Search Results - "Paterson, Ross"

Increased CSF neurogranin concentration is specific to Alzheimer disease by Wellington, Henrietta, Paterson, Ross W, Portelius, Erik, Törnqvist, Ulrika, Magdalinou, Nadia, Fox, Nick C, Blennow, Kaj, Schott, Jonathan M, Zetterberg, Henrik

“…OBJECTIVE:To assess the specificity of the dendritic protein neurogranin (Ng) in CSF from patients with a broad range of neurodegenerative diseases including a…”
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Epidemiological and cohort study finds no association between COVID-19 and Guillain-Barré syndrome by Keddie, Stephen, Pakpoor, Julia, Mousele, Christina, Pipis, Menelaos, Machado, Pedro M, Foster, Mark, Record, Christopher J, Keh, Ryan Y S, Fehmi, Janev, Paterson, Ross W, Bharambe, Viraj, Clayton, Lisa M, Allen, Claire, Price, Olivia, Wall, Jasmine, Kiss-Csenki, Annamaria, Rathnasabapathi, Devi Priya, Geraldes, Ruth, Yermakova, Tatyana, King-Robson, Joshua, Zosmer, Maya, Rajakulendran, Sanjeev, Sumaria, Sheetal, Farmer, Simon F, Nortley, Ross, Marshall, Charles R, Newman, Edward J, Nirmalananthan, Niranjanan, Kumar, Guru, Pinto, Ashwin A, Holt, James, Lavin, Tim M, Brennan, Kathryn M, Zandi, Michael S, Jayaseelan, Dipa L, Pritchard, Jane, Hadden, Robert D M, Manji, Hadi, Willison, Hugh J, Rinaldi, Simon, Carr, Aisling S, Lunn, Michael P

“…Reports of Guillain-Barré syndrome (GBS) have emerged during the Coronavirus disease 2019 (COVID-19) pandemic. This epidemiological and cohort study sought to…”
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Dementia wellbeing and COVID‐19: Review and expert consensus on current research and knowledge gaps by Liu, Kathy Y., Howard, Robert, Banerjee, Sube, Comas‐Herrera, Adelina, Goddard, Joanne, Knapp, Martin, Livingston, Gill, Manthorpe, Jill, O'Brien, John T., Paterson, Ross W., Robinson, Louise, Rossor, Martin, Rowe, James B., Sharp, David J., Sommerlad, Andrew, Suárez‐González, Aida, Burns, Alistair

“…Objectives In response to a commissioned research update on dementia during the COVID‐19 pandemic, a UK‐based working group, comprising dementia researchers…”
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Familial Alzheimer’s disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta by Arber, Charles, Toombs, Jamie, Lovejoy, Christopher, Ryan, Natalie S., Paterson, Ross W., Willumsen, Nanet, Gkanatsiou, Eleni, Portelius, Erik, Blennow, Kaj, Heslegrave, Amanda, Schott, Jonathan M., Hardy, John, Lashley, Tammaryn, Fox, Nick C., Zetterberg, Henrik, Wray, Selina

“…Familial Alzheimer’s disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by γ-secretase, increasing the proportion of longer amyloidogenic…”
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Mass spectrometry analysis of tau and amyloid‐beta in iPSC‐derived models of Alzheimer’s disease and dementia by Arber, Charles, Alatza, Argyro, Leckey, Claire A., Paterson, Ross W., Zetterberg, Henrik, Wray, Selina

“…Induced pluripotent stem cell (iPSC) technology enables the generation of human neurons in vitro, which contain the precise genome of the cell donor, therefore…”
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Cortical microstructure in young onset Alzheimer's disease using neurite orientation dispersion and density imaging by Parker, Thomas D., Slattery, Catherine F., Zhang, Jiaying, Nicholas, Jennifer M., Paterson, Ross W., Foulkes, Alexander J.M., Malone, Ian B., Thomas, David L., Modat, Marc, Cash, David M., Crutch, Sebastian J., Alexander, Daniel C., Ourselin, Sebastien, Fox, Nick C., Zhang, Hui, Schott, Jonathan M.

