Search Results - "Paterson, Louise M"

Re-evaluating our focus in addiction: emotional dysregulation is a critical driver of relapse to drug use by Hand, Lexi J., Paterson, Louise M., Lingford-Hughes, Anne R.

“…Most addiction research has focused on reward- and impulsivity-related neurocircuitry. However, the impact of the withdrawal/negative affect stage in the…”
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Measuring endogenous 5-HT release by emission tomography: promises and pitfalls by Paterson, Louise M, Tyacke, Robin J, Nutt, David J, Knudsen, Gitte M

“…Molecular in vivo neuroimaging techniques can be used to measure regional changes in endogenous neurotransmitters, evoked by challenges that alter synaptic…”
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Sleep and its disorders in translational medicine by Paterson, Louise M, Nutt, David J, Wilson, Sue J

“…The study of sleep is a useful approach to studying the brain in psychiatric disorders and in investigating the effects of psychotropic drugs. Sleep physiology…”
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Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence by Vamvakopoulou, Ioanna A, Fonville, Leon, Hayes, Alexandra, McGonigle, John, Elliott, Rebecca, Ersche, Karen D, Flechais, Remy, Orban, Csaba, Murphy, Anna, Smith, Dana G, Suckling, John, Taylor, Eleanor M, Deakin, Bill, Robbins, Trevor W, Nutt, David J, Lingford-Hughes, Anne R, Paterson, Louise M

“…Negative affective states contribute to the chronic-relapsing nature of addiction. Mesolimbic dopamine D3 receptors are well placed to modulate emotion and are…”
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Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls by Turton, Samuel, Paterson, Louise M., Myers, James FM, Mick, Inge, Lan, Chen-Chia, McGonigle, John, Bowden-Jones, Henrietta, Clark, Luke, Nutt, David J., Lingford-Hughes, Anne R.

“…Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical and mental health consequences. AD and GD are…”
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Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures by Durant, Claire F, Paterson, Louise M, Turton, Sam, Wilson, Susan J, Myers, James F M, Muthukumaraswamy, Suresh, Venkataraman, Ashwin, Mick, Inge, Paterson, Susan, Jones, Tessa, Nahar, Limon K, Cordero, Rosa E, Nutt, David J, Lingford-Hughes, Anne

“…The role of GABA-B neurotransmission in addiction has recently received increased attention, with clinical trials indicating that baclofen, a GABA-B receptor…”
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Disturbances across whole brain networks during reward anticipation in an abstinent addiction population by Nestor, Liam J., Suckling, John, Ersche, Karen D., Murphy, Anna, McGonigle, John, Orban, Csaba, Paterson, Louise M., Reed, Laurence, Taylor, Eleanor, Flechais, Remy, Smith, Dana, Bullmore, Edward T., Elliott, Rebecca, Deakin, Bill, Rabiner, Ilan, Hughes, Anne-Lingford, Sahakian, Barbara J., Robbins, Trevor W., Nutt, David J.

“…Network based statistics (NBS) analyses detected a graph sub-network comprising 153 edges between 59 nodes of the connectome where the ADD group demonstrated…”
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A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers by PATERSON, Louise M, WILSON, Sue J, NUTT, David J, HUTSON, Peter H, IVARSSON, Magnus

“…Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate…”
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5-HT radioligands for human brain imaging with PET and SPECT by Paterson, Louise M., Kornum, Birgitte R., Nutt, David J., Pike, Victor W., Knudsen, Gitte M.

“…The serotonergic system plays a key modulatory role in the brain and is the target for many drug treatments for brain disorders either through reuptake…”
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Baclofen for the treatment of alcohol use disorder: the Cagliari Statement by Agabio, Roberta, Sinclair, Julia MA, Addolorato, Giovanni, Aubin, Henri-Jean, Beraha, Esther M, Caputo, Fabio, Chick, Jonathan D, de La Selle, Patrick, Franchitto, Nicolas, Garbutt, James C, Haber, Paul S, Heydtmann, Mathis, Jaury, Philippe, Lingford-Hughes, Anne R, Morley, Kirsten C, Müller, Christian A, Owens, Lynn, Pastor, Adam, Paterson, Louise M, Pélissier, Fanny, Rolland, Benjamin, Stafford, Amanda, Thompson, Andrew, van den Brink, Wim, de Beaurepaire, Renaud, Leggio, Lorenzo

