Search Results - "Patel, Parth N"

A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial by Mehta, Nehal N, Heffron, Sean P, Patel, Parth N, Ferguson, Jane, Shah, Rachana D, Hinkle, Christine C, Krishnamoorthy, Parasuram, Shah, Rhia, Tabita-Martinez, Jennifer, Terembula, Karen, Master, Stephen R, Rickels, Michael R, Reilly, Muredach P

“…Chronic inflammation may contribute to insulin resistance (IR), metabolic syndrome and atherosclerosis although evidence of causality is lacking in humans. We…”
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Cardiovascular risk reduction with icosapent ethyl by Patel, Parth N, Patel, Siddharth M, Bhatt, Deepak L

“…PURPOSE OF REVIEWResidual risk for atherosclerotic cardiovascular disease (ASCVD) persists even among patients with optimal low-density lipoprotein cholesterol…”
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Identification of pathogenic gene mutations in LMNA and MYBPC3 that alter RNA splicing by Ito, Kaoru, Patel, Parth N., Gorham, Joshua M., McDonough, Barbara, DePalma, Steven R., Adler, Emily E., Lam, Lien, MacRae, Calum A., Mohiuddin, Syed M., Fatkin, Diane, Seidman, Christine E., Seidman, J. G.

“…Genetic variants that cause haploinsufficiency account for many autosomal dominant (AD) disorders. Gene-based diagnosis classifies variants that alter…”
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Human Experimental Endotoxemia in Modeling the Pathophysiology, Genomics, and Therapeutics of Innate Immunity in Complex Cardiometabolic Diseases by Patel, Parth N, Shah, Rhia Y, Ferguson, Jane F, Reilly, Muredach P

“…Inflammation is a fundamental feature of several complex cardiometabolic diseases. Indeed, obesity, insulin resistance, metabolic dyslipidemia, and…”
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Virtual optimization of guideline‐directed medical therapy in hospitalized patients with heart failure with reduced ejection fraction: the IMPLEMENT‐HF pilot study by Bhatt, Ankeet S., Varshney, Anubodh S., Nekoui, Mahan, Moscone, Alea, Cunningham, Jonathan W., Jering, Karola S., Patel, Parth N., Sinnenberg, Lauren E., Bernier, Thomas D., Buckley, Leo F., Cook, Bryan M., Dempsey, Jillian, Kelly, Julie, Knowles, Danielle M., Lupi, Kenneth, Malloy, Rhynn, Matta, Lina S., Rhoten, Megan N., Sharma, Krishan, Snyder, Caroline A., Ting, Clara, McElrath, Erin E., Amato, Mary G., Alobaidly, Maryam, Ulbricht, Catherine E., Choudhry, Niteesh K., Adler, Dale S., Vaduganathan, Muthiah

“…Aims Implementation of guideline‐directed medical therapy (GDMT) for heart failure with reduced ejection fraction (HFrEF) remains incomplete…”
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Clinical Application of a Novel Genetic Risk Score for Ischemic Stroke in Patients With Cardiometabolic Disease by Marston, Nicholas A., Patel, Parth N., Kamanu, Frederick K., Nordio, Francesco, Melloni, Giorgio M., Roselli, Carolina, Gurmu, Yared, Weng, Lu-Chen, Bonaca, Marc P., Giugliano, Robert P., Scirica, Benjamin M., O’Donoghue, Michelle L., Cannon, Christopher P., Anderson, Christopher D., Bhatt, Deepak L., Gabriel Steg, Philippe, Cohen, Marc, Storey, Robert F., Sever, Peter, Keech, Anthony C., Raz, Itamar, Mosenzon, Ofri, Antman, Elliott M., Braunwald, Eugene, Ellinor, Patrick T., Lubitz, Steven A., Sabatine, Marc S., Ruff, Christian T.

“…Genome-wide association studies have identified single-nucleotide polymorphisms that are associated with an increased risk of stroke. We sought to determine…”
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A functional synonymous coding variant in the IL1RN gene is associated with survival in septic shock by Meyer, Nuala J, Ferguson, Jane F, Feng, Rui, Wang, Fan, Patel, Parth N, Li, Mingyao, Xue, Chenyi, Qu, Liming, Liu, Yichuan, Boyd, John H, Russell, James A, Christie, Jason D, Walley, Keith R, Reilly, Muredach P

“…Death from infection is a highly heritable trait, yet there are few genetic variants with known mechanism influencing survival during septic shock. We…”
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A Dorsal Epidural Herniated Disc Fragment Initially Presenting as Guillain-Barré Syndrome by Patel, Parth N, Schloss, Michael G, Sharma, Kaveri, Dulai, Poonam

“…Guillain-Barré syndrome (GBS) is a rare autoimmune disorder that presents with neurological symptoms that can mimic other conditions. This mimicry can hide…”
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Low-density lipoprotein cholesterol lowering therapy for the secondary prevention of atherosclerotic cardiovascular disease by Patel, Parth N, Giugliano, Robert P

“…Atherosclerotic cardiovascular disease (ASCVD) is highly prevalent and a major contributor to morbidity and mortality worldwide. Elevated blood cholesterol is…”
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Race and gender variation in response to evoked inflammation by Ferguson, Jane F, Patel, Parth N, Shah, Rhia Y, Mulvey, Claire K, Gadi, Ram, Nijjar, Prabhjot S, Usman, Haris M, Mehta, Nehal N, Shah, Rachana, Master, Stephen R, Propert, Kathleen J, Reilly, Muredach P

“…Race- and gender-variation in innate immunity may contribute to demographic differences in inflammatory and cardiometabolic disease; yet their influence on…”
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Omega-3 PUFA supplementation and the response to evoked endotoxemia in healthy volunteers by Ferguson, Jane F., Mulvey, Claire K., Patel, Parth N., Shah, Rhia Y., Doveikis, Julia, Zhang, Weiyu, Tabita-Martinez, Jennifer, Terembula, Karen, Eiden, Michael, Koulman, Albert, Griffin, Julian L., Mehta, Nehal N., Shah, Rachana, Propert, Kathleen J., Song, Wen-Liang, Reilly, Muredach P.

