Search Results - "Patel, Niki R."

Mild, Redox-Neutral Alkylation of Imines Enabled by an Organic Photocatalyst by Patel, Niki R, Kelly, Christopher B, Siegenfeld, Allison P, Molander, Gary A

“…An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst,…”
Get full text

Mechanistic Study of Silver-Catalyzed Decarboxylative Fluorination by Patel, Niki R, Flowers, Robert A

“…The silver-catalyzed fluorination of aliphatic carboxylic acids by Selectfluor in acetone/water provides access to fluorinated compounds under mild and…”
Get full text

Uncovering the Mechanism of the Ag(I)/Persulfate-Catalyzed Cross-Coupling Reaction of Arylboronic Acids and Heteroarenes by Patel, Niki R, Flowers, Robert A

“…The catalytic cross-coupling of arylboronic acids with pyridines through single-electron oxidation provides efficient access to substituted heterocycles…”
Get full text

O‑Benzyl Xanthate Esters under Ni/Photoredox Dual Catalysis: Selective Radical Generation and Csp3–Csp2 Cross-Coupling by Vara, Brandon A, Patel, Niki R, Molander, Gary A

“…Alkyl xanthate esters are perhaps best known for their use in deoxygenation chemistry. However, their use in cross-coupling chemistry has not been productive,…”
Get full text

Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp(3)-sp(2) Cross-Coupling by Tellis, John C, Kelly, Christopher B, Primer, David N, Jouffroy, Matthieu, Patel, Niki R, Molander, Gary A

“…The important role of transition metal-catalyzed cross-coupling in expanding the frontiers of accessible chemical territory is unquestionable. Despite…”
Get full text

Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp3–sp2 Cross-Coupling by Tellis, John C, Kelly, Christopher B, Primer, David N, Jouffroy, Matthieu, Patel, Niki R, Molander, Gary A

“…The important role of transition metal-catalyzed cross-coupling in expanding the frontiers of accessible chemical territory is unquestionable. Despite…”
Get full text

Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis by Patel, Niki R, Kelly, Christopher B, Jouffroy, Matthieu, Molander, Gary A

“…Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp3 –Csp2 bonds through the transfer of…”
Get full text

Aminomethylation of Aryl Halides Using α‑Silylamines Enabled by Ni/Photoredox Dual Catalysis by Remeur, Camille, Kelly, Christopher B, Patel, Niki R, Molander, Gary A

“…A protocol for the aminomethylation of aryl halides using α-silylamines via Ni/photoredox dual catalysis is described. The low oxidation potential of these…”
Get full text

Phenol Derivatives as Coupling Partners with Alkylsilicates in Photoredox/Nickel Dual Catalysis by Patel, Niki R, Molander, Gary A

“…Photoredox/nickel dual catalysis via single electron transmetalation allows coupling of Csp3 –Csp2 hybridized centers under mild conditions. A procedure for…”
Get full text

Design of an in vitro biocatalytic cascade for the manufacture of islatravir by Huffman, Mark A, Fryszkowska, Anna, Alvizo, Oscar, Borra-Garske, Margie, Campos, Kevin R, Canada, Keith A, Devine, Paul N, Duan, Da, Forstater, Jacob H, Grosser, Shane T, Halsey, Holst M, Hughes, Gregory J, Jo, Junyong, Joyce, Leo A, Kolev, Joshua N, Liang, Jack, Maloney, Kevin M, Mann, Benjamin F, Marshall, Nicholas M, McLaughlin, Mark, Moore, Jeffrey C, Murphy, Grant S, Nawrat, Christopher C, Nazor, Jovana, Novick, Scott, Patel, Niki R, Rodriguez-Granillo, Agustina, Robaire, Sandra A, Sherer, Edward C, Truppo, Matthew D, Whittaker, Aaron M, Verma, Deeptak, Xiao, Li, Xu, Yingju, Yang, Hao

“…Enzyme-catalyzed reactions have begun to transform pharmaceutical manufacturing, offering levels of selectivity and tunability that can dramatically improve…”
Get full text

Preparation of visible-light-activated metal complexes and their use in photoredox/nickel dual catalysis by Kelly, Christopher B, Patel, Niki R, Primer, David N, Jouffroy, Matthieu, Tellis, John C, Molander, Gary A

“…This protocol describes the synthesis of two photoredox catalysts, [Ir{dF(CF 3 ) 2 ppy} 2 (bpy)]PF 6 and [Ru(bpy) 3 ](PF 6 ) 2 , that are activated by visible…”
Get full text

Total Synthesis of Darobactin A by Nesic, Marko, Ryffel, David B., Maturano, Jonathan, Shevlin, Michael, Pollack, Scott R., Gauthier, Donald R., Trigo-Mouriño, Pablo, Zhang, Li-Kang, Schultz, Danielle M., McCabe Dunn, Jamie M., Campeau, Louis-Charles, Patel, Niki R., Petrone, David A., Sarlah, David

“…The collaborative total synthesis of darobactin A, a recently isolated antibiotic that selectively targets Gram-negative bacteria, has been accomplished in a…”
Get full text

Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone by Patel, Niki R., Nawrat, Christopher C., McLaughlin, Mark, Xu, Yingju, Huffman, Mark A., Yang, Hao, Li, Hongming, Whittaker, Aaron M., Andreani, Teresa, Lévesque, François, Fryszkowska, Anna, Brunskill, Andrew, Tschaen, David M., Maloney, Kevin M.

Get full text

Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade by Patel, Niki R., Huffman, Mark A., Wang, Xiao, Ding, Bangwei, McLaughlin, Mark, Newman, Justin A., Andreani, Teresa, Maloney, Kevin M., Johnson, Heather C., Whittaker, Aaron M.

“…A 5‐step enantioselective synthesis of the potent anti‐HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel…”
Get full text

Correction to “Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis” by Patel, Niki R, Kelly, Christopher B, Jouffroy, Matthieu, Molander, Gary A

Get full text

O -Benzyl Xanthate Esters under Ni/Photoredox Dual Catalysis: Selective Radical Generation and Csp 3 -Csp 2 Cross-Coupling by Vara, Brandon A, Patel, Niki R, Molander, Gary A

“…Alkyl xanthate esters are perhaps best known for their use in deoxygenation chemistry. However, their use in cross-coupling chemistry has not been productive,…”
Get full text

Correction to “Uncovering the Mechanism of the Ag(I)/Persulfate-Catalyzed Cross-Coupling Reaction of Arylboronic Acids and Heteroarenes” by Patel, Niki R, Flowers, Robert A

Get full text

Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020) by Patel, Niki R., Huffman, Mark A., Wang, Xiao, Ding, Bangwei, McLaughlin, Mark, Newman, Justin A., Andreani, Teresa, Maloney, Kevin M., Johnson, Heather C., Whittaker, Aaron M.

“…A ball‐and‐stick Houk‐style view of islatravir, the target of the total synthesis described in this work, is depicted in the cover image. Islatravir is on top…”
Get full text

Single-Electron Transmetalation via Photoredox/Nickel Dual Catalysis: Unlocking a New Paradigm for sp 3 –sp 2 Cross-Coupling by Tellis, John C., Kelly, Christopher B., Primer, David N., Jouffroy, Matthieu, Patel, Niki R., Molander, Gary A.

Get full text

Mechanistic studies of silver-catalyzed single electron oxidations by Patel, Niki R

“…Catalytic oxidations that proceed through single-electron transfers are emerging as important approaches towards the formation of C-C and C-F bonds in…”
Get full text