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A dose‐finding design for dual‐agent trials with patient‐specific doses for one agent with application to an opiate detoxification trial by Mozgunov, Pavel, Cro, Suzie, Lingford‐Hughes, Anne, Paterson, Louise M., Jaki, Thomas

“…There is a growing interest in early phase dose‐finding clinical trials studying combinations of several treatments. While the majority of dose finding designs…”
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Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol‐dependent and polysubstance‐dependent individuals by Nestor, Liam J., Paterson, Louise M., Murphy, Anna, McGonigle, John, Orban, Csaba, Reed, Laurence, Taylor, Eleanor, Flechais, Remy, Smith, Dana, Bullmore, Edward T., Ersche, Karen D., Suckling, John, Elliott, Rebecca, Deakin, Bill, Rabiner, Ilan, Lingford Hughes, Anne, Sahakian, Barbara J., Robbins, Trevor W., Nutt, David J., Passetti, Filippo, Faravelli, Luca, Erritzoe, David, Mick, Inge, Kalk, Nicola, Waldman, Adam, Kuchibatla, Shankar, Boyapati, Venkataramana, Metastasio, Antonio, Faluyi, Yetunde, Fernandez‐Egea, Emilio, Abbott, Sanja, Voon, Valerie

“…Identifying key neural substrates in addiction disorders for targeted drug development remains a major challenge for clinical neuroscience. One emerging target…”
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NAPSAQ-1: National Patient Sleep Assessment Questionnaire in depression by Paterson, Louise M, Nutt, David J, Wilson, Sue J

“…Objectives. Sleep disturbance is a common feature of depression. Symptoms often persist after treatment of the depressive episode, representing a risk factor…”
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The Use of Baclofen as a Treatment for Alcohol Use Disorder: A Clinical Practice Perspective by de Beaurepaire, Renaud, Sinclair, Julia M A, Heydtmann, Mathis, Addolorato, Giovanni, Aubin, Henri-Jean, Beraha, Esther M, Caputo, Fabio, Chick, Jonathan D, de La Selle, Patrick, Franchitto, Nicolas, Garbutt, James C, Haber, Paul S, Jaury, Philippe, Lingford-Hughes, Anne R, Morley, Kirsten C, Müller, Christian A, Owens, Lynn, Pastor, Adam, Paterson, Louise M, Pélissier, Fanny, Rolland, Benjamin, Stafford, Amanda, Thompson, Andrew, van den Brink, Wim, Leggio, Lorenzo, Agabio, Roberta

“…Alcohol use disorder (AUD) is a brain disorder associated with high rates of mortality and morbidity worldwide. Baclofen, a selective gamma-aminobutyric acid-B…”
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Acute naltrexone does not remediate fronto‐striatal disturbances in alcoholic and alcoholic polysubstance‐dependent populations during a monetary incentive delay task by Nestor, Liam J, Murphy, Anna, McGonigle, John, Orban, Csaba, Reed, Laurence, Taylor, Eleanor, Flechais, Remy, Paterson, Louise M, Smith, Dana, Bullmore, Edward T, Ersche, Karen D, Suckling, John, Tait, Roger, Elliott, Rebecca, Deakin, Bill, Rabiner, Ilan, Lingford‐Hughes, Anne, Nutt, David J, Sahakian, Barbara, Robbins, Trevor W

“…There is a concerted research effort to investigate brain mechanisms underlying addiction processes that may predicate the development of new compounds for…”
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Naltrexone ameliorates functional network abnormalities in alcohol‐dependent individuals by Morris, Laurel S., Baek, Kwangyeol, Tait, Roger, Elliott, Rebecca, Ersche, Karen D., Flechais, Remy, McGonigle, John, Murphy, Anna, Nestor, Liam J., Orban, Csaba, Passetti, Filippo, Paterson, Louise M., Rabiner, Ilan, Reed, Laurence, Smith, Dana, Suckling, John, Taylor, Eleanor M., Bullmore, Edward T., Lingford‐Hughes, Anne R., Deakin, Bill, Nutt, David J., Sahakian, Barbara J., Robbins, Trevor W., Voon, Valerie

