Search Results - "Pathmasiri, Wimal"

The impact of early-life sub-therapeutic antibiotic treatment (STAT) on excessive weight is robust despite transfer of intestinal microbes by Schulfer, Anjelique F., Schluter, Jonas, Zhang, Yilong, Brown, Quincy, Pathmasiri, Wimal, McRitchie, Susan, Sumner, Susan, Li, Huilin, Xavier, Joao B., Blaser, Martin J.

“…The high-fat, high-calorie diets of westernized cultures contribute to the global obesity epidemic, and early life exposure to antibiotics may potentiate those…”
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Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice by Mazagova, Magdalena, Wang, Lirui, Anfora, Andrew T., Wissmueller, Max, Lesley, Scott A., Miyamoto, Yukiko, Eckmann, Lars, Dhungana, Suraj, Pathmasiri, Wimal, Sumner, Susan, Westwater, Caroline, Brenner, David A., Scmiabl, Bernd

“…Translocation of bacteria and their products across the intestinal barrier is common in patients with liver disease, and there is evidence that experimental…”
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Associations between the gut microbiome and metabolome in early life by Nguyen, Quang P, Karagas, Margaret R, Madan, Juliette C, Dade, Erika, Palys, Thomas J, Morrison, Hilary G, Pathmasiri, Wimal W, McRitche, Susan, Sumner, Susan J, Frost, H Robert, Hoen, Anne G

“…The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the…”
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Metabolomics Analysis of Hormone-Responsive and Triple-Negative Breast Cancer Cell Responses to Paclitaxel Identify Key Metabolic Differences by Stewart, Delisha A, Winnike, Jason H, McRitchie, Susan L, Clark, Robert F, Pathmasiri, Wimal W, Sumner, Susan J

“…To date, no targeted therapies are available to treat triple negative breast cancer (TNBC), while other breast cancer subtypes are responsive to current…”
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NMR and Metabolomics-A Roadmap for the Future by Wishart, David S, Cheng, Leo L, Copié, Valérie, Edison, Arthur S, Eghbalnia, Hamid R, Hoch, Jeffrey C, Gouveia, Goncalo J, Pathmasiri, Wimal, Powers, Robert, Schock, Tracey B, Sumner, Lloyd W, Uchimiya, Mario

“…Metabolomics investigates global metabolic alterations associated with chemical, biological, physiological, or pathological processes. These metabolic changes…”
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Maternal Serum Metabolomics in Mid-Pregnancy Identifies Lipid Pathways as a Key Link to Offspring Obesity in Early Childhood by Francis, Ellen C, Kechris, Katerina, Johnson, Randi K, Rawal, Shristi, Pathmasiri, Wimal, Rushing, Blake R, Du, Xiuxia, Jansson, Thomas, Dabelea, Dana, Sumner, Susan J, Perng, Wei

“…Maternal metabolism during pregnancy shapes offspring health via in utero programming. In the Healthy Start study, we identified five subgroups of pregnant…”
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Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice by Livanos, Alexandra E., Greiner, Thomas U., Vangay, Pajau, Pathmasiri, Wimal, Stewart, Delisha, McRitchie, Susan, Li, Huilin, Chung, Jennifer, Sohn, Jiho, Kim, Sara, Gao, Zhan, Barber, Cecily, Kim, Joanne, Ng, Sandy, Rogers, Arlin B., Sumner, Susan, Zhang, Xue-Song, Cadwell, Ken, Knights, Dan, Alekseyenko, Alexander, Bäckhed, Fredrik, Blaser, Martin J.

“…The early life microbiome plays important roles in host immunological and metabolic development. Because the incidence of type 1 diabetes (T1D) has been…”
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Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue by Sun, Xuezheng, Stewart, Delisha A, Sandhu, Rupninder, Kirk, Erin L, Pathmasiri, Wimal W, McRitchie, Susan L, Clark, Robert F, Troester, Melissa A, Sumner, Susan J

“…Breast carcinogenesis is a multistep process accompanied by widespread molecular and genomic alterations, both in tumor and in surrounding microenvironment. It…”
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Untargeted metabolomics reveal signatures of a healthy lifestyle by Pathmasiri, Wimal, Rushing, Blake R., McRitchie, Susan, Choudhari, Mansi, Du, Xiuxia, Smirnov, Alexsandr, Pelleigrini, Matteo, Thompson, Michael J., Sakaguchi, Camila A., Nieman, David C., Sumner, Susan J.

“…This cross-sectional study investigated differences in the plasma metabolome in two groups of adults that were of similar age but varied markedly in body…”
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Metabolomics Reveals New Mechanisms for Pathogenesis in Barth Syndrome and Introduces Novel Roles for Cardiolipin in Cellular Function by Sandlers, Yana, Mercier, Kelly, Pathmasiri, Wimal, Carlson, Jim, McRitchie, Susan, Sumner, Susan, Vernon, Hilary J

“…Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and…”
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Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics data by Barnes, Stephen, Benton, H. Paul, Casazza, Krista, Cooper, Sara J., Cui, Xiangqin, Du, Xiuxia, Engler, Jeffrey, Kabarowski, Janusz H., Li, Shuzhao, Pathmasiri, Wimal, Prasain, Jeevan K., Renfrow, Matthew B., Tiwari, Hemant K.

