Search Results - "Patel, Niketa A"

Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury by Patel, Niketa A, Moss, Lauren Daly, Lee, Jea-Young, Tajiri, Naoki, Acosta, Sandra, Hudson, Charles, Parag, Sajan, Cooper, Denise R, Borlongan, Cesario V, Bickford, Paula C

“…Neuroinflammation is a common therapeutic target for traumatic brain injury (TBI) due to its contribution to delayed secondary cell death and has the potential…”
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Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans by Patel, Rekha S, Krause-Hauch, Meredith, Kenney, Kimbra, Miles, Shannon, Nakase-Richardson, Risa, Patel, Niketa A

“…More than 75% of traumatic brain injuries (TBIs) are mild (mTBI) and military service members often experience repeated combat-related mTBI. The chronic…”
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Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes by Lui, Ashley, Patel, Rekha S, Krause-Hauch, Meredith, Sparks, Robert P, Patel, Niketa A

“…Type 2 diabetes mellitus is a chronic metabolic disease with no cure. Adipose tissue is a major site of systemic insulin resistance. Sortilin is a central…”
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Identification of Sortilin Alternatively Spliced Variants in Mouse 3T3L1 Adipocytes by Lui, Ashley, Sparks, Robert, Patel, Rekha, Patel, Niketa A

“…Type 2 diabetes mellitus is a metabolic disorder defined by systemic insulin resistance. Insulin resistance in adipocytes, an important regulator of glucose…”
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Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model by Patel, Rekha S., Lui, Ashley, Hudson, Charles, Moss, Lauren, Sparks, Robert P., Hill, Shannon E., Shi, Yan, Cai, Jianfeng, Blair, Laura J., Bickford, Paula C., Patel, Niketa A.

“…Shifts in normal aging set stage for neurodegeneration and dementia affecting 1 in 10 adults. The study demonstrates that lncRNA GAS5 is decreased in aged and…”
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Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function by Kong, Xaioyuan, Patel, Niketa A., Chalfant, Charles E., Cooper, Denise R.

“…Abstract Background The function of exosomes, small extracellular vesicles (sEV) secreted from human adipose-derived stem cells (ADSC), is becoming…”
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Long Noncoding RNA GAS5 Contained in Exosomes Derived from Human Adipose Stem Cells Promotes Repair and Modulates Inflammation in a Chronic Dermal Wound Healing Model by Patel, Rekha S, Impreso, Sabrina, Lui, Ashley, Vidyarthi, Gitanjali, Albear, Paul, Patel, Niketa A

“…Chronic recalcitrant wounds result from delayed or slowed healing processes. Underlying inflammation is a substantial risk factor for impaired dermal wound…”
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Stabilization of lncRNA GAS5 by a Small Molecule and Its Implications in Diabetic Adipocytes by Shi, Yan, Parag, Sajan, Patel, Rekha, Lui, Ashley, Murr, Michel, Cai, Jianfeng, Patel, Niketa A

“…Long noncoding RNA (lncRNA) are regulatory RNAs >200 nt. We previously showed that lncRNA GAS5 decreases significantly in serum of type 2 diabetes mellitus…”
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Intranasal delivery of exosomes from human adipose derived stem cells at forty-eight hours post injury reduces motor and cognitive impairments following traumatic brain injury by Moss, Lauren D., Sode, Derek, Patel, Rekha, Lui, Ashley, Hudson, Charles, Patel, Niketa A., Bickford, Paula C.

“…The neuroprotective role of human adipose-derived stems cells (hASCs) has raised great interest in regenerative medicine due to their ability to modulate their…”
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Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus by Carter, Gay, Miladinovic, Branko, Patel, Achintya A., Deland, Lauren, Mastorides, Stephen, Patel, Niketa A.

