Search Results - "Patel, Shefali"

Diversity and inclusion in the bioanalytical industry: an interview with Shefali R Patel by Patel, Shefali R

“…Shefali is currently Senior Scientist at the Department of Bioanalytical Discovery and Development Sciences at Janssen Research and Development, where she is…”
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Bioanalytical challenges and strategies for accurately measuring acyl glucuronide metabolites in biological fluids by Patel, Shefali R.

“…Bioanalysis of unstable compounds such as acyl glucuronide metabolites represents a great analytical challenge owing to poor analyte stability in biological…”
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Microsampling for quantitative bioanalysis, an industry update: output from an AAPS/EBF survey by Patel, Shefali R, Bryan, Peter, Spooner, Neil, Timmerman, Philip, Wickremsinhe, Enaksha

“…There is continuing interest in the development and application of various microsampling technologies for drug development. The AAPS bioanalytical community…”
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Will patient-centric sampling become the norm for clinical trials after COVID-19? by James, Christopher A., Barfield, Matthew D., Maass, Katie F., Patel, Shefali R., Anderson, Melanie D.

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Perspectives on gender parity in bioanalysis: an interview with Shefali Patel by Patel, Shefali R

“…Shefali R Patel is a Senior Scientist and a Group leader in the Bioanalytical Group within DMPK Department at Janssen (a Johnson & Johnson company). In her…”
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Case Studies on the use of Microsampling for Nonclinical Studies in Pharmaceutical Drug Discovery and Development by Patel, Shefali R., Barricklow, Jason, Bryan, Peter, Rospo, Chiara, Spooner, Neil, Wang, Ming, White, Joleen T., Wilson, Amanda

“…The implementation of microsampling approaches for use in nonclinical discovery and development pharmaceutical studies can have a major impact on improving…”
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Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes by Lin, Yun Hsuan, Duong, Han G., Limary, Abigail E., Kim, Eleanor S., Hsu, Paul, Patel, Shefali A., Wong, William H., Indralingam, Cynthia S., Liu, Yi Chia, Yao, Priscilla, Chiang, Natalie R., Vandenburgh, Sara A., Anderson, Taylor R., Olvera, Jocelyn G., Ferry, Amir, Takehara, Kennidy K., Jin, Wenhao, Tsai, Matthew S., Yeo, Gene W., Goldrath, Ananda W., Chang, John T.

“…Tissue-resident memory CD8+ T (TRM) cells are a subset of memory T cells that play a critical role in limiting early pathogen spread and controlling infection…”
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Follicular Dowling Degos Disease with Lichen Planus in Two Siblings: A Rare Association by Agarwal, Pooja, Jagati, Ashish, Neazee, Sabha, Patel, Shefali

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RORγt phosphorylation protects against T cell-mediated inflammation by Ma, Shengyun, Patel, Shefali A., Abe, Yohei, Chen, Nicholas, Patel, Parth R., Cho, Benjamin S., Abbasi, Nazia, Zeng, Suling, Schnabl, Bernd, Chang, John T., Huang, Wendy Jia Men

“…RAR-related orphan receptor-γ (RORγt) is an essential transcription factor for thymic T cell development, secondary lymphoid tissue organogenesis, and…”
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Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses by Boland, Brigid S, He, Zhaoren, Tsai, Matthew S, Olvera, Jocelyn G, Omilusik, Kyla D, Duong, Han G, Kim, Eleanor S, Limary, Abigail E, Jin, Wenhao, Milner, J Justin, Yu, Bingfei, Patel, Shefali A, Louis, Tiani L, Tysl, Tiffani, Kurd, Nadia S, Bortnick, Alexandra, Quezada, Lauren K, Kanbar, Jad N, Miralles, Ara, Huylebroeck, Danny, Valasek, Mark A, Dulai, Parambir S, Singh, Siddharth, Lu, Li-Fan, Bui, Jack D, Murre, Cornelis, Sandborn, William J, Goldrath, Ananda W, Yeo, Gene W, Chang, John T

“…Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We…”
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Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications by Hsu, Paul, Choi, Eunice J, Patel, Shefali A, Wong, William H, Olvera, Jocelyn G, Yao, Priscilla, Liu, Yi Chia, Tsai, Matthew S, Wang, Wei, Boland, Brigid S, Chang, John T