“…Naltrexone, an opioid receptor antagonist, is commonly used as a relapse prevention medication in alcohol and opiate addiction, but its efficacy and the…”
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Alterations in white matter microstructure in alcohol and alcohol‐polydrug dependence: Associations with lifetime alcohol and nicotine exposure by Agunbiade, Kofoworola, Fonville, Leon, McGonigle, John, Elliott, Rebecca, Ersche, Karen D., Flechais, Remy, Orban, Csaba, Murphy, Anna, Smith, Dana G., Suckling, John, Taylor, Eleanor M., Deakin, Bill, Robbins, Trevor W., Nutt, David J., Lingford‐Hughes, Anne R., Paterson, Louise M., Nutt, David, Lingford‐Hughes, Anne, Paterson, Louise, McGonigle, John, Flechais, Remy, Orban, Csaba, Deakin, Bill, Elliott, Rebecca, Murphy, Anna, Taylor, Eleanor, Robbins, Trevor, Ersche, Karen, Suckling, John, Smith, Dana, Reed, Laurence, Passetti, Filippo, Faravelli, Luca, Erritzoe, David, Mick, Inge, Kalk, Nicola, Waldman, Adam, Nestor, Liam, Kuchibatla, Shankar, Boyapati, Venkataramana, Metastasio, Antonio, Faluyi, Yetunde, Fernandez‐Egea, Emilio, Abbott, Sanja, Sahakian, Barbara, Voon, Valerie, Rabiner, Ilan

“…Evidence suggests that alcohol dependence (AD) is associated with microstructural deficits in white matter, but the relationship with lifetime alcohol exposure…”
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Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: A cross‐sectional study by Orban, Csaba, McGonigle, John, Flechais, Remy S.A., Paterson, Louise M., Elliott, Rebecca, Erritzoe, David, Ersche, Karen D., Murphy, Anna, Nestor, Liam J., Passetti, Filippo, Reed, Laurence J., Ribeiro, Andre S., Smith, Dana G., Suckling, John, Taylor, Eleanor M., Waldman, Adam D., Wing, Victoria C., Deakin, J.F. William, Robbins, Trevor W., Nutt, David J., Lingford‐Hughes, Anne R., Nutt, David, Lingford‐Hughes, Anne, Paterson, Louise, McGonigle, John, Flechais, Remy, Orban, Csaba, Deakin, Bill, Elliott, Rebecca, Murphy, Anna, Taylor, Eleanor, Robbins, Trevor, Ersche, Karen, Suckling, John, Smith, Dana, Reed, Laurence, Passetti, Filippo, Faravelli, Luca, Erritzoe, David, Mick, Inge, Kalk, Nicola, Waldman, Adam, Nestor, Liam, Kuchibatla, Shankar, Boyapati, Venkataramana, Metastasio, Antonio, Faluyi, Yetunde, Fernandez‐Egea, Emilio, Abbott, Sanja, Sahakian, Barbara, Voon, Valerie, Rabiner, Ilan

“…Animal models have shown that chronic alcohol exposure is associated with persistent neuroadaptations in amygdala synaptic function, whereas human studies have…”
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The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description by McGonigle, John, Murphy, Anna, Paterson, Louise M, Reed, Laurence J, Nestor, Liam, Nash, Jonathan, Elliott, Rebecca, Ersche, Karen D, Flechais, Remy SA, Newbould, Rexford, Orban, Csaba, Smith, Dana G, Taylor, Eleanor M, Waldman, Adam D, Robbins, Trevor W, Deakin, JF William, Nutt, David J, Lingford-Hughes, Anne R, Suckling, John

“…Objectives: We aimed to set up a robust multi-centre clinical fMRI and neuropsychological platform to investigate the neuropharmacology of brain processes…”
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The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description by Paterson, Louise M, Flechais, Remy SA, Murphy, Anna, Reed, Laurence J, Abbott, Sanja, Boyapati, Venkataramana, Elliott, Rebecca, Erritzoe, David, Ersche, Karen D, Faluyi, Yetunde, Faravelli, Luca, Fernandez-Egea, Emilio, Kalk, Nicola J, Kuchibatla, Shankar S, McGonigle, John, Metastasio, Antonio, Mick, Inge, Nestor, Liam, Orban, Csaba, Passetti, Filippo, Rabiner, Eugenii A, Smith, Dana G, Suckling, John, Tait, Roger, Taylor, Eleanor M, Waldman, Adam D, Robbins, Trevor W, Deakin, JF William, Nutt, David J, Lingford-Hughes, Anne R

“…Drug and alcohol dependence are global problems with substantial societal costs. There are few treatments for relapse prevention and therefore a pressing need…”
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