Search Results - "Paterson, Neil"

Antibody escape of SARS-CoV-2 Omicron BA.4 and BA.5 from vaccine and BA.1 serum by Tuekprakhon, Aekkachai, Huo, Jiandong, Nutalai, Rungtiwa, Dijokaite-Guraliuc, Aiste, Zhou, Daming, Ginn, Helen M., Selvaraj, Muneeswaran, Liu, Chang, Mentzer, Alexander J., Supasa, Piyada, Duyvesteyn, Helen M.E., Das, Raksha, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Conlon, Christopher, Deeks, Alexandra, Frater, John, Frending, Lisa, Gardiner, Siobhan, Jämsén, Anni, Jeffery, Katie, Malone, Tom, Phillips, Eloise, Rothwell, Lucy, Stafford, Lizzie, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…The Omicron lineage of SARS-CoV-2, first described in November 2021, spread rapidly to become globally dominant and has split into a number of sub-lineages…”
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De novo design of discrete, stable 310-helix peptide assemblies by Kumar, Prasun, Paterson, Neil G., Clayden, Jonathan, Woolfson, Derek N.

“…The α-helix is pre-eminent in structural biology 1 and widely exploited in protein folding 2 , design 3 and engineering 4 . Although other helical peptide…”
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Structural basis of outer membrane protein insertion by the BAM complex by Gu, Yinghong, Li, Huanyu, Dong, Haohao, Zeng, Yi, Zhang, Zhengyu, Paterson, Neil G., Stansfeld, Phillip J., Wang, Zhongshan, Zhang, Yizheng, Wang, Wenjian, Dong, Changjiang

“…All Gram-negative bacteria, mitochondria and chloroplasts have outer membrane proteins (OMPs) that perform many fundamental biological processes. The OMPs in…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG by Dong, Haohao, Zhang, Zhengyu, Tang, Xiaodi, Paterson, Neil G., Dong, Changjiang

“…The cell surface of most Gram-negative bacteria contains lipopolysaccharide that is essential for their viability and drug resistance. A 134-kDa protein…”
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Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient by Zhou, Daming, Duyvesteyn, Helen M. E., Chen, Cheng-Pin, Huang, Chung-Guei, Chen, Ting-Hua, Shih, Shin-Ru, Lin, Yi-Chun, Cheng, Chien-Yu, Cheng, Shu-Hsing, Huang, Yhu-Chering, Lin, Tzou-Yien, Ma, Che, Huo, Jiandong, Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N. M., Tan, Tiong Kit, Rijal, Pramila, Donat, Robert F., Godwin, Kerry, Buttigieg, Karen R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles W., Gilbert-Jaramillo, Javier, Knight, Michael L., James, William, Owens, Raymond J., Naismith, James H., Townsend, Alain R., Fry, Elizabeth E., Zhao, Yuguang, Ren, Jingshan, Stuart, David I., Huang, Kuan-Ying A.

