyme Expression and Characterization System for Aspergillus nidulans, with the Penicillium brevicompactum Polyketide Synthase Gene from the Mycophenolic Acid Gene Cluster as a Test Case by HANSEN, Bjarne G, SALOMONSEN, Bo, NIELSEN, Morten T, NIELSEN, Jakob B, HANSEN, Niels B, NIELSEN, Kristian F, REGUEIRA, Torsten B, NIELSEN, Jens, PATIL, Kiran R, MORTENSEN, Uffe H

“…Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text