“…Abstract Background Ulcerative colitis (UC) and Crohn’s disease are 2 types of inflammatory bowel disease (IBD), a group of chronic digestive disorders caused…”
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Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of TH17 cell immunity by Lin, Chia-Hao, Wu, Cheng-Jang, Cho, Sunglim, Patkar, Rasika, Huth, William J., Lin, Ling-Li, Chen, Mei-Chi, Israelsson, Elisabeth, Betts, Joanne, Niedzielska, Magdalena, Patel, Shefali A., Duong, Han G., Gerner, Romana R., Hsu, Chia-Yun, Catley, Matthew, Maciewicz, Rose A., Chu, Hiutung, Raffatellu, Manuela, Chang, John T., Lu, Li-Fan

“…Regulatory T cells (T reg cells) are instrumental in establishing immunological tolerance. However, the precise effector mechanisms by which T reg cells…”
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You Cannot Hit Snooze on OSA: Sequelae of Pediatric Obstructive Sleep Apnea by Thomas, Selena, Patel, Shefali, Gummalla, Prabhavathi, Tablizo, Mary Anne, Kier, Catherine

“…Pediatric obstructive sleep apnea (OSA) has been shown to not only affect the quality of sleep, but also overall health in general. Untreated or inadequately…”
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Leveraging patient‐centric sampling for clinical drug development and decentralized clinical trials: Promise to reality by Maass, Katie F., Barfield, Matthew D., Ito, Mototsugu, James, Christopher A., Kavetska, Olga, Kozinn, Marc, Kumar, Parag, Lepak, Maureen, Leuthold, Luc Alexis, Li, Wenkui, Mikhailov, Dmitri, Patel, Shefali, Perez, Nisha L., Jackson Rudd, Deanne, Vakkalagadda, Blisse, Williams, Tracy M., Zha, Jiuhong, Zhang, Xin, Anderson, Melanie D.

“…Advances in the technologies to enable patient‐centric sampling (PCS) have the potential to improve blood sample collection by enabling clinical trial…”
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Analysis of dendritic cells and ischemia-reperfusion changes in postimplantation renal allograft biopsies may serve as predictors of subsequent rejection episodes by Batal, Ibrahim, Mohan, Sumit, De Serres, Sacha A, Vasilescu, Elena-Rodica, Tsapepas, Demetra, Crew, Russel J, Patel, Shefali S, Serban, Geo, McCune, Kasi, Husain, Syed A, Chang, Jae-Hyung, Herter, Jan M, Bhagat, Govind, Markowitz, Glen S, D'Agati, Vivette D, Hardy, Mark A, Ratner, Lloyd, Chandraker, Anil

“…Ischemia-reperfusion injury increases allograft immunogenicity and enhances myeloid dendritic cell maturation and trafficking to recipient's secondary lymphoid…”
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Identification of CD8 + T-Cell–Immune Cell Communications in Ileal Crohn's Disease by Duong, Han G., Choi, Eunice J., Hsu, Paul, Chiang, Natalie R., Patel, Shefali A., Olvera, Jocelyn G., Liu, Yi Chia, Lin, Yun Hsuan, Yao, Priscilla, Wong, William H., Indralingam, Cynthia S., Tsai, Matthew S., Boland, Brigid S., Wang, Wei, Chang, John T.

“…Crohn's disease (CD) is a major subtype of inflammatory bowel disease (IBD), a spectrum of chronic intestinal disorders caused by dysregulated immune responses…”
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Biodiversity and Abundance of Phytoplankton from Auranga Estuary, Valsad District, Gujarat, India by PATEL, Shefali S., SAHOO, Susmita

“…This study describes phytoplankton abundance and diversity from site 1 (downstream) and site 2 (upstream) of Auranga Estuary (20˚63’ N and 72˚82’ E). A Total…”
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Solute concentration prediction using chemometrics and ATR-FTIR spectroscopy by Togkalidou, Timokleia, Fujiwara, Mitsuko, Patel, Shefali, Braatz, Richard D

“…The fundamental processes of crystal nucleation and growth are strongly dependent on the solute concentration. A significant limitation to the development of…”
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Randomised trial comparing assist control and pressure support ventilation during weaning by Shefali-Patel, D, Hannam, S, Lee, S, Rafferty, G, Greenough, A

“…Aim Assist control ventilation (ACV) compared to pressure limited, time cycled ventilation is associated with shorter duration of weaning. During both ACV and…”
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Efficacy of Episodic Use of Montelukast in Preschool Children with Intermittent Wheezing by Surana, Amita Uday, Patel, Shefali Bhagubhai, Chaudhary, Falguni Vipul, Patel, Snehal Subodhbhai, Ansari, Rehan Naimullah, Pathan, Rummankhan Rashidkhan

“…Introduction: Acute intermittent wheezing illnesses are frequent occurrences in preschool children and need better management strategies. Montelukast, a…”
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