Satellite Epidemic of Covid-19 Associated Mucormycosis in India: A Multi-Site Observational Study

Background Sudden upsurge in cases of COVID-19 Associated Mucormycosis (CAM) following the second wave of the COVID-19 pandemic was recorded in India. This study describes the clinical characteristics, management and outcomes of CAM cases, and factors associated with mortality. Methods Microbiologic...

Full description

Saved in:

Bibliographic Details
Published in:	Mycopathologia (1975) Vol. 188; no. 5; pp. 745 - 753
Main Authors:	Satija, Aanchal, Anand, Tanu, Mukherjee, Aparna, Velamuri, Poonam Sharma, Singh, Kh. Jitenkumar, Das, Madhuchhanda, Josten, Kripa, Keche, Archana Y., Nagarkar, Nitin M., Gupta, Prashant, Himanshu, D., Mistry, Sejal N., Patel, Jimy D., Rao, Prajwal, Rohatgi, Shalesh, Ghosh, Soumitra, Hazra, Avijit, Kindo, Anupma Jyoti, Annamalai, Radha, Rudramurthy, Shivaprakash M., Singh, Mini P., Shameem, Mohammad, Fatima, Nazish, Khambholja, Janakkumar R., Parikh, Sangita, Madkaikar, Manisha, Pradhan, Vandana D., Bhargava, Anudita, Mehata, Rupa, Arora, Ripu Daman, Tigga, Richa, Banerjee, Gopa, Sonkar, Vijay, Malhotra, Hardeep Singh, Kumar, Neeraj, Patil, Rajashri, Raut, Chandrashekhar G., Bhattacharyya, Kumkum, Arthur, Preetam, Somu, L., Srikanth, Padma, Shah, Pankaj B., Panda, Naresh K., Sharma, Dipti, Hasan, Wasil, Ahmed, Aftab, Bathla, Meeta, Solanki, Sunita, Doshi, Hiren, Kanani, Yash, Patel, Nishi, Shah, Zincal, Tembhurne, Alok Kumar, Rajguru, Chhaya, Sankhe, Lalitkumar R., Chavan, Shrinivas S., Yadav, Reetika Malik, Panda, Samiran
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-10-2023 Springer Springer Nature B.V
Subjects:	Analysis Biomedical and Life Sciences COVID-19 Diagnosis Eukaryotic Microbiology Fungal infections Glycosylated hemoglobin Health aspects Life Sciences Medical Microbiology Microbial Ecology Microbiology Mortality Mucormycosis Observational studies Original Article Patients Plant Sciences Posaconazole India Second wave Pandemic SARS-CoV 2 Diabetes mellitus Mortality Fungal infection
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Background Sudden upsurge in cases of COVID-19 Associated Mucormycosis (CAM) following the second wave of the COVID-19 pandemic was recorded in India. This study describes the clinical characteristics, management and outcomes of CAM cases, and factors associated with mortality. Methods Microbiologically confirmed CAM cases were enrolled from April 2021 to September 2021 from ten diverse geographical locations in India. Data were collected using a structured questionnaire and entered into a web portal designed specifically for this investigation. Bivariate analyses and logistic regression were conducted using R version 4.0.2. Results A total of 336 CAM patients were enrolled; the majority were male (n = 232, 69.1%), literate (n = 261, 77.7%), and employed (n = 224, 66.7%). The commonest presenting symptoms in our cohort of patients were oro-facial and ophthalmological in nature. The median (Interquartile Range; IQR) interval between COVID diagnosis and admission due to mucormycosis was 31 (18, 47) days, whereas the median duration of symptoms of CAM before hospitalization was 10 (5, 20) days. All CAM cases received antifungal treatment, and debridement (either surgical or endoscopic or both) was carried out in the majority of them (326, 97.02%). Twenty-three (6.9%) of the enrolled CAM cases expired. The odds of death in CAM patients increased with an increase in HbA1c level (aOR: 1.34, 95%CI: 1.05, 1.72) following adjustment for age, gender, education and employment status. Conclusion A longer vigil of around 4–6 weeks post-COVID-19 diagnosis is suggested for earlier diagnosis of CAM. Better glycemic control may avert mortality in admitted CAM cases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	0301-486X 1573-0832
DOI:	10.1007/s11046-023-00770-w