Search Results - "Patel, Nipa"

Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance by Xu, Jingwen, Patel, Nipa H, Gewirtz, David A

“…Chemotherapy and radiation often induce a number of cellular responses, such as apoptosis, autophagy, and senescence. One of the major regulators of these…”
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The Roles of Autophagy and Senescence in the Tumor Cell Response to Radiation by Patel, Nipa H., Sohal, Sahib S., Manjili, Masoud H, Harrell, J. Chuck, Gewirtz, David A.

“…Radiation is a critical pillar in cancer therapeutics, exerting its anti-tumor DNA-damaging effects through various direct and indirect mechanisms. Radiation…”
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Influence of nonprotective autophagy and the autophagic switch on sensitivity to cisplatin in non-small cell lung cancer cells by Patel, Nipa H., Xu, Jingwen, Saleh, Tareq, Wu, Yingliang, Lima, Santiago, Gewirtz, David A.

“…Cisplatin sensitivity in p53 wt and p53 deficient lung cancer cells appears to be a consequence of whether the drug-induced autophagy is functionally…”
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Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy by Saleh, Tareq, Tyutyunyk-Massey, Liliya, Patel, Nipa H, Cudjoe, Jr, Emmanuel K, Alotaibi, Moureq, Gewirtz, David A

“…Autophagy and senescence, predominant responses that may dictate cell fate after chemotherapy or radiation, often occur in tandem. Cells in states of…”
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The BET inhibitor/degrader ARV-825 prolongs the growth arrest response to Fulvestrant + Palbociclib and suppresses proliferative recovery in ER-positive breast cancer by Finnegan, Ryan M, Elshazly, Ahmed M, Patel, Nipa H, Tyutyunyk-Massey, Liliya, Tran, Tammy H, Kumarasamy, Vishnu, Knudsen, Erik S, Gewirtz, David A

“…Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen…”
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Targeting Peroxisome Proliferator-Activated Receptor-α (PPAR- α) to reduce paclitaxel-induced peripheral neuropathy by Caillaud, Martial, Patel, Nipa H., White, Alyssa, Wood, Mackinsey, Contreras, Katherine M., Toma, Wisam, Alkhlaif, Yasmin, Roberts, Jane L., Tran, Tammy H., Jackson, Asti B., Poklis, Justin, Gewirtz, David A., Damaj, M. Imad

“…[Display omitted] •Already known: Paclitaxel, a widely used anti-cancer drug, is frequently associated with prolonged and severe peripheral neuropathies, with…”
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Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy by Curry, Zachary A, Wilkerson, Jenny L, Bagdas, Deniz, Kyte, S Lauren, Patel, Nipa, Donvito, Giulia, Mustafa, Mohammed A, Poklis, Justin L, Niphakis, Micah J, Hsu, Ku-Lung, Cravatt, Benjamin F, Gewirtz, David A, Damaj, M Imad, Lichtman, Aron H

“…Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended…”
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Differential Radiation Sensitivity in p53 Wild-Type and p53-Deficient Tumor Cells Associated with Senescence but not Apoptosis or (Nonprotective) Autophagy by Xu, Jingwen, Patel, Nipa H, Saleh, Tareq, Cudjoe, Emmanuel K, Alotaibi, Moureq, Wu, Yingliang, Lima, Santiago, Hawkridge, Adam M, Gewirtz, David A

“…Studies of radiation interaction with tumor cells often focus on apoptosis as an end point; however, clinically relevant doses of radiation also promote…”
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N‐acylethanolamine‐hydrolysing acid amidase: A new potential target to treat paclitaxel‐induced neuropathy by Toma, Wisam, Caillaud, Martial, Patel, Nipa H., Tran, Tammy H., Donvito, Giulia, Roberts, Jane, Bagdas, Deniz, Jackson, Asti, Lichtman, Aron, Gewirtz, David A., Makriyannis, Alexandros, Malamas, Michael S., Imad Damaj, M.

