Search Results - "Paternoster, Veerle"
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Inactivation of the Schizophrenia-associated BRD1 gene in Brain Causes Failure-to-thrive, Seizure Susceptibility and Abnormal Histone H3 Acetylation and N-tail Clipping
Published in Molecular neurobiology (01-09-2021)“…Genetic studies have repeatedly shown that the Bromodomain containing 1 gene, BRD1 , is involved in determining mental health, and the importance of the BRD1…”
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Brain proteome changes in female Brd1+/− mice unmask dendritic spine pathology and show enrichment for schizophrenia risk
Published in Neurobiology of disease (01-04-2019)“…Genetic and molecular studies have implicated the Bromodomain containing 1 (BRD1) gene in the pathogenesis of schizophrenia and bipolar disorder. Accordingly,…”
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The psychiatric risk gene BRD1 modulates mitochondrial bioenergetics by transcriptional regulation
Published in Translational psychiatry (08-08-2022)“…Bromodomain containing 1 ( BRD1) encodes an epigenetic regulator that controls the expression of genetic networks linked to mental illness. BRD1 is essential…”
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Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice
Published in Translational psychiatry (17-07-2020)“…The schizophrenia-associated gene, BRD1 , encodes an epigenetic regulator in which chromatin interactome is enriched with genes implicated in mental health…”
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The importance of data structure in statistical analysis of dendritic spine morphology
Published in Journal of neuroscience methods (15-02-2018)“…•Data collection for dendritic spine morphology often results in multilevel data structure.•The need for implementation of data structure in statistical models…”
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The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice
Published in Biological psychiatry (1969) (01-07-2017)“…Abstract Background The schizophrenia-associated BRD1 gene encodes a transcriptional regulator whose comprehensive chromatin interactome is enriched with…”
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Brain volumetric alterations accompanied with loss of striatal medium-sized spiny neurons and cortical parvalbumin expressing interneurons in Brd1+/− mice
Published in Scientific reports (07-11-2018)“…Schizophrenia is a common and severe mental disorder arising from complex gene-environment interactions affecting brain development and functioning. While a…”
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Quantitative assessment of methyl-esterification and other side reactions in a standard propionylation protocol for detection of histone modifications
Published in Proteomics (Weinheim) (01-07-2016)“…Histone modifications play an important role in regulating chromatin stability and gene expression, but to date, investigating them remains challenging. In…”
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