“…Diabetes mellitus (DM), a metabolic disease, is characterized by impaired fasting glucose levels. Type 2 DM is adult onset diabetes. Long non-coding RNAs…”
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Clk/STY (cdc2-like kinase 1) and Akt regulate alternative splicing and adipogenesis in 3T3-L1 pre-adipocytes by Li, Pengfei, Carter, Gay, Romero, Jacqueline, Gower, Kathryn M, Watson, James, Patel, Niketa A, Cooper, Denise R

“…The development of adipocytes from their progenitor cells requires the action of growth factors signaling to transcription factors to induce the expression of…”
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Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles by Patel, Niketa A, Lui, Ashley, Trujillo, Andrea N, Motawe, Zeinab Y, Bader, Deena, Schuster, Jane, Burgess, Andrea, Alves, Natascha G, Jo, Michiko, Breslin, Jerome W

“…The goal of this study was to identify mediators in peri-lymphatic adipose tissue (PLAT) that are altered in obese versus lean Zucker rats, with focus on…”
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1966-P: Induction of Beige Adipocyte Markers in 3T3-L1 Cells by Clk1 and PKCbetaII Inhibitors by PATEL, ACHINTYA, DOBBINS, TRADD, KONG, SONYA, PATEL, NIKETA A., COOPER, DENISE R.

“…Excessive dietary intake of fat results in its storage in white adipose tissue (WAT), whereas energy expenditure by lipid oxidation occurs in brown adipose…”
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MALAT1 in human adipose stem cells modulates survival and alternative splicing of PKCδII in HT22 cells by El Bassit, Ghattas, Patel, Rekha S, Carter, Gay, Shibu, Vyshakh, Patel, Achintya, Song, Shijie, Murr, Michel, Cooper, Denise R, Bickford, Paula C, Patel, Niketa A

“…Brain injury may be caused by trauma or may occur in stroke and neurodegenerative diseases. Since the central nervous system is unable to regenerate…”
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Multilevel Regulation of Protein Kinase CδI Alternative Splicing by Lithium Chloride by Bader, Deena, Patel, Rekha S., Lui, Ashley, Thawani, Chetna, Rupani, Rea, Vidyarthi, Gitanjali, Patel, Niketa A.

“…Lithium chloride (LiCl) is commonly used in treatment of mood disorders; however, its usage leads to weight gain, which promotes metabolic disorders. Protein…”
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A specific small-molecule inhibitor of protein kinase CδI activity improves metabolic dysfunction in human adipocytes from obese individuals by Sparks, Robert, Lui, Ashley, Bader, Deena, Patel, Rekha, Murr, Michel, Guida, Wayne, Fratti, Rutilio, Patel, Niketa A.

“…The metabolic consequences and sequelae of obesity promote life-threatening morbidities. PKCδI is an important elicitor of inflammation and apoptosis in…”
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Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules by Patel, Achintya, Dobbins, Tradd, Kong, Xiaoyuan, Patel, Rehka, Carter, Gay, Harding, Linette, Sparks, Robert P., Patel, Niketa A., Cooper, Denise R.

“…Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue…”
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Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPARγ2 Splicing during Adipogenesis in 3T3-L1 Cells by Cooper, Denise R, Carter, Gay, Li, Pengfei, Patel, Rehka, Watson, James E, Patel, Niketa A

“…Long non-coding (lnc) RNAs serve a multitude of functions in cells. NEAT1 RNA is a highly abundant 4 kb lncRNA in nuclei, and coincides with paraspeckles,…”
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Insulin Promotes Neuronal Survival via the Alternatively Spliced Protein Kinase CδII Isoform by Apostolatos, André, Song, Shijie, Acosta, Sandra, Peart, Mishka, Watson, James E., Bickford, Paula, Cooper, Denise R., Patel, Niketa A.

“…Insulin signaling pathways in the brain regulate food uptake and memory and learning. Insulin and protein kinase C (PKC) pathways are integrated and function…”
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Long Non-Coding RNA NEAT1 Associates with SRp40 to Temporally Regulate PPAR gamma 2 Splicing during Adipogenesis in 3T3-L1 Cells by Cooper, Denise R, Carter, Gay, Li, Pengfei, Patel, Rehka, Watson, James E, Patel, Niketa A

“…Long non-coding (lnc) RNAs serve a multitude of functions in cells. NEAT1 RNA is a highly abundant 4 kb lncRNA in nuclei, and coincides with paraspeckles,…”
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