Search Results - "Patel, Om P. S."

Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives by Nandwana, Nitesh K, Patel, Om P S, Mehra, Manish K, Kumar, Anil, Salvino, Joseph M

“…Quinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal…”
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Design and Synthesis of Imidazo/Benzimidazo[1,2‑c]quinazoline Derivatives and Evaluation of Their Antimicrobial Activity by Nandwana, Nitesh Kumar, Singh, Rajnish Prakash, Patel, Om P. S, Dhiman, Shiv, Saini, Hitesh Kumar, Jha, Prabhat N, Kumar, Anil

“…A new class of fused quinazolines has been designed and synthesized via copper-catalyzed Ullmann type C–N coupling followed by intramolecular…”
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Dual Role of Glyoxal in Metal-Free Dicarbonylation Reaction: Synthesis of Symmetrical and Unsymmetrical Dicarbonyl Imidazoheterocycles by Nandwana, Nitesh Kumar, Patel, Om P. S, Srivathsa, Manu R, Kumar, Anil

“…A practical and efficient method has been developed for the dicarbonylation of imidazoheterocycles using glyoxals as dicarbonyl precursors under metal-free…”
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H2O2/DMSO-Promoted Regioselective Synthesis of 3,3′-Bisimidazopyridinylmethanes via Intermolecular Oxidative C(sp2)–H Bond Activation of Imidazoheterocycles by Patel, Om P. S, Anand, Devireddy, Maurya, Rahul K, Yadav, Prem P

“…In the past decade, metal-free approaches for C–C bond formation have attracted a great deal of attention due to their ease of use and low cost. This report…”
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Antileishmanial Activity of Pyrazolopyridine Derivatives and Their Potential as an Adjunct Therapy with Miltefosine by Anand, Devireddy, Yadav, Pawan Kumar, Patel, Om P. S, Parmar, Naveen, Maurya, Rahul K, Vishwakarma, Preeti, Raju, Kanumuri S. R, Taneja, Isha, Wahajuddin, M, Kar, Susanta, Yadav, Prem P

“…A series of pyrazolo­(dihydro)­pyridines was synthesized and evaluated for antileishmanial efficacy against experimental visceral leishmaniasis (VL). Among all…”
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Substrate Controlled Synthesis of Benzisoxazole and Benzisothiazole Derivatives via PhI(OAc)2‑Mediated Oxidation Followed by Intramolecular Oxidative O–N/S–N Bond Formation by Anand, Devireddy, Patel, Om P. S, Maurya, Rahul K, Kant, Ruchir, Yadav, Prem P

“…A phenyliodine­(III) diacetate (PIDA)-mediated, highly efficient and tandem approach for the synthesis of aryldiazenylisoxazolo­(isothiazolo)­arenes from…”
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Naturally Occurring Carbazole Alkaloids from Murraya koenigii as Potential Antidiabetic Agents by Patel, Om P. S, Mishra, Akansha, Maurya, Ranjani, Saini, Deepika, Pandey, Jyotsana, Taneja, Isha, Raju, Kanumuri S. R, Kanojiya, Sanjeev, Shukla, Sanjeev K, Srivastava, Mahendra N, Wahajuddin, M, Tamrakar, Akhilesh K, Srivastava, Arvind K, Yadav, Prem P

“…This study identified koenidine (4) as a metabolically stable antidiabetic compound, when evaluated in a rodent type 2 model (leptin receptor-deficient db/db…”
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Role of Glycation in Type 2 Diabetes Mellitus and Its Prevention through Nymphaea Species by Ishrat, Nayab, Khan, Hamda, Patel, Om P. S., Mahdi, Abbas Ali, Mujeeb, Farina, Ahmad, Saheem

“…The dysregulation of glucose metabolism that includes the modification of biomolecules with the help of glycation reaction results in the formation of advanced…”
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Antimalarial application of quinones: A recent update by Patel, Om P.S., Beteck, Richard M., Legoabe, Lesetja J.

“…Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with proguanil (Malarone) for the treatment of acute, uncomplicated malaria…”
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Recent Advances in Radical C−H Bond Functionalization of Imidazoheterocycles by Patel, Om P. S., Nandwana, Nitesh K., Legoabe, Lesetja J., Das, Bhaskar C., Kumar, Anil

“…Direct C−H bond functionalization through radical pathway has emerged as a powerful and ideal strategy for the synthesis of organic compounds. This review…”
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Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research by Patel, Om P.S., Beteck, Richard M., Legoabe, Lesetja J.

“…Malaria is a life-threatening infectious disease caused by protozoal parasites belonging to the genus Plasmodium. It caused an estimated 405,000 deaths and 228…”
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Metronidazole-conjugates: A comprehensive review of recent developments towards synthesis and medicinal perspective by Patel, Om P.S., Jesumoroti, Omobolanle Janet, Legoabe, Lesetja J., Beteck, Richard M.

“…Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry due to their numerous biological activities. Moreover, many clinical…”
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Phenyliodine(III) Diacetate-Mediated 1,2- ipso -Migration in Mannich Bases of Imidazo[1,2- a ]pyridines: Preparation of N -Acetoxymethyl/Alkoxymethyl- N -arylimidazo[1,2- a ]pyridine-3-amines by Patel, Om P S, Jaspal, Sonam, Shinde, Vikki N, Nandwana, Nitesh K, Rangan, Krishnan, Kumar, Anil

“…Phenyliodine(III) diacetate -mediated 1,2- -migration of an imidazo[1,2- ]pyridine ring via the formation of an aziridine intermediate in Mannich bases derived…”
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Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis by Arun, Ashutosh, Patel, Om P.S., Saini, Deepika, Yadav, Prem P., Konwar, Rituraj

“…[Display omitted] In recent years, many alkaloids of plant origin have attracted great attention due to their diverse range of biological properties including…”
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Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells by Patel, Om P.S., Arun, Ashutosh, Singh, Pankaj K., Saini, Deepika, Karade, Sharanbasappa Shrimant, Chourasia, Manish K., Konwar, Rituraj, Yadav, Prem P.

“…A series of new pyranocarbazole derivatives were synthesized via semi-synthetic modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of…”
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Metal-free synthesis of pyridin-2-yl ureas from 2-aminopyridinium salts by Saroj, Patel, Om P.S., Rangan, Krishnan, Kumar, Anil

“…[Display omitted] •Metal-free, base mediated synthesis of pyridin-2-yl urea derivatives.•Good to moderate (29–66%) yields of pyridin-2-yl urea…”
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H 2 O 2 /DMSO-Promoted Regioselective Synthesis of 3,3′-Bisimidazopyridinylmethanes via Intermolecular Oxidative C(sp 2 )–H Bond Activation of Imidazoheterocycles by Patel, Om P. S., Anand, Devireddy, Maurya, Rahul K., Yadav, Prem P.

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Design and Synthesis of Imidazo/Benzimidazo1,2-cquinazoline Derivatives and Evaluation of Their Antimicrobial Activity by Nandwana, Nitesh Kumar, Singh, Rajnish Prakash, Patel, Om P S, Dhiman, Shiv, Saini, Hitesh Kumar, Jha, Prabhat N, Kumar, Anil

“…A new class of fused quinazolines has been designed and synthesized via copper-catalyzed Ullmann type C-N coupling followed by intramolecular…”
Get full text