Search Results - "Patel, Tajhal"

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma by Tao, Ling, Mohammad, Mahmoud A., Milazzo, Giorgio, Moreno-Smith, Myrthala, Patel, Tajhal D., Zorman, Barry, Badachhape, Andrew, Hernandez, Blanca E., Wolf, Amber B., Zeng, Zihua, Foster, Jennifer H., Aloisi, Sara, Sumazin, Pavel, Zu, Youli, Hicks, John, Ghaghada, Ketan B., Putluri, Nagireddy, Perini, Giovanni, Coarfa, Cristian, Barbieri, Eveline

“…Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients;…”
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Identification of an early survival prognostic gene signature for localized osteosarcoma patients by Patel, Tajhal D., Grimm, Sandra L., Kanchi, Rupa S., Gandhi, Tanmay, Koirala, Amrit, Yustein, Jason T., Coarfa, Cristian

“…Osteosarcoma is the most prevalent bone tumor in pediatric patients. Neoadjuvant chemotherapy has improved osteosarcoma patient survival, however the 5-year…”
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LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination by Tsang, Susan V., Rainusso, Nino, Liu, Meng, Nomura, Motonari, Patel, Tajhal D., Nakahata, Kengo, Kim, Ha Ram, Huang, Shixia, Rajapakshe, Kimal, Coarfa, Cristian, Man, Tsz-Kwong, Rao, Pulivarthi H., Yustein, Jason T.

“…Osteosarcoma, the most common pediatric bone tumor, is an aggressive heterogeneous malignancy defined by complex chromosomal aberrations. Overall survival…”
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K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications by Nakahata, Kengo, Simons, Brian W, Pozzo, Enrico, Shuck, Ryan, Kurenbekova, Lyazat, Prudowsky, Zachary, Dholakia, Kshiti, Coarfa, Cristian, Patel, Tajhal D, Donehower, Lawrence A, Yustein, Jason T

“…Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of ∼65-70%. Thus, additional molecular…”
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p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma by Qasim, Shawki L., Sierra, Laura, Shuck, Ryan, Kurenbekova, Lyazat, Patel, Tajhal D., Rajapakshe, Kimal, Wulff, Jade, Nakahata, Kengo, Kim, Ha Ram, Landesman, Yosef, Unger, T. J., Coarfa, Cristian, Yustein, Jason T.

“…Ewing sarcoma (ES) is the second most common bone tumor in children and young adults. Unfortunately, there have been minimal recent advancements in improving…”
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MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma by Nirala, Bikesh K, Patel, Tajhal D, Kurenbekova, Lyazat, Shuck, Ryan, Dasgupta, Atreyi, Rainusso, Nino, Coarfa, Cristian, Yustein, Jason T

“…Osteosarcoma (OS) is the most common primary bone tumor of childhood. Approximately 20%-30% of OSs carry amplification of chromosome 8q24, which harbors the…”
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SOD1 is a synthetic-lethal target in PPM1D -mutant leukemia cells by Zhang, Linda, Hsu, Joanne I, Braekeleer, Etienne D, Chen, Chun-Wei, Patel, Tajhal D, Martell, Alejandra G, Guzman, Anna G, Wohlan, Katharina, Waldvogel, Sarah M, Uryu, Hidetaka, Tovy, Ayala, Callen, Elsa, Murdaugh, Rebecca L, Richard, Rosemary, Jansen, Sandra, Vissers, Lisenka, de Vries, Bert B A, Nussenzweig, Andre, Huang, Shixia, Coarfa, Cristian, Anastas, Jamie, Takahashi, Koichi, Vassiliou, George, Goodell, Margaret A

“…The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg /Mn…”
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Modeling Ewing Sarcoma Lung Metastasis by Dasgupta, Atreyi, Kurenbekova, Lyazat, Patel, Tajhal D, Rajapakshe, Kimal, Ghosal, Gargi, Nirala, Bikesh, Coarfa, Cristian, Yustein, Jason

“…Ewing Sarcoma (EwS) is the second most common malignant bone tumor in adolescents and young adults. The single-most powerful predictor of outcome in EwS is…”
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Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer by Thaiparambil, Jose, Dong, Jianrong, Grimm, Sandra L., Perera, Dimuthu, Ambati, Chandra Shekar R., Putluri, Vasanta, Robertson, Matthew J., Patel, Tajhal D., Mistretta, Brandon, Gunaratne, Preethi H., Kim, Min P., Yustein, Jason T., Putluri, Nagireddy, Coarfa, Cristian, El‐Zein, Randa

