Search Results - "Patel, Nimesh S"

Undertaking a high stakes virtual OSCE ("VOSCE") during Covid-19 by Blythe, Jenny, Patel, Nimesh S A, Spiring, Will, Easton, Graham, Evans, Dason, Meskevicius-Sadler, Egle, Noshib, Hassan, Gordon, Heather

“…The Covid pandemic and associated lockdown forced medical schools globally not only to deliver emergency remote teaching, but to consider alternative methods…”
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Generation of endogenous hydrogen sulfide by cystathionine γ-lyase limits renal ischemia/reperfusion injury and dysfunction by Tripatara, Pinpat, SA Patel, Nimesh, Collino, Massimo, Gallicchio, Margherita, Kieswich, Julius, Castiglia, Sara, Benetti, Elisa, Stewart, Keith N, Brown, Paul AJ, Yaqoob, Mohammed M, Fantozzi, Roberto, Thiemermann, Christoph

“…The generation of endogenous hydrogen sulfide may either limit or contribute to the degree of tissue injury caused by ischemia/reperfusion. A total of 74 male…”
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Gender dimorphism of the cardiac dysfunction in murine sepsis: signalling mechanisms and age-dependency by Chen, Jianmin, Chiazza, Fausto, Collino, Massimo, Patel, Nimesh S A, Coldewey, Sina M, Thiemermann, Christoph

“…Development of cardiac dysfunction is associated with increased morbidity and mortality in patients with sepsis. Increasing evidence shows that gender…”
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Dexamethasone Ameliorates Renal Ischemia-Reperfusion Injury by KUMAR, Sanjeev, ALLEN, David A, KIESWICH, Julius E, PATEL, Nimesh S. A, HARWOOD, Steven, MAZZON, Emanuela, CUZZOCREA, Salvatore, RAFTERY, Martin J, THIEMERMANN, Christoph, YAQOOB, Muhammad M

“…In the setting of renal ischemia-reperfusion injury (IRI), the effect and mechanism of action of glucocorticoids are not well understood. In rat renal IRI, a…”
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Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo : Role for xanthine oxidoreductase by TRIPATARA, Pinpat, PATEL, Nimesh S. A, WEBB, Andrew, RATHOD, Krishnaraj, LECOMTE, Florence M. J, MAZZON, Emanuela, CUZZOCREA, Salvatore, YAQOOB, Mohammed M, AHLUWALIA, Amrita, THIEMERMANN, Christoph

“…In normal conditions, nitric oxide (NO) is oxidized to the anion nitrite, but in hypoxia, this nitrite may be reduced back to NO by the nitrite reductase…”
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Validation of a Deep Learning Algorithm for Continuous, Real-Time Detection of Atrial Fibrillation Using a Wrist-Worn Device in an Ambulatory Environment by Poh, Ming-Zher, Battisti, Anthony J, Cheng, Li-Fang, Lin, Janice, Patwardhan, Anil, Venkataraman, Ganesh S, Athill, Charles A, Patel, Nimesh S, Patel, Chinmay P, Machado, Christian E, Ellis, Jeffrey T, Crosson, Lori A, Tamura, Yuriko, Plowman, R Scooter, Turakhia, Mintu P, Ghanbari, Hamid

“…Wearable devices may be useful for identification, quantification and characterization, and management of atrial fibrillation (AF). To date, consumer…”
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Protective Role of Peroxisome Proliferator-activated Receptor-β/δ in Septic Shock by KAPOOR, Amar, SHINTANI, Yasunori, MOTA-FILIPE, Helder, YAQOOB, Muhammad M, SUZUKI, Ken, BAHRAMI, Soheyl, DESVERGNE, Béatrice, MITCHELL, Jane A, THIEMERMANN, Christoph, COLLINO, Massimo, OSUCHOWSKI, Marcin F, BUSCH, Daniel, PATEL, Nimesh S. A, SEPODES, Bruno, CASTIGLIA, Sara, FANTOZZI, Roberto, BISHOP-BAILEY, David

“…Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of…”
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The NLRP3 Inflammasome as a Novel Player of the Intercellular Crosstalk in Metabolic Disorders by Benetti, Elisa, Chiazza, Fausto, Patel, Nimesh S. A., Collino, Massimo

“…The combination of obesity and type 2 diabetes is a serious health problem, which is projected to afflict 300 million people worldwide by 2020. Both clinical…”
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Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin by Brines, Michael, Patel, Nimesh S.A, Villa, Pia, Brines, Courtenay, Mennini, Tiziana, De Paola, Massimiliano, Erbayraktar, Zubeyde, Erbayraktar, Serhat, Sepodes, Bruno, Thiemermann, Christoph, Ghezzi, Pietro, Yamin, Michael, Hand, Carla C, Xie, Qiao-wen, Coleman, Thomas, Cerami, Anthony

“…Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays a critical hormonal role regulating erythrocyte production as well as a…”
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Cerebellar stroke presenting with isolated dizziness: Brain MRI in 136 patients by Perloff, Michael D., MD, PhD, Patel, Nimesh S., MD, Kase, Carlos S., MD, Oza, Anuja U., MD, Voetsch, Barbara, Romero, Jose R., MD

