Search Results - "Pathak, Sanjai K"

A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L by Dana, Dibyendu, Pathak, Sanjai K

“…Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an endopeptidase activity. Although its primary functions were…”
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Nek2 Kinase Signaling in Malaria, Bone, Immune and Kidney Disorders to Metastatic Cancers and Drug Resistance: Progress on Nek2 Inhibitor Development by Dana, Dibyendu, Das, Tuhin, Choi, Athena, Bhuiyan, Ashif I, Das, Tirtha K, Talele, Tanaji T, Pathak, Sanjai K

“…Cell cycle kinases represent an important component of the cell machinery that controls signal transduction involved in cell proliferation, growth, and…”
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Small molecule inhibitors of Nek2 kinase using a whole animal Nek2 overexpression model by Musayev, Rafael, Hauter, Lamia, Bhuiyan, Ashif I., Santha, Asha R., Dickson, Anna A., Finkelstein, Alan J., Talele, Tanaji T., Pathak, Sanjai K.

“…Nek2 kinase, a prominent member of the Never in Mitosis (NIMA) Related Kinases (Neks), is overexpressed in a wide variety of highly aggressive cancers. These…”
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Anti‐cancer Effects of Dual‐action Inhibitors of Nek2 and EGFR Kinases: Investigation of Synergy by Bhuiyan, Ashif I., Reghuvaran Santha, Asha, Das, Tuhin, Hernandez, Dianne, Musayev, Rafael, Ghoshal, Sarbani, Talele, Tanaji T., Pathak, Sanjai K.

“…While lung cancer is the leading cause of mortality among all cancer types for both men and women, breast cancer dominates cancer diagnosis among women…”
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Identification of a novel spirocyclic Nek2 inhibitor using high throughput virtual screening by Bhuiyan, Ashif I., Choi, Athena H., Ghoshal, Sarbani, Adiele, Ugochi A., Dana, Dibyendu, Choi, Jun Yong, Fath, Karl R., Talele, Tanaji T., Pathak, Sanjai K.

“…[Display omitted] NIMA Related Kinase 2 (Nek2) kinase is an attractive target for the development of therapeutic agents for several types of highly invasive…”
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GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice by Afrose, Leela, McDermott, Max V., Bhuiyan, Ashif I., Pathak, Sanjai K., Bobeck, Erin N.

“…A newly deorphanized G protein-coupled receptor, GPR171, is found to be highly expressed within the periaqueductal gray, a pain-modulating region in the brain…”
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Clickable, selective, and cell-permeable activity-based probe of human cathepsin B – Minimalistic approach for enhanced selectivity by Bhuiyan, Ashif I., Rathod, Pratikkumar, Ghoshal, Sarbani, Dana, Dibyendu, Das, Tuhin, Li, Guoshen, Dickson, Anna A., Rafi, Faiza, Subramaniam, Gopal S., Fath, Karl R., Paroly, Suneeta, Chang, Emmanuel J., Pathak, Sanjai K.

“…•A clickable and tagless activity-based probe (ABP) of human cathepsin B, KDA-1, is developed with a minimalistic design approach for enhanced selectivity.•The…”
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Cell penetrable, clickable and tagless activity-based probe of human cathepsin L by Dana, Dibyendu, Garcia, Jeremy, Bhuiyan, Ashif I., Rathod, Pratikkumar, Joo, Laura, Novoa, Daniel A., Paroly, Suneeta, Fath, Karl R., Chang, Emmanuel J., Pathak, Sanjai K.

“…Activity-based functional profiling of human cathepsin L activities from distinct proteomic origins. [Display omitted] •A highly sensitive and clickable…”
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GPR171 activation regulates morphine tolerance but not withdrawal in a test-dependent manner in mice by Afrose, Leela, McDermott, Max V., Bhuiyan, Ashif I., Pathak, Sanjai K., Bobeck, Erin N.

“…A newly deorphanized G protein-coupled receptor, GPR171, is found to be highly expressed within the periaqueductal gray, a pain-modulating region in the brain…”
Get full text