Search Results - "Patiño, Bonell"
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P985: CLL‐1 IS AN ADOPTIVE IMMUNOTHERAPY TARGET IN JUVENILE MYELOMONOCYTIC LEUKEMIA
Published in HemaSphere (08-08-2023)Get full text
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Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma
Published in Cell chemical biology (18-08-2022)“…Proteasome inhibitor (PI) resistance remains a central challenge in multiple myeloma. To identify pathways mediating resistance, we first mapped…”
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Unraveling the surface proteomic profile of multiple myeloma to reveal new immunotherapeutic targets and markers of drug resistance
Published in Cell Stress (01-11-2022)“…The cell surface proteome ("surfaceome") serves as the interface between diseased cells and their local microenvironment. In cancer, this compartment is…”
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Frecuencia y características demográficas de pacientes con diagnóstico de trombosis de stents coronarios implantados en un hospital universitario entre enero de 2011 a diciembre de 2012
Published in Revista colombiana de cardiología (Bogotá, Colombia : 1989) (01-03-2016)“…Establecer la frecuencia y las características demográficas de pacientes con diagnóstico de trombosis de stent coronario atendidos en el Hospital Universitario…”
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CD38: From Positive to Negative Expression after Daratumumab Treatment
Published in Curēus (Palo Alto, CA) (10-04-2020)“…CD38 is a glycoprotein expressed at a low level in myeloid and lymphoid tissues. However, it is highly and homogeneously expressed in plasma cells (PC) in…”
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Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Published in Nature cancer (01-11-2023)“…Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis…”
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Niemann-Pick Disease: An Approach for Diagnosis in Adulthood
Published in Curēus (Palo Alto, CA) (28-05-2019)“…Niemann-Pick (NP) disease is a rare, autosomal recessive disorder characterized by visceromegaly and neurological alterations due to the excessive storage of…”
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Myelomastocytic Blast Cell Crisis in Resistant Tyrosine Kinase Inhibitor Chronic Myelogenous Leukemia: Case Report and Review of Literature
Published in Curēus (Palo Alto, CA) (21-05-2019)“…We present the clinical case of a 29-year-old male with a diagnosis of chronic myeloid leukemia (CML) in high-risk chronic phase since February 2010. He…”
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Overcoming proteasome inhibitor resistance in the immunotherapy era
Published in Trends in pharmacological sciences (Regular ed.) (01-08-2023)“…Proteasome inhibitors (PIs) are highly effective in multiple myeloma but all patients eventually develop resistance.The mechanisms governing PI resistance are…”
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Plasmablastic Lymphoma : 12 Year Experience from a Single Center in Colombia -South America
Published in Blood (05-11-2020)“…Introduction:Plasmablastic lymphoma (PBL) is a rare high-grade lymphoma, in which the cells of origin have overlapping features between B cells and plasma…”
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Primary Immunodeficiency-Associated Lymphoproliferative Disorders in Adults
Published in Clinical lymphoma, myeloma and leukemia (01-09-2019)Get full text
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Brentuximab Vedotin As Consolidation Therapy Post Hematopoietic Stem Cell Transplantation for Patients with Relapsed or Refractory Hodgkin Lymphoma: A Real World Analysis of the Colombian Experience
Published in Blood (13-11-2019)“…Introduction: High-dose chemotherapy followed by autologous stem-cell transplantation (auto-HCT) is standard of care for patients with relapsed or primary…”
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Severe Aplastic Anemia (SAA) in Colombia: Characteristics and Treatment in 6 Centers
Published in Blood (29-11-2018)“…Introduction Acquired severe aplastic anemia (SAA) is a low frequency hematologic disease associated with significant morbidity and mortality. The destruction…”
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CD38: From Positive to Negative Expression After Daratumumab Treatment. Case Report
Published in Clinical lymphoma, myeloma and leukemia (01-09-2018)Get full text
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The surfaceome of multiple myeloma cells suggests potential immunotherapeutic strategies and protein markers of drug resistance
Published in Nature communications (15-07-2022)“…The myeloma surface proteome (surfaceome) determines tumor interaction with the microenvironment and serves as an emerging arena for therapeutic development…”
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CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma
Published in Clinical cancer research (01-03-2024)“…Multiple myeloma is a plasma cell malignancy with an unmet clinical need for improved imaging methods and therapeutics. Recently, we identified CD46 as an…”
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Structural surfaceomics reveals an AML-specific conformation of integrin β 2 as a CAR T cellular therapy target
Published in Nature cancer (01-11-2023)“…Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the hypothesis…”
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FcεRIγ-negative NK cells persist in vivo and enhance efficacy of therapeutic monoclonal antibodies in multiple myeloma
Published in Blood advances (10-08-2021)“…Monoclonal antibodies (mAbs) are a central component of therapy for hematologic malignancies. Widely used mAb agents in multiple myeloma (MM) include…”
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Consenso colombiano para la prevención, el diagnóstico y el tratamiento de condiciones trombóticas en adultos con COVID-19: aplicando el Marco de la Evidencia a la Decisión (EtD) GRADE
Published in Revista colombiana de cardiología (Bogotá, Colombia : 1989) (01-09-2020)“…Resumen: Introducción: estudios recientes han reportado fenómenos trombóticos o coagulopatía en pacientes con COVID-19. Hay posiciones divergentes en cuanto a…”
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