“…Background Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma…”
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CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming by Tao, Ling, Moreno‐Smith, Myrthala, Ibarra‐García‐Padilla, Rodrigo, Milazzo, Giorgio, Drolet, Nathan A., Hernandez, Blanca E., Oh, Young S., Patel, Ivanshi, Kim, Jean J., Zorman, Barry, Patel, Tajhal, Kamal, Abu Hena Mostafa, Zhao, Yanling, Hicks, John, Vasudevan, Sanjeev A., Putluri, Nagireddy, Coarfa, Cristian, Sumazin, Pavel, Perini, Giovanni, Parchem, Ronald J., Uribe, Rosa A., Barbieri, Eveline

“…Neuroblastoma (NB) arises from oncogenic disruption of neural crest (NC) differentiation. Treatment with retinoic acid (RA) to induce differentiation has…”
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Abstract 405: The role of GALNT14 in chemoresistant and metastatic osteosarcoma by Prudowsky, Zachary D., Patel, Tajhal, Rajapakshe, Kimal, Coarfa, Christian, Shuck, Ryan, Rainusso, Nino, Yustein, Jason

“…Introduction: Osteosarcoma is the most common bone tumor in children and adolescents. Many patients have disease progression through standard chemotherapy…”
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Abstract 6147: Myc-driven osteosarcoma murine model for dissecting the molecular genetics and novel therapeutic strategies for OS by Nirala, Bikesh Kumar, Lyazat, Kurenbekova, Patel, Tajhal, Shuck, Ryan Lane, Kimal, Rajapakshe, Yustein, Jason T.

“…Osteosarcoma (OS) is the most common bone tumor in pediatric patients, particularly in adolescents and young adults. Unfortunately, over the past four decades,…”
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Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma by Dasgupta, Atreyi, Sierra, Laura, Tsang, Susan V, Kurenbekova, Lyazat, Patel, Tajhal, Rajapakse, Kimal, Shuck, Ryan L, Rainusso, Nino, Landesman, Yosef, Unger, Thaddeus, Coarfa, Cristian, Yustein, Jason T

“…Rhabdomyosarcoma (RMS) is the most prevalent pediatric soft-tissue sarcoma. Multimodal treatment, including surgery and traditional chemotherapy with…”
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Abstract 6324: Development and characterization of Ewing Sarcoma lung metastasis model by Dasgupta, Atreyi, Kurenbekova, Lyazat, Patel, Tajhal, Yustein, Jason T.

“…Introduction: Ewing Sarcoma (EwS) is the second most common bone tumor in children. At diagnosis, approximately 20-25% of patients with EwS have metastatic…”
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SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells by Zhang, Linda, Hsu, Joanne I, Braekeleer, Etienne D, Chen, Chun-Wei, Patel, Tajhal D, Martell, Alejandra G, Guzman, Anna G, Wohlan, Katharina, Waldvogel, Sarah M, Uryu, Hidetaka, Tovy, Ayala, Callen, Elsa, Murdaugh, Rebecca L, Richard, Rosemary, Jansen, Sandra, Vissers, Lisenka, de Vries, Bert BA, Nussenzweig, Andre, Huang, Shixia, Coarfa, Cristian, Anastas, Jamie, Takahashi, Koichi, Vassiliou, George, Goodell, Margaret A

“…The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase Mg 2+…”
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Abstract 1668: Development and characterization of a c-Myc-driven preclinical mouse model of osteosarcoma to investigate the tumor immune microenvironment by Nirala, Bikesh K., Kurenbekova, Lyazat, Shuck, Ryan L., Patel, Tajhal, Rajapakshe, Kimal, Yustein, Jason T.

“…Osteosarcoma (OS) is the most common bone tumor in pediatric patients, particularly in adolescents and young adults. Currently, no effective molecular targeted…”
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Abstract 6713: Myc-regulated miR17, 20a modulate RANK expression in osteosarcoma by Nirala, Bikesh Kumar, Kurenbekova, Lyazat, Patel, Tajhal, Shuck, Ryan Lane, Dasgupta, Atreyi, Rainusso, Nino Carlo, Yustein, Jason T.

“…Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Approximately 25-30% of these tumors carry amplification of chromosome…”
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Long non-coding RNAs regulation of therapeutic resistance by Tsang, Susan, Patel, Tajhal, Yustein, Jason T

“…Non-protein coding RNAs have emerged as a regulator of cell signaling and cancer progression through regulation of cell proliferation, metastatic burden, and…”
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Abstract 6047: Identification of a 13 gene signature to predict survival in localized osteosarcoma by Patel, Tajhal D., Dholakia, Kshiti, Gandhi, Tanmay R., Kanchi, Rupa S., Grimm, Sandra L., Fu, Chenlian, Yustein, Jason T., Coarfa, Cristian

“…Osteosarcoma (OS) is the most prevalent bone tumor in pediatric patients. Regimens of neoadjuvant chemotherapy have improved survival of OS patients greatly,…”
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