“…The study of metabolism has had a long history. Metabolomics, a systems biology discipline representing analysis of known and unknown pathways of metabolism,…”
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Metabolomics reveals biomarkers of opioid use disorder by Ghanbari, Reza, Li, Yuanyuan, Pathmasiri, Wimal, McRitchie, Susan, Etemadi, Arash, Pollock, Jonathan D., Poustchi, Hossein, Rahimi-Movaghar, Afarin, Amin-Esmaeili, Masoumeh, Roshandel, Gholamreza, Shayanrad, Amaneh, Abaei, Behrouz, Malekzadeh, Reza, Sumner, Susan C. J.

“…Opioid use disorder (OUD) is diagnosed using the qualitative criteria defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition…”
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Antibiotic-induced acceleration of type 1 diabetes alters maturation of innate intestinal immunity by Zhang, Xue-Song, Li, Jackie, Krautkramer, Kimberly A, Badri, Michelle, Battaglia, Thomas, Borbet, Timothy C, Koh, Hyunwook, Ng, Sandy, Sibley, Rachel A, Li, Yuanyuan, Pathmasiri, Wimal, Jindal, Shawn, Shields-Cutler, Robin R, Hillmann, Ben, Al-Ghalith, Gabriel A, Ruiz, Victoria E, Livanos, Alexandra, van 't Wout, Angélique B, Nagalingam, Nabeetha, Rogers, Arlin B, Sumner, Susan Jenkins, Knights, Dan, Denu, John M, Li, Huilin, Ruggles, Kelly V, Bonneau, Richard, Williamson, R Anthony, Rauch, Marcus, Blaser, Martin J

“…The early-life intestinal microbiota plays a key role in shaping host immune system development. We found that a single early-life antibiotic course (1PAT)…”
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A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties by Li, Yuan-Yuan, Stewart, Delisha A, Ye, Xiao-Min, Yin, Li-Hua, Pathmasiri, Wimal W, McRitchie, Susan L, Fennell, Timothy R, Cheung, Hon-Yeung, Sumner, Susan J

“…Due to the surge in type 2 diabetes mellitus (T2DM), treatments for chronic metabolic dysregulations with fewer side-effects are sought. Lycii Cortex (LyC), a…”
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Chemical exposures assessed via silicone wristbands and endogenous plasma metabolomics during pregnancy by Doherty, Brett T., McRitchie, Susan L., Pathmasiri, Wimal W., Stewart, Delisha A., Kirchner, David, Anderson, Kim A., Gui, Jiang, Madan, Juliette C., Hoen, Anne G., Sumner, Susan J., Karagas, Margaret R., Romano, Megan E.

“…Background Metabolomics is a promising method to investigate physiological effects of chemical exposures during pregnancy, with the potential to clarify…”
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Oral administration of TiO2 nanoparticles during early life impacts cardiac and neurobehavioral performance and metabolite profile in an age- and sex-related manner by Mortensen, Ninell P, Pathmasiri, Wimal, Snyder, Rodney W, Caffaro, Maria Moreno, Watson, Scott L, Patel, Purvi R, Beeravalli, Lakshmi, Prattipati, Sharmista, Aravamudhan, Shyam, Sumner, Susan J, Fennell, Timothy R

“…Abstract Background Nanoparticles (NPs) are increasingly incorporated in everyday products. To investigate the effects of early life exposure to orally…”
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A General Method for Targeted Quantitative Cross-Linking Mass Spectrometry by Chavez, Juan D, Eng, Jimmy K, Schweppe, Devin K, Cilia, Michelle, Rivera, Keith, Zhong, Xuefei, Wu, Xia, Allen, Terrence, Khurgel, Moshe, Kumar, Akhilesh, Lampropoulos, Athanasios, Larsson, Mårten, Maity, Shuvadeep, Morozov, Yaroslav, Pathmasiri, Wimal, Perez-Neut, Mathew, Pineyro-Ruiz, Coriness, Polina, Elizabeth, Post, Stephanie, Rider, Mark, Tokmina-Roszyk, Dorota, Tyson, Katherine, Vieira Parrine Sant'Ana, Debora, Bruce, James E

“…Chemical cross-linking mass spectrometry (XL-MS) provides protein structural information by identifying covalently linked proximal amino acid residues on…”
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Pretreatment with indomethacin results in increased heat stroke severity during recovery in a rodent model of heat stroke by Audet, Gerald N, Dineen, Shauna M, Stewart, Delisha A, Plamper, Mark L, Pathmasiri, Wimal W, McRitchie, Susan L, Sumner, Susan J, Leon, Lisa R

“…It has been suggested that medications can increase heat stroke (HS) susceptibility/severity. We investigated whether the nonsteroidal anti-inflammatory drug…”
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Metabolites as biomarkers of adverse reactions following vaccination: A pilot study using nuclear magnetic resonance metabolomics by McClenathan, Bruce M, Stewart, Delisha A, Spooner, Christina E, Pathmasiri, Wimal W, Burgess, Jason P, McRitchie, Susan L, Choi, Y. Sammy, Sumner, Susan C.J

“…Highlights • Metabolomics is the study of the small-molecule metabolite profile of an organism. • Metabolomics may help identify individuals predisposed to…”
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Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer by Fennell, Emily M J, Aponte-Collazo, Lucas J, Pathmasiri, Wimal, Rushing, Blake R, Barker, Natalie K, Partridge, Megan C, Li, Yuan-Yuan, White, Cody A, Greer, Yoshimi E, Herring, Laura E, Lipkowitz, Stanley, Sumner, Susan C J, Iwanowicz, Edwin J, Graves, Lee M

“…ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in and studies,…”
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