“…Alzheimer's disease (AD) is associated with extensive alterations in grey matter microstructure, but our ability to quantify this in vivo is limited. Neurite…”
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Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease by Heslegrave, Amanda, Heywood, Wendy, Paterson, Ross, Magdalinou, Nadia, Svensson, Johan, Johansson, Per, Öhrfelt, Annika, Blennow, Kaj, Hardy, John, Schott, Jonathan, Mills, Kevin, Zetterberg, Henrik

“…The discovery that heterozygous missense mutations in the gene encoding triggering receptor expressed on myeloid cells 2 (TREM2) are risk factors for…”
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CSF tau microtubule-binding region identifies pathological changes in primary tauopathies by Horie, Kanta, Barthélemy, Nicolas R., Spina, Salvatore, VandeVrede, Lawren, He, Yingxin, Paterson, Ross W., Wright, Brenton A., Day, Gregory S., Davis, Albert A., Karch, Celeste M., Seeley, William W., Perrin, Richard J., Koppisetti, Rama K., Shaikh, Faris, Lago, Argentina Lario, Heuer, Hilary W., Ghoshal, Nupur, Gabelle, Audrey, Miller, Bruce L., Boxer, Adam L., Bateman, Randall J., Sato, Chihiro

“…Despite recent advances in fluid biomarker research in Alzheimer’s disease (AD), there are no fluid biomarkers or imaging tracers with utility for diagnosis…”
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ApoE influences regional white matter axonal density loss in Alzheimer’s disease by Slattery, Catherine F., MA, MRCP, Zhang, Jiaying, MSc, Paterson, Ross W., MRCP, Foulkes, Alexander J.M., PhD, MRCP, Carton, Amelia, BSc, Macpherson, Kirsty, BA, Mancini, Laura, PhD, Thomas, David L., PhD, Modat, Marc, PhD, Toussaint, Nicolas, PhD, Cash, David M., PhD, Thornton, John S., PhD, Henley, Susie M.D., PhD, DClinPsych, Crutch, Sebastian J., PhD, Alexander, Daniel C., PhD, Ourselin, Sebastien, PhD, Fox, Nick C., FRCP, FMedSci, Zhang, Hui, PhD, Schott, Jonathan M., FRCP, MD

“…Abstract Mechanisms underlying phenotypic heterogeneity in young onset Alzheimer disease (YOAD) are poorly understood. We used diffusion tensor imaging (DTI)…”
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SILK studies — capturing the turnover of proteins linked to neurodegenerative diseases by Paterson, Ross W., Gabelle, Audrey, Lucey, Brendan P., Barthélemy, Nicolas R., Leckey, Claire A., Hirtz, Christophe, Lehmann, Sylvain, Sato, Chihiro, Patterson, Bruce W., West, Tim, Yarasheski, Kevin, Rohrer, Jonathan D., Wildburger, Norelle C., Schott, Jonathan M., Karch, Celeste M., Wray, Selina, Miller, Timothy M., Elbert, Donald L., Zetterberg, Henrik, Fox, Nick C., Bateman, Randall J.

“…Alzheimer disease (AD) is one of several neurodegenerative diseases characterized by dysregulation, misfolding and accumulation of specific proteins in the…”
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Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy by Banerjee, Gargi, Ambler, Gareth, Keshavan, Ashvini, Paterson, Ross W, Foiani, Martha S, Toombs, Jamie, Heslegrave, Amanda, Dickson, John C, Fraioli, Francesco, Groves, Ashley M, Lunn, Michael P, Fox, Nick C, Zetterberg, Henrik, Schott, Jonathan M, Werring, David J

“…There is limited data on cerebrospinal fluid (CSF) biomarkers in sporadic amyloid-β (Aβ) cerebral amyloid angiopathy (CAA). To determine the profile of…”
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Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy by Shakespeare, Timothy J, Kaski, Diego, Yong, Keir X X, Paterson, Ross W, Slattery, Catherine F, Ryan, Natalie S, Schott, Jonathan M, Crutch, Sebastian J

“…The clinico-neuroradiological syndrome posterior cortical atrophy is the cardinal 'visual dementia' and most common atypical Alzheimer's disease phenotype,…”
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Clinical relevance of positive voltage-gated potassium channel (VGKC)-complex antibodies: experience from a tertiary referral centre by Paterson, Ross W, Zandi, Michael S, Armstrong, Richard, Vincent, Angela, Schott, Jonathan M

“…Background Voltage-gated potassium channel (VGKC)-complex antibodies can be associated with a range of immunotherapy-responsive clinical presentations…”
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Strategic white matter hyperintensity locations for cognitive impairment: A multicenter lesion‐symptom mapping study in 3525 memory clinic patients by Coenen, Mirthe, Kuijf, Hugo J., Huenges Wajer, Irene M. C., Duering, Marco, Wolters, Frank J., Fletcher, Evan F., Maillard, Pauline M., Barkhof, Frederik, Barnes, Josephine, Benke, Thomas, Boomsma, Jooske M. F., Chen, Christopher P. L. H., Dal‐Bianco, Peter, Dewenter, Anna, Enzinger, Christian, Ewers, Michael, Exalto, Lieza G., Franzmeier, Nicolai, Groeneveld, Onno, Hilal, Saima, Hofer, Edith, Koek, Dineke L., Maier, Andrea B., McCreary, Cheryl R., Padilla, Catarina S., Papma, Janne M., Paterson, Ross W., Pijnenburg, Yolande A. L., Rubinski, Anna, Schmidt, Reinhold, Schott, Jonathan M., Slattery, Catherine F., Smith, Eric E., Steketee, Rebecca M. E., Sudre, Carole H., van den Berg, Esther, van der Flier, Wiesje M., Venketasubramanian, Narayanaswamy, Vernooij, Meike W., Xin, Xu, DeCarli, Charles, Biessels, Geert Jan, Biesbroek, J. Matthijs

