Search Results - "Paterson, I S"

Drying of open animal joints in vivo subsequently causes cartilage degeneration by Paterson, S I, Eltawil, N M, Simpson, A H R W, Amin, A K, Hall, A C

“…During open orthopaedic surgery, joints may be exposed to air, potentially leading to cartilage drying and chondrocyte death, however, the long-term effects of…”
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Pathophysiology of ischaemia reperfusion injury: central role of the neutrophil by Welbourn, C R, Goldman, G, Paterson, I S, Valeri, C R, Shepro, D, Hechtman, H B

“…Ischaemia is a common clinical event leading to local and remote injury. Evidence indicates that tissue damage is largely caused by activated neutrophils which…”
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Airflow accelerates bovine and human articular cartilage drying and chondrocyte death by Paterson, S.I, Amin, A.K, Hall, A.C

“…Summary Objective Exposure of articular cartilage to static air results in changes to the extracellular matrix (ECM) and stimulates chondrocyte death, which…”
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Postischemic renal injury is mediated by neutrophils and leukotrienes by Klausner, J M, Paterson, I S, Goldman, G, Kobzik, L, Rodzen, C, Lawrence, R, Valeri, C R, Shepro, D, Hechtman, H B

“…Neutrophils have been implicated as central mediators in myocardial and skeletal muscle ischemia-reperfusion injury. This study tests whether these cellular…”
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Managing the 2-week wait for breast patients by Singhal, Rishi, Marudanayagam, Ravi, Balasubramanian, B, Paterson, I S

“…Published data suggest that the 2-week wait system and triple assessment at one fast-track clinic visit is an out-dated method of capturing disease from a…”
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Ultrasonographic screening for abdominal aortic aneurysm in an urban community by Smith, F C, Grimshaw, G M, Paterson, I S, Shearman, C P, Hamer, J D

“…As part of the Birmingham Community Aneurysm Screening Project, 3500 men aged 65-75 years from 20 urban general practices were invited for aortic…”
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Neutrophil elastase and oxygen radicals: synergism in lung injury after hindlimb ischemia by Welbourn, C R, Goldman, G, Paterson, I S, Valeri, C R, Shepro, D, Hechtman, H B

“…Hindlimb ischemia and reperfusion lead to lung injury dependent on activated polymorphonuclear neutrophils (PMN) adherence. This study tests whether elastase…”
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Role for tumor necrosis factor as mediator of lung injury following lower torso ischemia by Welbourn, R, Goldman, G, O'Riordain, M, Lindsay, T F, Paterson, I S, Kobzik, L, Valeri, C R, Shepro, D, Hechtman, H B

“…Ischemia and reperfusion of the ischemic lower torso lead to a neutrophil- (PMN) dependent lung injury characterized by PMN sequestration and permeability…”
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Review of current practice to establish success after vasectomy (Br J Surg 2001; 88: 290-3) by Lee, C, Paterson, I S

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Noncardiogenic pulmonary edema after abdominal aortic aneurysm surgery by PATERSON, I. S, KLAUSNER, J. M, PUGATCH, R, ALLEN, P, MANNICK, J. A, SHEPRO, D, HECHTMAN, H. B

“…Limb ischemia in experimental animals leads to white blood cell (WBC) and thromboxane (Tx)A2 dependent pulmonary dysfunction. This study examines the pulmonary…”
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Limb ischemia-induced increase in permeability is mediated by leukocytes and leukotrienes by KLAUSNER, J. M, PATERSON, I. S, VALERI, C. R, SHEPRO, D, HECHTMAN, H. B

“…This study tests the role of white blood cells (WBC) and leukotrienes in mediating the increased microvascular permeability following ischemia and reperfusion…”
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Oxygen free radicals mediate ischemia-induced lung injury by Klausner, J M, Paterson, I S, Kobzik, L, Valeri, C R, Shepro, D, Hechtman, H B

“…Lower torso ischemia leads during reperfusion to leukocyte (white blood cell)-dependent lung injury. This study tests the intermediary role of oxygen free…”
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Role of Neutrophil Adherence Receptors (CD 18) in Lung Permeability Following Lower Torso Ischemia by Welbourn, Richard, Goldman, Gideon, Kobzik, Lester, Paterson, Ian S, Valeri, C R, Shepro, David, Hechtman, Herbert B

“…Ischemia and reperfusion of the lower torso lead to leukotriene- and neutrophil (PMN)-dependent lung injury characterized by lung PMN sequestration, increased…”
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Thromboxane A2 Mediates Increased Pulmonary Microvascular Permeability Following Limb Ischemia by Klausner, Joseph M, Paterson, Ian S, Goldman, Gideon, Kobzik, Lester, Valeri, C Robert, Shepro, David, Hechtman, Herbert B

“…Lower torso ischemia and reperfusion lead to respiratory dysfunction characterized by pulmonary hypertension and increased lung microvascular permeability…”
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Pulmonary edema after aneurysm surgery is modified by mannitol by PATERSON, I. S, KLAUSNER, J. M, GOLDMAN, G, PUGATCH, R, FEINGOLD, H, ALLEN, P, MANNICK, J. A, VALERI, C. R, SHEPRO, D, HECHTMAN, H. B

“…Abdominal aortic aneurysmectomy (AAA) results in thromboxane (Tx)A2 generation, a rise in mean pulmonary artery pressure (MPAP), leukopenia, and noncardiogenic…”
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Lower torso ischemia-induced lung injury is leukocyte dependent by Klausner, J M, Anner, H, Paterson, I S, Kobzik, L, Valeri, C R, Shepro, D, Hechtman, H B

“…Lower torso ischemia leads on reperfusion to sequestration of polymorphonuclear leukocytes (PMN) in the lungs and increased permeability. This study tests the…”
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Leukotrienes but not complement mediate limb ischemia-induced lung injury by KLAUSNER, J. M, PATERSON, I. S, KOBZIK, L, VALERI, C. R, SHEPRO, D, HECHTMAN, H. B

“…Reperfusion after limb ischemia leads to sequestration of polymorphonuclear leukocytes (PMN) in the lungs and to leukocyte- (WBC) and thromboxane- (Tx)…”
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Vasodilating prostaglandins attenuate ischemic renal injury only if thromboxane is inhibited by KLAUSNER, J. M, PATERSON, I. S, KOBZIK, L, RODZEN, C, VALERI, C. R, SHEPRO, D, HECHTMAN, H. B

“…Ischemia-induced renal injury is prevented by inhibition of thromboxane (Tx) synthesis. This protection was believed to be secondary to a high prostaglandin…”
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Reperfusion plasma contains a neutrophil activator by Paterson, I S, Smith, F C, Tsang, G M, Hamer, J D, Shearman, C P

“…Aortic aneurysm repair produces inflammatory mediators, neutrophil activation, and remote organ injury. Reperfusion plasma from these patients produces…”
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Interleukin-2-induced lung injury is mediated by oxygen free radicals by Klausner, J M, Paterson, I S, Goldman, G, Kobzik, L, Lelcuk, S, Skornick, Y, Eberlein, T, Valeri, C R, Shepro, D, Hechtman, H B

“…Interleukin-2 therapy leads to respiratory dysfunction caused by increased vascular permeability. This study examines the role of oxygen-derived free radicals…”
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