Search Results - "Patel, Niren"

Characteristics of sickle cell patients with frequent emergency department visits and hospitalizations by Kidwell, Kyle, Albo, Camila, Pope, Michael, Bowman, Latanya, Xu, Hongyan, Wells, Leigh, Barrett, Nadine, Patel, Niren, Allison, Amy, Kutlar, Abdullah

“…Vaso-occlusive episodes (VOEs) are a hallmark of sickle cell disease (SCD), and account for >90% of health care encounters for this patient population. The…”
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Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness by Zhu, Xingguo, Hu, Tianxiang, Ho, Meng Hsuan, Wang, Yongchao, Yu, Miao, Patel, Niren, Pi, Wenhu, Choi, Jeong-Hyeon, Xu, Hongyan, Ganapathy, Vadivel, Kutlar, Ferdane, Kutlar, Abdullah, Tuan, Dorothy

“…Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treating patients with sickle cell disease (SCD), produces…”
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Two New γ Chain Variants: Hb F-Augusta GA [Gγ59(E3)Lys → Arg; HBG2: c.179A > G] and Hb F-Port Royal-II [Aγ125(H3)Glu → Ala; HBG1: c.377A > C] by Kutlar, Ferdane, Ameri, Afshin, Patel, Niren H., Zhuang, Lina, Johnson, Lee E., Cheng, Michael L., Kutlar, Abdullah

“…Abstract The total number of hemoglobin (Hb) variants so far reported to the HbVar database is 1598 (April 9 2014) and 130 of them are fetal Hb variants. Fetal…”
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Proteomics of Plasma from Patients with Sickle Cell Disease with and without Chronic Pain: A Pilot Biomarker Discovery Study by Casey, Mycal, Gramazio, Brandon, Urum, Florence, Patel, Niren, Zhi, Wenbo, Kutlar, Abdullah

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Downregulation of Cytoskeletal Protein Kazrin in Lung Endothelial Cells of Preclinical Sickle Cell Disease Mouse Model - Essential Role of Endothelial Barrier Function by Siddaramappa, Umapathy N, Patel, Niren, Pace, Betty S., Kutlar, Abdullah

“…Background: Lung capillary barrier dysfunction is common to all causes of acute chest syndrome (ACS), a leading cause of morbidity and mortality in individuals…”
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Preclinical and Clinical Use of AB1, a DNMT1 Protein Depleter, to Upregulate Fetal Hemoglobin in Townes Sickle Cell Disease (SCD) Mice and Patients with SCD by Shah, Nirmish, Raval, Girindra, Kutlar, Abdullah, Patel, Niren, Takezaki, Mayuko, Li, Biaoru, Alagar, Manickam, Xu, Hongyan, Blackburn, Kelly, Vadivelu, Santhosh, Schaub, Robert, Santos, David, Pace, Betty

“…Background: Sickle Cell Disease (SCD) is an inherited hematologic disorder characterized by lifelong hemolysis, vaso-occlusion and severe complications…”
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Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia—TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial by Ware, Russell E, Prof, Davis, Barry R, Prof, Schultz, William H, MHS PA, Brown, R Clark, MD PhD, Aygun, Banu, MD, Sarnaik, Sharada, Prof, Odame, Isaac, Prof, Fuh, Beng, MD, George, Alex, MD PhD, Owen, William, MD, Luchtman-Jones, Lori, Prof, Rogers, Zora R, Prof, Hilliard, Lee, Prof, Gauger, Cynthia, MD, Piccone, Connie, MD, Lee, Margaret T, MD, Kwiatkowski, Janet L, MD MSCE, Jackson, Sherron, MD, Miller, Scott T, Prof, Roberts, Carla, MD, Heeney, Matthew M, MD, Kalfa, Theodosia A, MD PhD, Nelson, Stephen, MD, Imran, Hamayun, MD, Nottage, Kerri, MD MPH, Alvarez, Ofelia, Prof, Rhodes, Melissa, MD, Thompson, Alexis A, Prof, Rothman, Jennifer A, MD, Helton, Kathleen J, MD, Roberts, Donna, MD, Coleman, Jamie, MD, Bonner, Melanie J, Prof, Kutlar, Abdullah, Prof, Patel, Niren, MD, Wood, John, MD PhD, Piller, Linda, MD, Wei, Peng, PhD, Luden, Judy, CCRC, Mortier, Nicole A, MHS PA-C, Stuber, Susan E, MA, Luban, Naomi L C, Prof, Cohen, Alan R, Prof, Pressel, Sara, MS, Adams, Robert J, Prof

“…Summary Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow velocities, regular blood transfusions can effectively…”
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Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters by Kuo, Kevin H.M., Singer, Sylvia Titi, Blyden, Gershwin Theophilus, Bronté-Hall, Lanetta, Faller, Aidan, Kutlar, Abdullah, Kuypers, Frans A., Zaidi, Aliya U., Hines, Patrick C., Patel, Niren, Larkin, Sandra, Al-Samkari, Hanny, Sheth, Sujit, Nouraie, Seyed Mehdi, Perrine, Susan

“…Extensive evidence has shown fetal hemoglobin (HbF) is a major modulator of sickle cell disease (SCD) phenotype. Clinical benefit with any increment of HbF was…”
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ETA Receptor Blockade and Vascular Function in Patients with Sickle Cell Disease by Adamkiewicz, Daniel, Xu, Hongyan, Bowman, Latanya, Wells, Leigh, Patel, Niren, Harris, Ryan, Pollock, Jennifer, Pollock, David M., Meiler, Steffen E., Kutlar, Abdullah