“…The COVID-19 pandemic has had an unprecedented health and economic impact and there are currently no approved therapies. We have isolated an antibody, EY6A,…”
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Potent cross-reactive antibodies following Omicron breakthrough in vaccinees by Nutalai, Rungtiwa, Zhou, Daming, Tuekprakhon, Aekkachai, Ginn, Helen M., Supasa, Piyada, Liu, Chang, Huo, Jiandong, Mentzer, Alexander J., Duyvesteyn, Helen M.E., Dijokaite-Guraliuc, Aiste, Skelly, Donal, Ritter, Thomas G., Amini, Ali, Bibi, Sagida, Adele, Sandra, Johnson, Sile Ann, Constantinides, Bede, Webster, Hermione, Temperton, Nigel, Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Crook, Derrick, Pollard, Andrew J., Lambe, Teresa, Goulder, Philip, Paterson, Neil G., Williams, Mark A., Hall, David R., Mongkolsapaya, Juthathip, Fry, Elizabeth E., Dejnirattisai, Wanwisa, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Highly transmissible Omicron variants of SARS-CoV-2 currently dominate globally. Here, we compare neutralization of Omicron BA.1, BA.1.1, and BA.2. BA.2 RBD…”
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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum by Liu, Chang, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Wang, Beibei, Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Zhou, Daming, Mentzer, Alexander J., Zhao, Yuguang, Duyvesteyn, Helen M.E., López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Costa Clemens, Sue Ann, Gomes Naveca, Felipe, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Dold, Christina, Temperton, Nigel, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Malik, Tariq, Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Baillie, Vicky, Serafin, Natali, Ditse, Zanele, Da Silva, Kelly, Paterson, Neil G., Williams, Mark A., Hall, David R., Madhi, Shabir, Nunes, Marta C., Goulder, Philip, Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant…”
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Antibody evasion by the P.1 strain of SARS-CoV-2 by Dejnirattisai, Wanwisa, Zhou, Daming, Supasa, Piyada, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Nutalai, Rungtiwa, Wang, Beibei, López-Camacho, César, Slon-Campos, Jose, Walter, Thomas S., Skelly, Donal, Costa Clemens, Sue Ann, Naveca, Felipe Gomes, Nascimento, Valdinete, Nascimento, Fernanda, Fernandes da Costa, Cristiano, Resende, Paola Cristina, Pauvolid-Correa, Alex, Siqueira, Marilda M., Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah C., Carroll, Miles W., Klenerman, Paul, Barnes, Eleanor, Dunachie, Susanna J., Paterson, Neil G., Williams, Mark A., Hall, David R., Hulswit, Ruben J.G., Bowden, Thomas A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Terminating the SARS-CoV-2 pandemic relies upon pan-global vaccination. Current vaccines elicit neutralizing antibody responses to the virus spike derived from…”
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Structural basis for outer membrane lipopolysaccharide insertion by Dong, Haohao, Xiang, Quanju, Gu, Yinghong, Wang, Zhongshan, Paterson, Neil G., Stansfeld, Phillip J., He, Chuan, Zhang, Yizheng, Wang, Wenjian, Dong, Changjiang

“…Lipopolysaccharide (LPS) is essential for most Gram-negative bacteria and has crucial roles in protection of the bacteria from harsh environments and toxic…”
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Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera by Supasa, Piyada, Zhou, Daming, Dejnirattisai, Wanwisa, Liu, Chang, Mentzer, Alexander J., Ginn, Helen M., Zhao, Yuguang, Duyvesteyn, Helen M.E., Nutalai, Rungtiwa, Tuekprakhon, Aekkachai, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Hallis, Bassam, Coombes, Naomi, Bewley, Kevin R., Charlton, Sue, Walter, Thomas S., Barnes, Eleanor, Dunachie, Susanna J., Skelly, Donal, Lumley, Sheila F., Baker, Natalie, Shaik, Imam, Humphries, Holly E., Godwin, Kerry, Gent, Nick, Sienkiewicz, Alex, Dold, Christina, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Crook, Derrick, Lambe, Teresa, Clutterbuck, Elizabeth, Bibi, Sagida, Flaxman, Amy, Bittaye, Mustapha, Belij-Rammerstorfer, Sandra, Gilbert, Sarah, Hall, David R., Williams, Mark A., Paterson, Neil G., James, William, Carroll, Miles W., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…SARS-CoV-2 has caused over 2 million deaths in little over a year. Vaccines are being deployed at scale, aiming to generate responses against the virus spike…”
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Macrophage network dynamics depend on haptokinesis for optimal local surveillance by Paterson, Neil, Lämmermann, Tim

