Search Results - "Patidar, Praveen L."

XRN2 Links Transcription Termination to DNA Damage and Replication Stress by Morales, Julio C, Richard, Patricia, Patidar, Praveen L, Motea, Edward A, Dang, Tuyen T, Manley, James L, Boothman, David A

“…XRN2 is a 5'-3' exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving…”
Get full text

Fate, transformation and toxicological implications of environmental diclofenac: Role of mineralogy and solar flux by Ellepola, Nishanthi, Viera, Talysa, Patidar, Praveen L., Rubasinghege, Gayan

“…Diclofenac is an emerging surface water contaminant, yet the environmental impact of its degradation products remains elusive. The current study focuses on…”
Get full text

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors by Huang, Xiumei, Motea, Edward A., Moore, Zachary R., Yao, Jun, Dong, Ying, Chakrabarti, Gaurab, Kilgore, Jessica A., Silvers, Molly A., Patidar, Praveen L., Cholka, Agnieszka, Fattah, Farjana, Cha, Yoonjeong, Anderson, Glenda G., Kusko, Rebecca, Peyton, Michael, Yan, Jingsheng, Xie, Xian-Jin, Sarode, Venetia, Williams, Noelle S., Minna, John D., Beg, Muhammad, Gerber, David E., Bey, Erik A., Boothman, David A.

“…Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP) inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors…”
Get full text

The cohesin-like RecN protein stimulates RecA-mediated recombinational repair of DNA double-strand breaks by Uranga, Lee A., Reyes, Emigdio D., Patidar, Praveen L., Redman, Lindsay N., Lusetti, Shelley L.

“…RecN is a cohesin-like protein involved in DNA double-strand break repair in bacteria. The RecA recombinase functions to mediate repair via homologous DNA…”
Get full text

Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair by Morales, Julio C., Richard, Patricia, Rommel, Amy, Fattah, Farjana J., Motea, Edward A., Patidar, Praveen L., Xiao, Ling, Leskov, Konstantin, Wu, Shwu-Yuan, Hittelman, Walter N., Chiang, Cheng-Ming, Manley, James L., Boothman, David A.

“…Functions of Kub5-Hera (In Greek Mythology Hera controlled Artemis) (K-H), the human homolog of the yeast transcription termination factor Rtt103, remain…”
Get full text

Cystargolide-based amide and ester Pz analogues as proteasome inhibitors and anti-cancer agents by Viera, Carlos R, Stevens, Bradley T, Viera, Talysa, Zielinski, Cameron, Uranga, Lee A, Rogelj, Snezna, Patidar, Praveen L, Tello-Aburto, Rodolfo

“…A series of cystargolide-based β-lactone analogues containing nitrogen atoms at the Pz portion of the scaffold were prepared and evaluated as proteasome…”
Get full text

DNA damage induced by KP372-1 hyperactivates PARP1 and enhances lethality of pancreatic cancer cells with PARP inhibition by Viera, Talysa, Patidar, Praveen L.

“…The overall prognosis for pancreatic cancer remains dismal and potent chemotherapeutic agents that selectively target this cancer are critically needed…”
Get full text

A toxicological study on photo-degradation products of environmental ibuprofen: Ecological and human health implications by Ellepola, Nishanthi, Ogas, Talysa, Turner, Danielle N., Gurung, Rubi, Maldonado-Torres, Sabino, Tello-Aburto, Rodolfo, Patidar, Praveen L., Rogelj, Snezna, Piyasena, Menake E., Rubasinghege, Gayan

“…Increasing quantities of pharmaceutical waste in the environment have disrupted the balance of ecosystems, and may have subsequent effects on human health…”
Get full text

Molecular Basis of XRN2-Deficient Cancer Cell Sensitivity to Poly(ADP-ribose) Polymerase Inhibition by Viera, Talysa, Abfalterer, Quinn, Neal, Alyssa, Trujillo, Richard, Patidar, Praveen L

“…R-loops (RNA-DNA hybrids with displaced single-stranded DNA) have emerged as a potent source of DNA damage and genomic instability. The termination of…”
Get full text

XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition by Patidar, Praveen L., Viera, Talysa, Morales, Julio C., Singh, Naveen, Motea, Edward A., Khandelwal, Megha, Fattah, Farjana J.

“…Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2)…”
Get full text

The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair by Patidar, Praveen L, Motea, Edward A, Fattah, Farjana J, Zhou, Yunyun, Morales, Julio C, Xie, Yang, Garner, Harold R, Boothman, David A

“…Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double…”
Get full text

RecN Is a Cohesin-like Protein That Stimulates Intermolecular DNA Interactions in Vitro by Reyes, Emigdio D., Patidar, Praveen L., Uranga, Lee A., Bortoletto, Angelina S., Lusetti, Shelley L.

“…The bacterial RecN protein is involved in the recombinational repair of DNA double-stranded breaks, and recN mutants are sensitive to DNA-damaging agents…”
Get full text

Kub5-HeraRPRD1B deficiency promotes “BRCAness” and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers by Motea, Edward A., Fattah, Farjana J., Xiao, Ling, Girard, Luc, Rommel, Amy, Morales, Julio C., Patidar, Praveen L., Zhou, Yunyun, Porter, Andrew C., Xie, Yang, Minna, John D., Boothman, David A.

Get full text

Role of conserved sequence motifs in the function of the bacterial cohesin-like RECN protein in DNA repair by Patidar, Praveen L

“…DNA double strand breaks (DSBs) are one of the most deleterious types of DNA lesions because they might lead to cell death or gross chromosomal rearrangements…”
Get full text