Search Results - "Pathak, D N"

DNA adduct formation by tamoxifen with rat and human liver microsomal activation systems by Pathak, D N, Bodell, W J

“…Using microsomal preparations from rat and human liver, we investigated the activation of the anti-estrogen compound tamoxifen (TMX) to form DNA adducts…”
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Tamoxifen metabolic activation : comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo by BHAGAVATULA MOORTHY, PADMAVATHI SRIRAM, PATHAK, D. N, BODELL, W. J, RANDERATH, K

“…One of our laboratories recently showed by 32P-postlabeling that administration of tamoxifen to mice induces two groups of hepatic DNA adducts comprising two…”
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Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen by Pathak, D N, Pongracz, K, Bodell, W J

“…Using rat liver microsomal preparations and peroxidase enzymes, we have investigated the formation of DNA adducts by the antiestrogen compound tamoxifen (TAM)…”
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Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: Comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen by Pathak, Deena N., Pongracz, Krisztina, Bodell, William J.

“…Daily intraperitoneal treatment of female Sprague-Dawley rats with either 5, 10 or 20 mg/kg tamoxifen (TAM) for 1 weeks increased the level of peroxidase…”
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Oxidation of eugenol to form DNA adducts and 8-hydroxy-2'-deoxyguanosine : Role of quinone methide derivative in DNA adduct formation by BODELL, W. J, QIUPING YE, PATHAK, D. N, PONGRACZ, K

“…We have investigated the activation of eugenol to form DNA adducts and oxidative base damage. Treatment of myeloperoxidase containing HL-60 cells with eugenol,…”
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Activation of the tamoxifen derivative metabolite E to form DNA adducts : comparison with the adducts formed by microsomal activation of tamoxifen by PONGRACZ, K, PATHAK, D. N, NAKAMURA, T, BURLINGAME, A. L, BODELL, W. J

“…(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)but-1-ene (metabolite E) has been detected in the plasma of patients treated with tamoxifen. We therefore investigated…”
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DNA adduct formation in the bone marrow of B6C3F1 mice treated with benzene by Pathak, D N, Lévay, G, Bodell, W J

“…We used P1-enhanced 32P-postlabeling to investigate DNA adduct formation in the bone marrow of B6C3F1 mice treated intraperitoneally with benzene (BZ). No…”
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Detection of DNA adducts in the white blood cells of B6C3F1 mice treated with benzene by LEVAY, G, PATHAK, D. N, BODELL, W. J

“…We have employed the P1-enhanced 32P-postlabeling procedure to detect the formation DNA of adducts in the white blood cells (WBC) of B6C3F1 mice treated by…”
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Effect of centrophenoxine on the antioxidative enzymes in various regions of the aging rat brain by Roy, D, Pathak, D N, Singh, R

“…This study investigated the effect (in vivo) of centrophenoxine (Helfergin) on the activity of antioxidant enzymes (glutathione peroxidase GSH-PER, glutathione…”
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An assessment of performance 'contract leprosy workers' in a National Leprosy Eradication Programme by Revankar, C R, Pai, V V, Ganapati, R, Pathak, D N

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Lipid peroxidation and glutathione peroxidase, glutathione reductase, superoxide dismutase, catalase, and glucose-6-phosphate dehydrogenase activities in FeCl3-induced epileptogenic foci in the rat brain by Singh, R, Pathak, D N

“…This study investigated the relationship between lipid peroxidation, subsequent activation of antioxidative enzymes, and development of iron-induced epilepsy…”
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Examination of microsomal cytochrome P450-catalyzed in vitro activation of o-phenylphenol to DNA binding metabolite(s) by 32P-postlabeling technique by Pathak, D N, Roy, D

“…It has been previously reported that the reactive metabolites phenylsemiquinone and phenylbenzoquinone are generated during microsomal cytochrome…”
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In vivo binding of diethylstilbestrol to nuclear proteins of kidneys of Syrian hamsters by Roy, Deodutta, Pathak, Deena Nath, Palangat, Murali

“…We demonstrate here that stilbene estrogen (diethylstilbestrol) is converted to nuclear protein binding metabolite(s) both in vitro and in vivo. In vitro…”
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Female Sterilization in Small Camp Settings in Rural India by Bhatt, Rohit V., Pachauri, Saroj, Pathak, Nisha D., Chauhan, Lalji

“…In an effort to provide female sterilization services in areas that lack modern surgical facilities and highly trained personnel, while avoiding the high…”
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Effects of chlorpromazine on the activities of antioxidant enzymes and lipid peroxidation in the various regions of aging rat brain by Roy, D, Pathak, D N, Singh, R

“…In this work, the effect of chronic intraperitoneal administration of chlorpromazine (5 and 10 mg/kg) on the antioxidant enzymes superoxide dismutase (SOD),…”
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Histone nuclear proteins are irreversibly modified by reactive metabolites of diethylstilbestrol by Roy, D, Pathak, D N

“…We demonstrate for the first time that diethylstilbestrol (DES), a synthetic estrogen, is converted by nuclei to histone-binding metabolite(s). Reaction of…”
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Capacity Building for collecting primary data through Crowdsourcing - An Example of Disaster affected Uttarakhand State (India) by Krishna Murthy, Y. V. N., Raju, P. L. N., Srivastav, S. K., Kumar, P., Mitra, D., Karnatak, H., Saran, S., Pandey, K., Oberai, K., Shiva Reddy, K., Gupta, K., Swamy, M., Deshmukh, A., Dadhwal, V. K., Bothale, V., Diwakar, P. G., Ravikumar, M. V., Leisely, A., Arulraj, M., Kumar, S., Rao, S. S., Singh Rawat, R., Pathak, D. M., Dutt, V., Negi, D., Singh, J., Shukla, K. K., Tomar, A., Ahmed, N., Singh, B., Singh, A. K., Shiva Kumar, R.

“…Uttarakhand State of India suffered a widespread devastation in June 2013 due to floods caused by excessive rain in the upper reaches of the Himalaya, glacial…”
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Nitric oxide: An autocrine regulator of Leydig cell steroidogenesis in the Asian catfish, Clarias batrachus by nee Pathak, Neelima Dubey, Lal, Bechan

“…Abstract Nitric oxide has been recognized as an important inter- and intra-cellular modulator of testicular steroidogenesis in higher vertebrates with…”
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A comparative study of the tubal ring applied via minilaparotomy and laparoscopy in postabortion cases by Bhatt, R V, Pachauri, S, Pathak, N D, John, E

“…Sterilization with tubal rings applied via minilaparotomy or laparoscopy was performed on 300 randomly selected postabortion subjects to evaluate the safety…”
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Paracrine role of macrophage produced-nitric oxide (NO) in Leydig cell steroidogenesis in a teleost, Clarias batrachus : Impact of gonadotropin, growth hormone and insulin on NO production by testicular macrophages by nee Pathak, Neelima Dubey, Lal, Bechan

“…Abstract The present in vitro study for the first time demonstrates the role of extragonadal hormones in regulation of NO production by testicular macrophages…”
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