“…Abstract Objective To evaluate occurrence of cerebellar stroke in Emergency Department (ED) presentations of isolated dizziness (dizziness with a normal exam…”
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Characterisation of cystathionine gamma-lyase/hydrogen sulphide pathway in ischaemia/reperfusion injury of the mouse kidney: An in vivo study by Tripatara, Pinpat, Patel, Nimesh S.A., Brancaleone, Vincenzo, Renshaw, Derek, Rocha, Joao, Sepodes, Bruno, Mota-Filipe, Helder, Perretti, Mauro, Thiemermann, Christoph

“…The generation of endogenous hydrogen sulphide may either limit or contribute to the degree of tissue injury caused by ischaemia/reperfusion injury. Here, we…”
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Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse by Coldewey, Sina M, Rogazzo, Mara, Collino, Massimo, Patel, Nimesh S A, Thiemermann, Christoph

“…Nuclear factor κB (NF-κB) plays a pivotal role in sepsis. Activation of NF-κB is initiated by the signal-induced ubiquitylation and subsequent degradation of…”
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Junctional Adhesion Molecule–C Mediates Leukocyte Infiltration in Response to Ischemia Reperfusion Injury by Scheiermann, Christoph, Colom, Bartomeu, Meda, Paolo, Patel, Nimesh S.A, Voisin, Mathieu-Benoit, Marrelli, Alessandra, Woodfin, Abigail, Pitzalis, Costantino, Thiemermann, Christoph, Aurrand-Lions, Michel, Imhof, Beat A, Nourshargh, Sussan

“…OBJECTIVE—Junctional adhesion molecule–C (JAM-C) is an adhesion molecule that has multiple roles in inflammation and vascular biology, but many aspects of its…”
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The Effect of β2-Adrenoceptor Agonists on Leucocyte-Endothelial Adhesion in a Rodent Model of Laparotomy and Endotoxemia by Bangash, Mansoor Nawaz, Abbott, Tom E. F., Patel, Nimesh S. A., Hinds, Charles Johnston, Thiemermann, Christoph, Pearse, Rupert Mark

“…Background: The β 2 -adrenoceptor agonist dopexamine may possess anti-inflammatory actions which could reduce organ injury during endotoxemia and laparotomy…”
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Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states by Madalli, Shimona, Beyrau, Martina, Whiteford, James, Duchene, Johan, Singh Nandhra, Inderpal, Patel, Nimesh S A, Motwani, Madhur P, Gilroy, Derek W, Thiemermann, Christoph, Nourshargh, Sussan, Scotland, Ramona S

“…Tissue infiltration by neutrophils during acute inflammatory states causes substantial tissue injury. While the magnitude of tissue neutrophil accumulation in…”
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Pharmacological preconditioning with erythropoietin attenuates the organ injury and dysfunction induced in a rat model of hemorrhagic shock by Nandra, Kiran K, Collino, Massimo, Rogazzo, Mara, Fantozzi, Roberto, Patel, Nimesh S A, Thiemermann, Christoph

“…Pre-treatment with erythropoietin (EPO) has been demonstrated to exert tissue-protective effects against 'ischemia-reperfusion'-type injuries. This protection…”
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Neutrophil elastase plays a non‐redundant role in remodeling the venular basement membrane and neutrophil diapedesis post‐ischemia/reperfusion injury by Voisin, Mathieu‐Benoit, Leoni, Giovanna, Woodfin, Abigail, Loumagne, Laure, Patel, Nimesh SA, Di Paola, Rosanna, Cuzzocrea, Salvatore, Thiemermann, Christoph, Perretti, Mauro, Nourshargh, Sussan

“…Ischemia/reperfusion (I/R) injury is a severe inflammatory insult associated with numerous pathologies, such as myocardial infarction, stroke and acute kidney…”
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2020 ACC Expert Consensus Decision Pathway for Anticoagulant and Antiplatelet Therapy in Patients With Atrial Fibrillation or Venous Thromboembolism Undergoing Percutaneous Coronary Intervention or With Atherosclerotic Cardiovascular Disease: A Report of the American College of Cardiology Solution Set Oversight Committee by Kumbhani, Dharam J, Cannon, Christopher P, Beavers, Craig J, Bhatt, Deepak L, Cuker, Adam, Gluckman, Ty J, Marine, Joseph E, Mehran, Roxana, Messe, Steven R, Patel, Nimesh S, Peterson, Benjamin E, Rosenfield, Kenneth, Spinler, Sarah A, Thourani, Vinod H

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Dopexamine can attenuate the inflammatory response and protect against organ injury in the absence of significant effects on hemodynamics or regional microvascular flow by Bangash, Mansoor N, Patel, Nimesh S A, Benetti, Elisa, Collino, Massimo, Hinds, Charles J, Thiemermann, Christoph, Pearse, Rupert M

“…The effects of dopexamine, a β2-agonist, on perioperative and sepsis-related hemodynamic, microvascular, immune, and organ dysfunction are controversial and…”
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Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the β-common receptor by Khan, Areeg I, Coldewey, Sina M, Patel, Nimesh S A, Rogazzo, Mara, Collino, Massimo, Yaqoob, Muhammed M, Radermacher, Peter, Kapoor, Amar, Thiemermann, Christoph

“…There is limited evidence that the tissue-protective effects of erythropoietin are mediated by a heterocomplex of the erythropoietin receptor and the β-common…”
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