“…Introduction Impact of white matter hyperintensities (WMH) on cognition likely depends on lesion location, but a comprehensive map of strategic locations is…”
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Imaging biomarkers in neurodegeneration: current and future practices by Young, Peter N E, Estarellas, Mar, Coomans, Emma, Srikrishna, Meera, Beaumont, Helen, Maass, Anne, Venkataraman, Ashwin V, Lissaman, Rikki, Jiménez, Daniel, Betts, Matthew J, McGlinchey, Eimear, Berron, David, O'Connor, Antoinette, Fox, Nick C, Pereira, Joana B, Jagust, William, Carter, Stephen F, Paterson, Ross W, Schöll, Michael

“…There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. The application of imaging…”
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Pain and temperature processing in dementia: a clinical and neuroanatomical analysis by Fletcher, Phillip D, Downey, Laura E, Golden, Hannah L, Clark, Camilla N, Slattery, Catherine F, Paterson, Ross W, Rohrer, Jonathan D, Schott, Jonathan M, Rossor, Martin N, Warren, Jason D

“…Symptoms suggesting altered processing of pain and temperature have been described in dementia diseases and may contribute importantly to clinical phenotypes,…”
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A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis by Norsworthy, Penny J., Thompson, Andrew G. B., Mok, Tze H., Guntoro, Fernando, Dabin, Luke C., Nihat, Akin, Paterson, Ross W., Schott, Jonathan M., Collinge, John, Mead, Simon, Viré, Emmanuelle A.

“…Sporadic Creutzfeldt-Jakob disease (sCJD) presents as a rapidly progressive dementia which is usually fatal within six months. No clinical blood tests are…”
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Cerebrospinal Fluid YKL-40 and Chitotriosidase Levels in Frontotemporal Dementia Vary by Clinical, Genetic and Pathological Subtype by Woollacott, Ione O C, Nicholas, Jennifer M, Heller, Carolin, Foiani, Martha S, Moore, Katrina M, Russell, Lucy L, Paterson, Ross W, Keshavan, Ashvini, Schott, Jonathan M, Warren, Jason D, Heslegrave, Amanda, Zetterberg, Henrik, Rohrer, Jonathan D

“…Chronic glial dysfunction may contribute to the pathogenesis of frontotemporal dementia (FTD). Cerebrospinal fluid (CSF) levels of glia-derived proteins YKL-40…”
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Clinical relevance of serum antibodies to extracellular N-methyl-d-aspartate receptor epitopes by Zandi, Michael S, Paterson, Ross W, Ellul, Mark A, Jacobson, Leslie, Al-Diwani, Adam, Jones, Joanne L, Cox, Amanda L, Lennox, Belinda, Stamelou, Maria, Bhatia, Kailash P, Schott, Jonathan M, Coles, Alasdair J, Kullmann, Dimitri M, Vincent, Angela

“…ObjectiveThere are now a large number of requests for N-methyl-d-aspartate receptor autoantibody (NMDAR-Ab) tests, and it is important to assess the clinical…”
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Automated quantitative MRI volumetry reports support diagnostic interpretation in dementia: a multi-rater, clinical accuracy study by Pemberton, Hugh G., Goodkin, Olivia, Prados, Ferran, Das, Ravi K., Vos, Sjoerd B., Moggridge, James, Coath, William, Gordon, Elizabeth, Barrett, Ryan, Schmitt, Anne, Whiteley-Jones, Hefina, Burd, Christian, Wattjes, Mike P., Haller, Sven, Vernooij, Meike W., Harper, Lorna, Fox, Nick C., Paterson, Ross W., Schott, Jonathan M., Bisdas, Sotirios, White, Mark, Ourselin, Sebastien, Thornton, John S., Yousry, Tarek A., Cardoso, M. Jorge, Barkhof, Frederik

“…Objectives We examined whether providing a quantitative report (QReport) of regional brain volumes improves radiologists’ accuracy and confidence in detecting…”
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