Search Results - "Pathania, Anup S."

Exosomal Long Non-coding RNAs: Emerging Players in the Tumor Microenvironment by Pathania, Anup S., Challagundla, Kishore B.

“…Recent advances in exosome biology have uncovered a significant role of exosomes in cancer and make them a determining factor in intercellular communication…”
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miR‐15a‐5p, miR‐15b‐5p, and miR‐16‐5p inhibit tumor progression by directly targeting MYCN in neuroblastoma by Chava, Srinivas, Reynolds, C. Patrick, Pathania, Anup S., Gorantla, Santhi, Poluektova, Larisa Y., Coulter, Don W., Gupta, Subash C., Pandey, Manoj K., Challagundla, Kishore B.

“…Neuroblastoma (NB) is the most common extracranial solid malignancy in children. Despite current aggressive treatment regimens, the prognosis for high‐risk NB…”
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The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma by Pathania, Anup S., Chava, Haritha, Chaturvedi, Nagendra K., Chava, Srinivas, Byrareddy, Siddappa N., Coulter, Don W., Challagundla, Kishore B.

“…Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature nerve cells, presenting significant treatment challenges due to…”
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SAP30, an oncogenic driver of progression, poor survival, and drug resistance in neuroblastoma by Prathipati, Philip, Pathania, Anup S., Chaturvedi, Nagendra K., Gupta, Subash C., Byrareddy, Siddappa N., Coulter, Don W., Challagundla, Kishore B.

“…Neuroblastoma is the most devastating extracranial solid malignancy in children. Despite an intense treatment regimen, the prognosis for high-risk…”
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The synthetic tryptanthrin analogue suppresses STAT3 signaling and induces caspase dependent apoptosis via ERK up regulation in human leukemia HL-60 cells by Pathania, Anup S, Kumar, Suresh, Guru, Santosh K, Bhushan, Shashi, Sharma, Parduman R, Aithagani, Sravan K, Singh, Parvinder P, Vishwakarma, Ram A, Kumar, Ajay, Malik, Fayaz

“…Tryptanthrin is a natural product which has been reported to have several medicinal properties. In this study, we tried to investigate the detailed molecular…”
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Interplay between cell cycle and autophagy induced by boswellic acid analog by Pathania, Anup S., Guru, Santosh K., Kumar, Suresh, Kumar, Ashok, Ahmad, Masroor, Bhushan, Shashi, Sharma, Parduman R., Mahajan, Priya, Shah, Bhahwal A., Sharma, Simmi, Nargotra, Amit, Vishwakarma, Ram, Korkaya, Hasan, Malik, Fayaz

“…In this study, we investigated the role of autophagy induced by boswellic acid analog BA145 on cell cycle progression in pancreatic cancer cells. BA145 induced…”
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miR-15a and miR-15b modulate natural killer and CD8+T-cell activation and anti-tumor immune response by targeting PD-L1 in neuroblastoma by Pathania, Anup S., Prathipati, Philip, Olwenyi, Omalla A., Chava, Srinivas, Smith, Oghenetejiri V., Gupta, Subash C., Chaturvedi, Nagendra K., Byrareddy, Siddappa N., Coulter, Don W., Challagundla, Kishore B.

“…Neuroblastoma (NB) is an enigmatic and deadliest pediatric cancer to treat. The major obstacles to the effective immunotherapy treatments in NB are defective…”
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PI3K‐α/mTOR/BRD4 inhibitor alone or in combination with other anti‐virals blocks replication of SARS‐CoV‐2 and its variants of concern including Delta and Omicron by Acharya, Arpan, Pathania, Anup S., Pandey, Kabita, Thurman, Michellie, Vann, Kendra R., Kutateladze, Tatiana G., Challagundala, Kishore B., Durden, Donald L., Byrareddy, Siddappa N.

“…[...]these vaccines/anti-virals safety, efficacy and durability remain unknown, especially for the individuals with comorbid conditions, and VOCs, such as…”
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Crosstalk between Noncoding RNAs and the Epigenetics Machinery in Pediatric Tumors and Their Microenvironment by Pathania, Anup S

“…According to the World Health Organization, every year, an estimated 400,000+ new cancer cases affect children under the age of 20 worldwide. Unlike adult…”
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New insights into exosome mediated tumor-immune escape: Clinical perspectives and therapeutic strategies by Pathania, Anup S., Prathipati, Philip, Challagundla, Kishore B.

