Search Results - "Patel, Ramesh N"

Biocatalysis for synthesis of pharmaceuticals by Patel, Ramesh N.

“…[Display omitted] Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug…”
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Biocatalytic synthesis of chiral alcohols and amino acids for development of pharmaceuticals by Patel, Ramesh N

“…Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has…”
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Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase from Bacillus megaterium by Hanson, Ronald L., Davis, Brian L., Chen, Yijun, Goldberg, Steven L., Parker, William L., Tully, Thomas P., Montana, Michael A., Patel, Ramesh N.

“…Screening was carried out to identify strains useful for the preparation of (R)‐1‐cyclopropylethylamine and (R)‐sec‐butylamine by resolution of the racemic…”
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Synthesis of chiral pharmaceutical intermediates by biocatalysis by Patel, Ramesh N.

“…Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates has become…”
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Biocatalysis: Synthesis of Key Intermediates for Development of Pharmaceuticals by Patel, Ramesh N

“…Chirality is a key factor for the safety and efficacy of many drug products. The production of single enantiomers of drug intermediates has become increasingly…”
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Microbial/enzymatic synthesis of chiral intermediates for pharmaceuticals by Patel, Ramesh N

“…There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-,…”
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Biocatalytic synthesis of intermediates for the synthesis of chiral drug substances by Patel, Ramesh N

“…There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-,…”
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Enzymatic Synthesis of Chiral Intermediates for Drug Development by Patel, Ramesh N.

“…Chirality is a key factor in the efficacy of many drug products and thus the production of single enantiomers of drug intermediates has become increasingly…”
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Preparation of an Amino Acid Intermediate for the Dipeptidyl Peptidase IV Inhibitor, Saxagliptin, using a Modified Phenylalanine Dehydrogenase by Hanson, Ronald L., Goldberg, Steven L., Brzozowski, David B., Tully, Thomas P., Cazzulino, Dana, Parker, William L., Lyngberg, Olav K., Vu, Truc C., Wong, Michael K., Patel, Ramesh N.

“…The non‐proteinogenic amino acid 2‐(3‐hydroxy‐1‐adamantyl)‐(2S)‐aminoethanoic acid [2, (S)‐3‐hydroxyadamantylglycine], is a key intermediate required for the…”
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Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates by Ramesh N. Patel

“…The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine…”
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Hydroxylation of l-proline to cis-3-hydroxy- l-proline by recombinant Escherichia coli expressing a synthetic l-proline-3-hydroxylase gene by Johnston, Robert M., Chu, Linda N., Liu, Mark, Goldberg, Steven L., Goswami, Animesh, Patel, Ramesh N.

“…A synthetic gene encoding a Streptomyces l-proline-3-hydroxylase was constructed and used to produce the hydroxylase protein in recombinant Escherichia coli. A…”
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TOUR DE PACLITAXEL: Biocatalysis for Semisynthesis by Patel, Ramesh N

“…In collaboration with the National Cancer Institute, Bristol-Myers Squibb has developed paclitaxel for treatment of various cancers; it has been approved by…”
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Enantioselective microbial reduction of substituted acetophenones by Patel, Ramesh N, Goswami, Animesh, Chu, Linda, Donovan, Mary Jo, Nanduri, Venkata, Goldberg, Steven, Johnston, Robert, Siva, Prasad J, Nielsen, Brent, Fan, Junying, He, WeiXuan, Shi, Zhongping, Wang, Kwok Y, Eiring, Ronald, Cazzulino, Dana, Singh, Ambarish, Mueller, Richard

“…Graphic The chiral intermediate ( S)-1-(2′-bromo-4′-fluoro phenyl)ethanol 2 was prepared by the enantioselective microbial reduction of 2-bromo-4-fluoro…”
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Synthesis of ethyl-(3 R,5 S)-dihydroxy-6-benzyloxyhexanoates via diastereo- and enantioselective microbial reduction: Cloning and expression of ketoreductase III from Acinetobacter sp. SC 13874 by Goldberg, Steven, Guo, Zhiwei, Chen, Steve, Goswami, Animesh, Patel, Ramesh N.

“…Previously we have demonstrated the reduction of ethyl and t-butyl diketoesters 1 to the corresponding syn-(3 R,5 S)-dihydroxy esters 2a by Acinetobacter sp…”
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Enzymes for the removal of N-carbobenzyloxy protecting groups from N-carbobenzyloxy-d- and l-amino acids by Chu, Linda N., Nanduri, Venkata B., Patel, Ramesh N., Goswami, Animesh

“…[Display omitted] ► Enzymes for the hydrolysis of N-carbobenzyloxy amino acids. ► Selective deprotection of N-CBz d- or l-amino acids. ► Enzymatic resolution…”
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Enzymatic Reduction of Adamantanones to Chiral Adamantanol Intermediates for the Synthesis of 11-β-Hydroxysteroid Dehydrogenase Inhibitors by Hanson, Ronald L, Goldberg, Steven L, Guo, Zhiwei, Tully, Thomas P, Goswami, Animesh, Ye, Xiang-Yang, Robl, Jeffrey A, Patel, Ramesh N

“…An enzymatic reduction process was developed to convert the ketone 2-(6-oxo-2-phenyladamantan-2-yl)acetic acid to the chiral alcohol 2-((2S,…”
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Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid by Chen, Yijun, Goldberg, Steven L, Hanson, Ronald L, Parker, William L, Gill, Iqbal, Tully, Thomas P, Montana, Michael A, Goswami, Animesh, Patel, Ramesh N

“…The (S)-amino acid, (S)-2-amino-3-(6-o-tolylpyridin-3-yl)propanoic acid (3), is a key intermediate needed for synthesis of an antidiabetic drug candidate…”
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Microbial transformation of 2-amino-4-methyl-3-nitropyridine by Tully, Thomas, Liu, Mark, Huang, Yande, Ye, Qingmei, Patel, Ramesh N, Goswami, Animesh

“…Biotransformation of the highly substituted pyridine derivative 2-amino-4-methyl-3-nitropyridine by Cunninghamella elegans ATCC 26269 yielded three products…”
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Purification and Cloning of a Ketoreductase used for the Preparation of Chiral Alcohols by Hanson, Ronald L., Goldberg, Steven, Goswami, Animesh, Tully, Thomas P., Patel, Ramesh N.

“…The synthesis of the leading candidate compound in an anticancer program required (S)‐2‐chloro‐1‐(3‐chlorophenyl)‐ethanol as an intermediate. Other possible…”
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Enzymatic Preparation of a d-Amino Acid from a Racemic Amino Acid or Keto Acid by Hanson, Ronald L, Davis, Brian L, Goldberg, Steven L, Johnston, Robert M, Parker, William L, Tully, Thomas P, Montana, Michael A, Patel, Ramesh N

“…The d-amino acid (R)-2-amino-3-(7-methyl-1 H-indazol-5-yl)propanoic acid (3) is a key intermediate needed for synthesis of a drug candidate compound. Enzymatic…”
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