Search Results - "Pathak, Medha M"

Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing by Atcha, Hamza, Jairaman, Amit, Holt, Jesse R., Meli, Vijaykumar S., Nagalla, Raji R., Veerasubramanian, Praveen Krishna, Brumm, Kyle T., Lim, Huy E., Othy, Shivashankar, Cahalan, Michael D., Pathak, Medha M., Liu, Wendy F.

“…Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of…”
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Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells by Pathak, Medha M., Nourse, Jamison L., Tran, Truc, Hwe, Jennifer, Arulmoli, Janahan, Le, Dai Trang T., Bernardis, Elena, Flanagan, Lisa A., Tombola, Francesco

“…Significance Stem cells make lineage-choice decisions based on a combination of internal and external signals, including mechanical cues from the surrounding…”
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Membrane curvature governs the distribution of Piezo1 in live cells by Yang, Shilong, Miao, Xinwen, Arnold, Steven, Li, Boxuan, Ly, Alan T., Wang, Huan, Wang, Matthew, Guo, Xiangfu, Pathak, Medha M., Zhao, Wenting, Cox, Charles D., Shi, Zheng

“…Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian cells. The distribution of Piezo1 within a cell is essential for various…”
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Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing by Holt, Jesse R, Zeng, Wei-Zheng, Evans, Elizabeth L, Woo, Seung-Hyun, Ma, Shang, Abuwarda, Hamid, Loud, Meaghan, Patapoutian, Ardem, Pathak, Medha M

“…Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial barrier during wound healing. Mechanical cues are known to…”
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Voltage-Sensing Domain of Voltage-Gated Proton Channel Hv1 Shares Mechanism of Block with Pore Domains by Hong, Liang, Pathak, Medha M., Kim, Iris H., Ta, Dennis, Tombola, Francesco

“…Voltage-gated sodium, potassium, and calcium channels are made of a pore domain (PD) controlled by four voltage-sensing domains (VSDs). The PD contains the ion…”
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Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues by Atcha, Hamza, Meli, Vijaykumar S, Davis, Chase T, Brumm, Kyle T, Anis, Sara, Chin, Jessica, Jiang, Kevin, Pathak, Medha M, Liu, Wendy F

“…Macrophages are versatile cells of the innate immune system that perform diverse functions by responding to dynamic changes in their microenvironment. While…”
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PIEZO1 regulates leader cell formation and cellular coordination during collective keratinocyte migration by Chen, Jinghao, Holt, Jesse R, Evans, Elizabeth L, Lowengrub, John S, Pathak, Medha M

“…The collective migration of keratinocytes during wound healing requires both the generation and transmission of mechanical forces for individual cellular…”
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Ion channel mediated mechanotransduction in immune cells by Atcha, Hamza, Jairaman, Amit, Evans, Elizabeth L., Pathak, Medha M., Cahalan, Michael D., Liu, Wendy F.

“…The immune system performs critical functions to defend against invading pathogens and maintain tissue homeostasis. Immune cells reside within or are recruited…”
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Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers by Ellefsen, Kyle L., Holt, Jesse R., Chang, Alice C., Nourse, Jamison L., Arulmoli, Janahan, Mekhdjian, Armen H., Abuwarda, Hamid, Tombola, Francesco, Flanagan, Lisa A., Dunn, Alexander R., Parker, Ian, Pathak, Medha M.

“…Piezo channels transduce mechanical stimuli into electrical and chemical signals to powerfully influence development, tissue homeostasis, and regeneration…”
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Author Correction: Membrane curvature governs the distribution of Piezo1 in live cells by Yang, Shilong, Miao, Xinwen, Arnold, Steven, Li, Boxuan, Ly, Alan T., Wang, Huan, Wang, Matthew, Guo, Xiangfu, Pathak, Medha M., Zhao, Wenting, Cox, Charles D., Shi, Zheng

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Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner by Arulmoli, Janahan, Pathak, Medha M., McDonnell, Lisa P., Nourse, Jamison L., Tombola, Francesco, Earthman, James C., Flanagan, Lisa A.

“…Neural stem and progenitor cell (NSPC) fate is strongly influenced by mechanotransduction as modulation of substrate stiffness affects lineage choice. Other…”
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Mechanosensitive Ion Channel Piezo1 Regulates Diet-Induced Adipose Inflammation and Systemic Insulin Resistance by Zhao, Can, Sun, Qiushi, Tang, Lingyi, Cao, Yang, Nourse, Jamison L, Pathak, Medha M, Lu, Xiang, Yang, Qin

“…Adipocytes function as an energy buffer and undergo significant size and volume changes in response to nutritional cues. This adipocyte plasticity is important…”
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The twisted ion-permeation pathway of a resting voltage-sensing domain by Isacoff, Ehud Y, Pathak, Medha M, Tombola, Francesco, Gorostiza, Pau

“…Proteins containing voltage-sensing domains (VSDs) translate changes in membrane potential into changes in ion permeability or enzymatic activity. In channels,…”
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Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1 by Kim, Iris H, Hevezi, Peter, Varga, Csaba, Pathak, Medha M, Hong, Liang, Ta, Dennis, Tran, Chau T, Zlotnik, Albert, Soltesz, Ivan, Tombola, Francesco

“…The Hv1 channel and voltage-sensitive phosphatases share with voltage-gated sodium, potassium, and calcium channels the ability to detect changes in membrane…”
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How cells channel their stress: Interplay between Piezo1 and the cytoskeleton by Nourse, Jamison L., Pathak, Medha M.

“…•Ion channels are unique transducers of mechanical force.•The Piezo1 channel converts mechanical cues into electrical and biochemical signals.•Piezo1…”
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Mechanobiology of neural development by Abuwarda, Hamid, Pathak, Medha M.

“…As the brain develops, proliferating cells organize into structures, differentiate, migrate, extrude long processes, and connect with other cells. These…”
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Voltage-Sensing Domain of Voltage-Gated Proton Channel Hv1 Shares Mechanism of Block with Pore Domains by Hong, Liang, Pathak, Medha M., Kim, Iris H., Ta, Dennis, Tombola, Francesco

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PIEZO1 regulates leader cell formation and cellular coordination during collective cell migration: An integrative multiscale modeling and experimental study by Holt, Jesse, Chen, Jinghao, Evans, Elizabeth, Lowengrub, John, Pathak, Medha M.

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Closing In on the Resting State of the Shaker K + Channel by Pathak, Medha M., Yarov-Yarovoy, Vladimir, Agarwal, Gautam, Roux, Benoît, Barth, Patrick, Kohout, Susy, Tombola, Francesco, Isacoff, Ehud Y.

“…Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used…”
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Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering by Arulmoli, Janahan, Wright, Heather J., Phan, Duc T.T., Sheth, Urmi, Que, Richard A., Botten, Giovanni A., Keating, Mark, Botvinick, Elliot L., Pathak, Medha M., Zarembinski, Thomas I., Yanni, Daniel S., Razorenova, Olga V., Hughes, Christopher C.W., Flanagan, Lisa A.

“…[Display omitted] Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete…”
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