Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy

Comorbid hepatitis C does not modulate prevalence or severity of diabetic retinopathy

There are limited and conflicting data regarding the impact of comorbid hepatitis C virus (HCV) infection on diabetic retinopathy (DR). This study sought to compare the prevalence and severity of DR among patients with diabetes mellitus (DM) with and without HCV. This was a retrospective, case-contr...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) Vol. 13; pp. 1681 - 1687
Main Authors: Koenig, Lisa R, Rosenblatt, Russell, Patel, Rahil M, Wu, Yiyuan, Papakostas, Thanos D, Orlin, Anton, Chan, Robison V Paul, Kiss, Szilard, D'Amico, Donald J, Kumar, Sonal, Gupta, Mrinali P
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-09-2019
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects:
Age
Biological response modifiers
Care and treatment
cirrhosis
Comorbidity
Comparative analysis
Diabetes
diabetes mellitus
Diabetic retinopathy
Diabetics
Glycosylated hemoglobin
Health care policy
Hemoglobins
Hepatitis
Hepatitis C
Hepatitis C virus
Hepatology
HIV
Human immunodeficiency virus
Infection
Infections
Insulin resistance
Interferon
Liver cirrhosis
Liver diseases
Medical research
Medicine
Metabolism
Original Research
Patients
Prevalence studies (Epidemiology)
retinopathy
Software
Studies
Transplants & implants
Type 2 diabetes
Viral infections
New York
United States > US
diabetes mellitus
hepatitis
retinopathy
cirrhosis
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Summary:There are limited and conflicting data regarding the impact of comorbid hepatitis C virus (HCV) infection on diabetic retinopathy (DR). This study sought to compare the prevalence and severity of DR among patients with diabetes mellitus (DM) with and without HCV. This was a retrospective, case-control study of patients with DM comparing 120 patients with comorbid HCV and 120 age-matched controls. DR prevalence and several measures of severity were compared between groups. Subgroup analyses were performed among HCV patients with cirrhosis, comorbid HIV, or history of treatment with interferon. Statistical analysis for between-group comparisons utilized both univariate and multivariate analyses. Cases and controls exhibited similar baseline characteristics: average hemoglobin A1c, DM duration, and age ( >0.05). Among cases and controls, there was no difference in DR prevalence (35.8% versus 42.5%, respectively, =0.29) or severity ( >0.05). Within the HCV subgroup, DR severity was reduced in patients with HIV or cirrhosis. However, multivariate analysis identified reduced DM duration in these subgroups as the primary contributor to lesser DR severity, rather than HIV or cirrhosis. In this study, comorbid HCV did not modulate the prevalence or severity of DR among patients with DM. These findings may inform clinical monitoring among HCV-positive diabetics undergoing ophthalmic evaluation.
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ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S209274