“…Recent advances in extracellular vesicle biology have uncovered a substantial role in maintaining cell homeostasis in health and disease conditions by…”
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COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges by Pathania, Anup S, Prathipati, Philip, Abdul, Bakrudeen Aa, Chava, Srinivas, Katta, Santharam S, Gupta, Subash C, Gangula, Pandu R, Pandey, Manoj K, Durden, Donald L, Byrareddy, Siddappa N, Challagundla, Kishore B

“…The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the…”
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The role of exosomes and MYC in therapy resistance of acute myeloid leukemia: Challenges and opportunities by Mudgapalli, Nithya, Nallasamy, Palanisamy, Chava, Haritha, Chava, Srinivas, Pathania, Anup S., Gunda, Venugopal, Gorantla, Santhi, Pandey, Manoj K., Gupta, Subash C., Challagundla, Kishore B.

“…Acute myeloid leukemia (AML) is caused by abnormal production of white blood cells, red blood cells or platelets. The leukemia cells communicate with their…”
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Immune checkpoint molecules in neuroblastoma: A clinical perspective by Pathania, Anup S., Prathipati, Philip, Murakonda, Swati P., Murakonda, Ajay B., Srivastava, Ankit, Avadhesh, Byrareddy, Siddappa N., Coulter, Don W., Gupta, Subash C., Challagundla, Kishore B.

“…High-risk neuroblastoma (NB) is challenging to treat with 5-year long-term survival in patients remaining below 50% and low chances of survival after tumor…”
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GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis by Pathania, Anup S., Ren, Xiuhai, Mahdi, Min Y., Shackleford, Gregory M., Erdreich-Epstein, Anat

“…G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1) is most known as a regulator of G-protein coupled receptors. However, GRK2 also has other functions…”
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The crosstalk between non-coding RNAs and cell-cycle events: A new frontier in cancer therapy by Pathania, Anup S, Chava, Haritha, Balusu, Ramesh, Pasupulati, Anil K, Coulter, Don W, Challagundla, Kishore B

“…The cell cycle comprises sequential events during which a cell duplicates its genome and divides it into two daughter cells. This process is tightly regulated…”
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Correction: Chrysomycins A–C, antileukemic naphthocoumarins from Streptomyces sporoverrucosus by Jain, Shreyans K., Pathania, Anup S., Parshad, Rajinder, Raina, Chandji, Ali, Asif, Gupta, Ajai P., Kushwaha, Manoj, Aravinda, Subrayashastry, Bhushan, Shashi, Bharate, Sandip B., Vishwakarma, Ram A.

“…Correction for ‘Chrysomycins A–C, antileukemic naphthocoumarins from Streptomyces sporoverrucosus ’ by Shreyans K. Jain et al. , RSC Adv. , 2013, 3 ,…”
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Bioactive metabolites from an endophytic Cryptosporiopsis sp. inhabiting Clidemia hirta by Zilla, Mahesh K., Qadri, Masroor, Pathania, Anup S., Strobel, Gary A., Nalli, Yedukondalu, Kumar, Sunil, Guru, Santosh K., Bhushan, Shashi, Singh, Sanjay K., Vishwakarma, Ram A., Riyaz-Ul-Hassan, Syed, Ali, Asif

“…Cryptosporiposis sp. was isolated as an endophyte of Clidemia hirta as evidenced by ITS sequencing and microscopic examination of it fruiting structures. We…”
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Amino Acids Regulate Cisplatin Insensitivity in Neuroblastoma by Gunda, Venugopal, Pathania, Anup S, Chava, Srinivas, Prathipati, Philip, Chaturvedi, Nagendra K, Coulter, Don W, Pandey, Manoj K, Durden, Donald L, Challagundla, Kishore B

“…Neuroblastoma are pediatric, extracranial malignancies showing alarming survival prognosis outcomes due to their resilience to current aggressive treatment…”
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The emerging role of non-coding RNAs in the epigenetic regulation of pediatric cancers by Pathania, Anup S., Prathipati, Philip, Pandey, Manoj K., Byrareddy, Siddappa N., Coulter, Don W., Gupta, Subash C., Challagundla, Kishore B.

“…Epigenetics is a process that involves the regulation of gene expression without altering the sequence of DNA. Numerous studies have documented that epigenetic…”
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Semisynthesis of Mallotus B from Rottlerin: Evaluation of Cytotoxicity and Apoptosis-Inducing Activity by Jain, Shreyans K, Pathania, Anup S, Meena, Samdarshi, Sharma, Rajni, Sharma, Ashok, Singh, Baljinder, Gupta, Bishan D, Bhushan, Shashi, Bharate, Sandip B, Vishwakarma, Ram A

“…Mallotus B (2d) is a prenylated dimeric phloroglucinol compound isolated from Mallotus philippensis. There have been no reports on the synthesis or biological…”
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