Search Results - "Patel, Tirth K."

Neuronal activity regulates extracellular tau in vivo by Yamada, Kaoru, Holth, Jerrah K, Liao, Fan, Stewart, Floy R, Mahan, Thomas E, Jiang, Hong, Cirrito, John R, Patel, Tirth K, Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M

“…Tau is primarily a cytoplasmic protein that stabilizes microtubules. However, it is also found in the extracellular space of the brain at appreciable…”
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Dural lymphatics regulate clearance of extracellular tau from the CNS by Patel, Tirth K, Habimana-Griffin, LeMoyne, Gao, Xuefeng, Xu, Baogang, Achilefu, Samuel, Alitalo, Kari, McKee, Celia A, Sheehan, Patrick W, Musiek, Erik S, Xiong, Chengjie, Coble, Dean, Holtzman, David M

“…Alzheimer's disease is characterized by two main neuropathological hallmarks: extracellular plaques of amyloid-β (Aβ) protein and intracellular aggregates of…”
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Analysis of in vivo turnover of tau in a mouse model of tauopathy by Yamada, Kaoru, Patel, Tirth K, Hochgräfe, Katja, Mahan, Thomas E, Jiang, Hong, Stewart, Floy R, Mandelkow, Eva-Maria, Holtzman, David M

“…Intracellular accumulation of tau as neurofibrillary tangles (NFTs) is the hallmark of Alzheimer's disease (AD) as well as in other tauopathies. Tau is present…”
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An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology by Sheehan, Patrick W., Nadarajah, Collin J., Kanan, Michael F., Patterson, Jessica N., Novotny, Brenna, Lawrence, Jennifer H., King, Melvin W., Brase, Logan, Inman, Casey E., Yuede, Carla M., Lee, Jiyeon, Patel, Tirth K., Harari, Oscar, Benitez, Bruno A., Davis, Albert A., Musiek, Erik S.

“…The circadian clock protein BMAL1 modulates glial activation and amyloid-beta deposition in mice. However, the effects of BMAL1 on other aspects of…”
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A real dilemma by Patel, Tirth K, Geha, Rabih, Patel, Arpan, Benhammou, Jihane, Manesh, Reza, Patel, Satya

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Sleep in Alzheimer's Disease - Beyond Amyloid by Holth, Jerrah, Patel, Tirth, Holtzman, David M

“…Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of institutionalization. Like AD pathology, sleep abnormalities can appear years…”
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Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy by Yanamandra, Kiran, Patel, Tirth K, Jiang, Hong, Schindler, Suzanne, Ulrich, Jason D, Boxer, Adam L, Miller, Bruce L, Kerwin, Diana R, Gallardo, Gilbert, Stewart, Floy, Finn, Mary Beth, Cairns, Nigel J, Verghese, Philip B, Fogelman, Ilana, West, Tim, Braunstein, Joel, Robinson, Grace, Keyser, Jennifer, Roh, Joseph, Knapik, Stephanie S, Hu, Yan, Holtzman, David M

“…Tauopathies are a group of disorders in which the cytosolic protein tau aggregates and accumulates in cells within the brain, resulting in neurodegeneration. A…”
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Dual therapy for Aβ amyloidosis in AD: A successful one-two combo by Patel, Tirth K, Holtzman, David M

“…In this issue, Chiang et al. (https://doi.org/10.1084/jem.20171484) make a notable contribution to Alzheimer disease (AD) therapeutics in a thorough and…”
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Life of Tau: Oligomerization, CNS Extracellular Clearance and Role as Plasma Biomarker by Patel, Tirth K

“…The microtubule associated protein tau (MAPT, commonly referred to as tau) is an intrinsically disordered, highly soluble protein predominantly expressed in…”
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Neuronal activity regulates extracellular tau in vivo by Yamada, Kaoru, Holth, Jerrah K., Liao, Fan, Stewart, Floy R., Mahan, Thomas E., Jiang, Hong, Cirrito, John R., Patel, Tirth K., Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David

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Neuronal activity regulates extracellular tau in vivo by Yamada, Kaoru, Holth, Jerrah K., Liao, Fan, Stewart, Floy R., Mahan, Thomas E., Jiang, Hong, Cirrito, John R., Patel, Tirth K., Hochgräfe, Katja, Mandelkow, Eva-Maria, Holtzman, David M.

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