“…Background Although paclitaxel is an effective chemotherapeutic agent used to treat multiple types of cancer (e.g. breast, ovarian, neck and lung), it also…”
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A Fenofibrate Diet Prevents Paclitaxel-Induced Peripheral Neuropathy in Mice by Caillaud, Martial, Patel, Nipa H, Toma, Wisam, White, Alyssa, Thompson, Danielle, Mann, Jared, Tran, Tammy H, Roberts, Jane L, Poklis, Justin L, Bigbee, John W, Fang, Xianjun, Gewirtz, David A, Damaj, M Imad

“…Paclitaxel-induced peripheral neuropathy (PIPN) is a major adverse effect of this chemotherapeutic agent that is used in the treatment of a number of solid…”
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Autophagy and Senescence in Cancer Therapy by Patel, Nipa H, Bloukh, Sarah, Alwohosh, Enas, Alhesa, Ahmad, Saleh, Tareq, Gewirtz, David A

“…Tumor cells can undergo diverse responses to cancer therapy. While apoptosis represents the most desirable outcome, tumor cells can alternatively undergo…”
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Abstract 4278: A comparison of drug sensitivity in isogenic tumor cell lines confirms that cytoprotective autophagy confers intrinsic resistance to cisplatin by Xu, Jingwen, Patel, Nipa, Saleh, Tareq, Wu, Yingliang, Lima, Santiago, Gewirtz, David A.

“…Abstract Although autophagy inhibition often increases tumor cell sensitivity to chemotherapy and radiation, these observations do not provide definitive proof…”
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Abstract 1323: A p53-dependent switch between cytoprotective and nonprotective autophagy influences tumor cell sensitivity to cisplatin by Xu, Jingwen, Saleh, Tareq, Patel, Nipa, Wu, Yingliang, Lima, Santiago, Gewirtz, David

“…Abstract Autophagy is a multi-step, homeostatic process through which cells turnover dysfunctional organelles and proteins. Previous work in our laboratory has…”
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Protocols for treating patients with end‐stage renal disease: a survey of nephrology fellowships by Perry, Maureen Munnelly, Howell, Scott, Patel, Nipa

“…ABSTRACT Rationale/background Approximately 14% of Americans are living with chronic kidney disease (CKD). The prevalence of end‐stage renal disease (ESRD),…”
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Protocols for treating patients with end-stage renal disease: a survey of AEGD/GPR dental residencies by Howell, Scott, Perry, Maureen Munnelly, Patel, Nipa

“…ABSTRACT Rationale/Background Approximately 14% of Americans are living with chronic kidney disease (CKD). The prevalence of end stage renal disease (ESRD),…”
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Abstract 1326: Nonprotective autophagy fails to confer resistance to radiation by Xu, Jingwen, Cudjoe, Emmanuel Kenneth, Saleh, Tareq, Patel, Nipa, Alotaibi, Moureq, Wu, Yingliang, Lima, Santiago, Gewirtz, David

“…Abstract Radiation remains a predominant treatment option for advanced, inoperable lung cancer, however, resistance represents a major barrier against…”
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When Money Can’t Be Avoided: Helping Money Avoidant Widows Using the Changes and Grief Model (FTA Best Paper Award) by Biever, Deb Finnegan, Patel, Nipa, Agnew, Ashley, Kopp, Daniel, Krausman, Jodi, McCoy, Megan A

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Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways by Howard, Katherine M., Abdel-al, Mohammed, Ditmyer, Marcia, Patel, Nipa

“…Objectives This study was designed to investigate and characterize the ability of platelet-activating factor (PAF) to induce the expression of…”
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Socioeconomic determinants of regional differences in nutrtional status of children in India by Patel, Nipa

“…While India has experienced rapid economic development during the last few decades, the prevalence of undernutrition remains high and the prevalence of…”
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Optimal Preventive Maintenance Scheduling in Semiconductor Manufacturing Systems: Software Tool and Simulation Case Studies by Ramírez-Hernández, J A, Crabtree, J, Xiaodong Yao, Fernandez, E, Fu, M C, Janakiram, M, Marcus, S I, O'Connor, M, Patel, N

“…This paper presents the architecture and implementation of a preventive maintenance optimization software tool (PMOST), based on algorithms for the optimal…”
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