“…Scope Fish oil‐derived n‐3 PUFA may improve cardiometabolic health through modulation of innate immunity. However, findings in clinical studies are…”
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The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels by MEHTA, Nehal N, MINGYAO LI, PATEL, Parth N, BRADFIELD, Jonathan P, JING HE, STYLIANOU, Loannis M, HAKONARSON, Hakon, RADER, Daniel J, REILLY, Muredach P, WILLIAM, Dilusha, KHERA, Amit V, DEROHANNESSIAN, Stephanie, LIMING QU, FERGUSON, Jane F, MCLAUGHLIN, Catherine, HARIS SHAIKH, Lalarukh, SHAH, Rhia

“…Two single-nucleotide polymorphisms (SNPs), rs1746048 and rs501120, from genome wide association studies of coronary artery disease (CAD) map to chromosome…”
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In vivo and In vitro methods to identify DNA sequence variants that alter RNA Splicing by Patel, Parth N, Gorham, Joshua M, Ito, Kaoru, Seidman, Christine E

“…Identification of sequence variants that create or eliminate splice sites has proven to be a significant challenge and represents one of many roadblocks in the…”
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Contribution of Noncanonical Splice Variants to TTN Truncating Variant Cardiomyopathy by Patel, Parth N., Ito, Kaoru, Willcox, Jon A.L., Haghighi, Alireza, Jang, Min Young, Gorham, Joshua M., DePalma, Steven R., Lam, Lien, McDonough, Barbara, Johnson, Renee, Lakdawala, Neal K., Roberts, Amy, Barton, Paul J.R., Cook, Stuart A., Fatkin, Diane, Seidman, Christine E., Seidman, J.G.

“…Heterozygous truncating variants cause 10% to 20% of idiopathic dilated cardiomyopathy (DCM). Although variants which disrupt canonical splice signals (ie,…”
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Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease by Jang, Min Young, Patel, Parth N., Pereira, Alexandre C., Willcox, Jon A.L., Haghighi, Alireza, Tai, Angela C., Ito, Kaoru, Morton, Sarah U., Gorham, Joshua M., McKean, David M., DePalma, Steven R., Bernstein, Daniel, Brueckner, Martina, Chung, Wendy K., Giardini, Alessandro, Goldmuntz, Elizabeth, Kaltman, Jonathan R., Kim, Richard, Newburger, Jane W., Shen, Yufeng, Srivastava, Deepak, Tristani-Firouzi, Martin, Gelb, Bruce D., Porter, George A., Seidman, Christine E., Seidman, Jonathan G.

“…Known genetic causes of congenital heart disease (CHD) explain <40% of CHD cases, and interpreting the clinical significance of variants with uncertain…”
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Peroxisome Proliferator–Activated Receptor‐α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia by Mulvey, Claire K., Ferguson, Jane F., Tabita‐Martinez, Jennifer, Kong, Stephanie, Shah, Rhia Y., Patel, Parth N., Master, Stephen R., Usman, M. Haris U., Propert, Kathleen J., Shah, Rachana, Mehta, Nehal N., Reilly, Muredach P.

“…Background Data conflict with regard to whether peroxisome proliferator–activated receptor‐α agonism suppresses inflammation in humans. We hypothesized that in…”
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Autonomic Instability Secondary to Glomus Vagale Paraganglioma by Patel, Parth N., Berman, Joseph J.

“…Paragangliomas are rare vascular neuroendocrine tumors that arise from neural crest chromaffin cells that are associated with autonomic ganglion. A small…”
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30 Day Readmissions After Transcatheter Aortic Valve Replacement by Patel, Parth N., Gopal, Shwetha, Hilden, Patrick, Mistry, Nirav

“…Background: As the number of centers performing Transcatheter Aortic Valve Replacement (TAVR) continue to proliferate, it has become increasingly important to…”
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Abstract 467: Identification of Novel Pathogenic Mutations in Non-Canonical RNA Splice Sites in Congenital Heart Disease by Jang, Min Young, Tai, Angela C, Patel, Parth N, Ito, Kaoru, Gorham, Joshua, Pereira, Alexandre C, McKean, David M, Seidman, Christine E, Seidman, J G

“…Abstract only Rationale: Congenital heart disease (CHD) occurs in about 1 in 100 live births, yet known genetic causes explain less than 20% of CHD cases…”
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Abstract 772: The Highly Prevalent 25bp Intronic Deletion in MYBPC3 is Benign Under Baseline Conditions by McNamara, James W, Schwanekamp, Jennifer A, Patel, Parth N, Viswanathan, Shiv K, Bohlooly, Mohammad, Madeyski-Bengtson, Katja, Knöll, Ralph, Seidman, Jonathan G, Seidman, Christine E, Sadayappan, Sakthivel

“…Abstract only Background: Hypertrophic cardiomyopathy (HCM) affects at least 1 in 500 people worldwide, and results in the thickening of the ventricular walls…”
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