Search Results - "Paterson, Neil E."

Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone by Paterson, Neil E., Ricciardi, Jennifer, Wetzler, Caitlin, Hanania, Taleen

“…▶ PFC dopamine and norepinephrine are implicated in impulsivity deficits. ▶ Prolonged ITI induced high levels of impulsivity in rats in 5-CSRTT. ▶ Tolcapone…”
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Impulsive action and impulsive choice are mediated by distinct neuropharmacological substrates in rat by Paterson, Neil E., Wetzler, Caitlin, Hackett, Adrian, Hanania, Taleen

“…Impulsivity is a heterogeneous construct according to clinical and preclinical behavioural measures and there is some preliminary evidence indicating distinct…”
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The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats by Paterson, Neil E, Markou, Athina

“…The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse. The purpose of the present…”
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Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats by PATERSON, Neil E, FROESTL, Wolfgang, MARKOU, Athina

“…Acute administration of gamma-aminobutyric acid B (GABAB) receptor agonists decreased nicotine, cocaine, ethanol, and heroin self-administration. GABAB…”
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Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell by Paterson, Neil E., Balfour, David J., Markou, Athina

“…Bupropion, a dopamine reuptake inhibitor, is an effective therapy for smoking cessation, but the behavioral and neurochemical mechanisms mediating its…”
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Psychostimulant-like discriminative stimulus and locomotor sensitization properties of the wake-promoting agent modafinil in rodents by Paterson, Neil E., Fedolak, Allison, Olivier, Berend, Hanania, Taleen, Ghavami, Afshin, Caldarone, Barbara

“…The present studies assessed the potential abuse liability and likely mechanism(s) of action of the wake-promoting agent modafinil. Experiments assessed the…”
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Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats by O'Dell, Laura E, Chen, Scott A, Smith, Ron T, Specio, Sheila E, Balster, Robert L, Paterson, Neil E, Markou, Athina, Zorrilla, Eric P, Koob, George F

“…The present study characterized nicotine intake, circadian patterns of food and water intake, precipitated somatic signs of withdrawal, and extinction of…”
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Chemistry and Behavioral Studies Identify Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile by Zhang, Hankun, Tückmantel, Werner, Eaton, J. Brek, Yuen, Po-wai, Yu, Li-Fang, Bajjuri, Krishna Mohan, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Caldarone, Barbara, Paterson, Neil E, Lowe, David A, Brunner, Daniela, Lukas, Ronald J, Kozikowski, Alan P

“…Despite their discovery in the early 20th century and intensive study over the last 20 years, nicotinic acetylcholine receptors (nAChRs) are still far from…”
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Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats by PATERSON, Neil E, MYERS, Cynthia, MARKOU, Athina

“…The study of the effects of repeated amphetamine administration and withdrawal on brain reward function has relevance to both amphetamine dependence and…”
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Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: Recent preclinical and clinical insights by Paterson, Neil E.

“…Ongoing studies continue to explore the behavioural and pharmacological effects of bupropion in smoking cessation studies and animal models of nicotine…”
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The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat by PATERSON, Neil E, FROESTL, Wolfgang, MARKOU, Athina

“…Previous work has indicated a potential role for gamma-aminobutyric acid-B (GABA(B)) receptor agonists in treating drug addiction in humans. Specifically,…”
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Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats by Paterson, Neil E, Vlachou, Styliani, Guery, Sebastien, Kaupmann, Klemens, Froestl, Wolfgang, Markou, Athina

“…Acute administration of gamma-aminobutyric acid (GABA)-B receptor agonists decreases nicotine, cocaine, ethanol, and heroin self-administration and also…”
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Neural basis of smoking‐induced relief of craving and negative affect: Contribution of nicotine by Faulkner, Paul, Ghahremani, Dara G., Tyndale, Rachel F., Paterson, Neil E., Cox, Chelsea, Ginder, Nathaniel, Hellemann, Gerhard, London, Edythe D.

“…Smoking‐induced relief of craving and withdrawal promotes continued cigarette use. Understanding how relief is produced and the role of nicotine in this…”
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Translational research in addiction: Toward a framework for the development of novel therapeutics by Paterson, Neil E.

“…The development of novel substance use disorder (SUD) therapeutics is insufficient to meet the medical needs of a growing SUD patient population. The…”
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Pharmacological characterization of harmaline-induced tremor activity in mice by Paterson, Neil E., Malekiani, Sam A., Foreman, Mark M., Olivier, Berend, Hanania, Taleen

“…Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor…”
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The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice by PATERSON, Neil E, SEMENOVA, Svetlana, GASPARINI, Fabrizio, MARKOU, Athina

“…Nicotine increases glutamate release in the ventral tegmental area and the nucleus accumbens, and thus enhances dopamine neurotransmission in the mesolimbic…”
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N,N-Dimethyltryptamine-Induced Psychosis by Paterson, Neil E, Darby, W Connor, Sandhu, Preetpal S

“…N,N-dimethyltryptamine (DMT) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in humans. Recreational use of…”
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Increased motivation for self-administered cocaine after escalated cocaine intake by Paterson, Neil E, Markou, Athina

“…Escalation in cocaine self-administration is hypothesized to involve increased motivation to consume cocaine. The present study determined the effects of…”
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The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat by Paterson, Neil E., Semenova, Svetlana, Markou, Athina

“…Rationale Nicotine withdrawal is characterized by depression-like symptomatology that may be mediated by dysregulations in norepinephrine transmission. These…”
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Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380 by Caldarone, Barbara J., Wang, Daguang, Paterson, Neil E., Manzano, Michael, Fedolak, Allison, Cavino, Katie, Kwan, Mei, Hanania, Taleen, Chellappan, Sheela K., Kozikowski, Alan P., Olivier, Berend, Picciotto, Marina R., Ghavami, Afshin

“…Rationale Nicotinic acetylcholine receptor (nAChR) agonists, partial agonists, and antagonists have antidepressant-like effects in rodents and reduce symptoms…”
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