“…Macrophages are key immune cells with important roles for tissue surveillance in almost all mammalian organs. Cellular networks made up of many individual…”
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Ruthenium Polypyridyl Complex Bound to a Unimolecular Chair-Form G‑Quadruplex by McQuaid, Kane T, Takahashi, Shuntaro, Baumgaertner, Lena, Cardin, David J, Paterson, Neil G, Hall, James P, Sugimoto, Naoki, Cardin, Christine J

“…The DNA G-quadruplex is known for forming a range of topologies and for the observed lability of the assembly, consistent with its transient formation in live…”
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The antigenic anatomy of SARS-CoV-2 receptor binding domain by Dejnirattisai, Wanwisa, Zhou, Daming, Ginn, Helen M., Duyvesteyn, Helen M.E., Supasa, Piyada, Case, James Brett, Zhao, Yuguang, Walter, Thomas S., Mentzer, Alexander J., Liu, Chang, Wang, Beibei, Paesen, Guido C., Slon-Campos, Jose, López-Camacho, César, Kafai, Natasha M., Bailey, Adam L., Chen, Rita E., Ying, Baoling, Thompson, Craig, Bolton, Jai, Fyfe, Alex, Gupta, Sunetra, Tan, Tiong Kit, Gilbert-Jaramillo, Javier, James, William, Knight, Michael, Carroll, Miles W., Skelly, Donal, Dold, Christina, Peng, Yanchun, Levin, Robert, Dong, Tao, Pollard, Andrew J., Knight, Julian C., Klenerman, Paul, Temperton, Nigel, Hall, David R., Williams, Mark A., Paterson, Neil G., Bertram, Felicity K.R., Siebert, C. Alistair, Clare, Daniel K., Howe, Andrew, Radecke, Julika, Song, Yun, Townsend, Alain R., Huang, Kuan-Ying A., Fry, Elizabeth E., Mongkolsapaya, Juthathip, Diamond, Michael S., Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Antibodies are crucial to immune protection against SARS-CoV-2, with some in emergency use as therapeutics. Here, we identify 377 human monoclonal antibodies…”
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Improving pulse oximetry auditory displays: Anesthesiologists' perceptions by Paterson, Estrella, Sanderson, Penelope M., Loeb, Robert G., Paterson, Neil A. B.

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A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves by Kolter, Julia, Feuerstein, Reinhild, Zeis, Patrice, Hagemeyer, Nora, Paterson, Neil, d’Errico, Paolo, Baasch, Sebastian, Amann, Lukas, Masuda, Takahiro, Lösslein, Anne, Gharun, Kourosh, Meyer-Luehmann, Melanie, Waskow, Claudia, Franzke, Claus-Werner, Grün, Dominic, Lämmermann, Tim, Prinz, Marco, Henneke, Philipp

“…The skin comprises tissue macrophages as the most abundant resident immune cell type. Their diverse tasks including resistance against invading pathogens,…”
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Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B by Skaist Mehlman, Tamar, Biel, Justin T, Azeem, Syeda Maryam, Nelson, Elliot R, Hossain, Sakib, Dunnett, Louise, Paterson, Neil G, Douangamath, Alice, Talon, Romain, Axford, Danny, Orins, Helen, von Delft, Frank, Keedy, Daniel A

“…Much of our current understanding of how small-molecule ligands interact with proteins stems from X-ray crystal structures determined at cryogenic (cryo)…”
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Comparison of Standard and Enhanced Pulse Oximeter Auditory Displays of Oxygen Saturation: A Laboratory Study With Clinician and Nonclinician Participants by Paterson, Estrella, Sanderson, Penelope M., Brecknell, Birgit, Paterson, Neil A. B., Loeb, Robert G.

“…BACKGROUND:When engaged in visually demanding tasks, anesthesiologists depend on the auditory display of the pulse oximeter (PO) to provide information about…”
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The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
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Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili by Paterson, Neil G, Baker, Edward N

“…The surface of the pneumococcal cell is adorned with virulence factors including pili. The major pilin RrgB, which forms the pilus shaft on pathogenic…”
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