“…Endothelin-1 (ET1) is a potent vasoconstrictor, mitogen, proinflammatory mediator, and a mediator of nociception, whose synthesis is increased by hypoxia,…”
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Erythroferrone (ERFE) and Hepcidin Levels in Sickle Cell Disease with and without Transfusional Iron Overload by Thawer, Fahim, Kutlar, Abdullah, Bowman, Latanya, Wells, Leigh, Hongyan, Xu, Patel, Niren, Bora, Pritam

“…Transfusional iron (Fe) overload is not rare among patients with sickle cell disease (SCD) and can lead to significant morbidity and even mortality. We…”
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Correlation of Serum Ferritin Levels with Liver Iron Concentration By MRI Measurement in Sickle Cell Patients with Transfusional Iron Overload by Ajebo, Germame, Mangaonkar, Abhishek A., Ahmad, Imran, Barrett, Nadine, Wells, Leigh, Patel, Niren, Xu, Hongyan, Kutlar, Abdullah

“…Background: Recent reports from the thalassemia literature suggest that serum ferritin may be a poor and possibly misleading measure of total iron store in…”
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Regulation of iron homeostasis through the erythroferrone‐hepcidin axis in sickle cell disease by Mangaonkar, Abhishek A., Thawer, Fahim, Son, James, Ajebo, Germame, Xu, Hongyan, Barrett, Nadine J., Wells, Leigh G., Bowman, Latanya, Clair, Betsy, Patel, Niren, Bora, Pritam, Jung, Grace, Nemeth, Elizabeta, Kutlar, Abdullah

“…Summary Sickle cell disease (SCD) has a distinct pattern of transfusional iron overload (IO) when compared to transfusion‐dependent β‐thalassaemia major (TDT)…”
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Survival of transfused red blood cells from a donor with alpha‐thalassemia trait in a recipient with sickle cell disease by Yee, Marianne E. M., Covington, Mischa L., Zerra, Patricia E., McCoy, James W., Easley, Kirk A., Joiner, Clinton H., Bryksin, Janetta, Francis, Richard O., Lough, Christopher M., Patel, Niren, Kutlar, Abdullah, Josephson, Cassandra D., Roback, John D., Stowell, Sean R., Fasano, Ross M.

“…Background Post‐transfusion survival of donor red blood cells (RBCs) is important for effective chronic transfusion therapy in conditions including sickle cell…”
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Characteristics and potential biomarkers of adult sickle cell patients with chronic pain by Albo, Camila, Kumar, Sanjiv, Pope, Michael, Kidwell, Kyle Michael, Xu, Hongyan, Bowman, Latanya, Wells, Leigh, Barrett, Nadine, Fields, Sabine, Bora, Pritam, Patel, Niren, Kutlar, Abdullah

“…Objectives In this study, we investigated the evolution of chronic pain in sickle cell patients (SCD) as an age‐dependent phenomenon and studied the frequency…”
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Characteristics and Potential Biomarkers of Adult Sickle Cell Patients with Chronic Pain by Albo, Camila, Kumar, Sanjiv, Pope, Michael, Kidwell, Kyle Michael, Patel, Niren, Wells, Leigh, Bowman, Latanya, Barrett, Nadine, Hongyan, Xu, Kutlar, Abdullah

“…A paradigm shift is occurring in our understanding of pain in patients with sickle cell disease (SCD). Vaso-occlusive episodes (VOEs) are crises of acute…”
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Coinheritance of Alpha-3.7 Deletion and Hb Questembert [131alpha-2 Tct > CCT](Ser131>Pro)] in an African American Patient Results in an Alpha Thalassemia Phenotype by Shakir, Asiya, Pace, Betty, Patel, Niren, Kutlar, Ferdane, Kutlar, Abdullah, Ameri, Afshin

“…Patients with Hemoglobin Questembert carry a Ser131Pro mutation in one of their alpha globin chains encoded by a TCT-CCT mutation of one of their alpha 2…”
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Characteristics and Potential Biomarkers for Chronic Pain in Patients with Sickle Cell Disease by Kuei, Nina, Patel, Niren, Xu, Hongyan, Wells, Leigh, Bowman, Latanya, Bora, Pritam, Natrajan, Kavita, Kutlar, Abdullah

“…Vaso-occlusive episodes (VOE) or pain crises are a hallmark of sickle cell disease (SCD), with increasing recognition that a significant portion of SCD…”
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Analytic Characteristics and Performance of Novel Immunoassay Point-of-Care Tests for Early Diagnosis of Sickle Cell Disease: A Systematic Review by Jaja, Cheedy, Edem-Hotah, Joseph, Shepherd, Joan, Patel, Niren, Xu, Hongyan, Gibson, Robert W.

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Diagnostic Challenges in a Low a2 β-Thalassemia Case by Patel, Niren, Dixon, Natalia, Zhuang, Lina, Bryant, Shanequa, Kutlar, Ferdane, Kutlar, Abdullah

“…Inheritance of two β-thal alleles results in transfusion dependent anemia, growth retardation, and skeletal abnormalities (β-thal major), whereas…”
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Characteristics of Sickle Cell Patients with Frequent ED Visits and Hospitalizations: Demographic, Clinical, Laboratory and Psycho-Social Aspects by Kidwell, Kyle Michael, Albo, Camila, Pope, Michael, Bowman, Latanya, Xu, Hongyan, Wells, Leigh, Barrett, Nadine, Fields, Sabine, Bora, Pritam, Patel, Niren, Allison, Amy, Kutlar, Abdullah

“…Vaso-occlusive episodes (VOE), are considered a hallmark of sickle cell disease (SCD), and account for >90% of health care encounters for this patient…”
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