Search Results - "Patera, Alexandra"

Crystal Structures of Substrate and Inhibitor Complexes with AmpC β-Lactamase:  Possible Implications for Substrate-Assisted Catalysis by Patera, Alexandra, Blaszczak, Larry C, Shoichet, Brian K

“…Group I β-lactamases are major resistance determinants to β-lactam antibiotics. Despite intense study, the identity of the catalytic base, the direction of…”
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Functional analyses of AmpC β-lactamase through differential stability by BEADLE, BETH M., McGOVERN, SUSAN L., PATERA, ALEXANDRA, SHOICHET, BRIAN K.

“…Despite decades of intense study, the complementarity of β-lactams for β-lactamases and penicillin binding proteins is poorly understood. For most of these…”
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The characterization of the structure of the active reactive site loop of alpha1-antitrypsin by multidimensional NMR methods by Patera, Alexandra Sacha

“…Serpins are a family of related proteins most of which act as specific inhibitors of serine proteinases. The details of the inhibitory mechanism of serpins are…”
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Redox-Dependent 1H NMR Spectral Features and Tertiary Structural Constraints on the C-Terminal Region of Putidaredoxin by Pochapsky, Thomas C, Ratnaswamy, Gayathri, Patera, Alexandra

“…Putidaredoxin (Pdx) is a 106-residue Fe2S2 ferredoxin which acts as the physiological reductant and effector of cytochrome P-450cam. Pdx has two accessible…”
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