Search Results - "Patel, Jeegar"

Radiological evaluation of OrthAlign-A novel handheld navigation system used in total knee replacement by Patel, Jeegar, Yadav, Krishan, Daga, Rohit, Sadaria, Mohan

“…Background: The goal of this research is to determine how well OrthAlign, a novel portable navigation system for total knee replacement, helps surgeons make…”
Get full text

Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors by Olszewski, Kellen, Barsotti, Anthony, Feng, Xiao-Jiang, Momcilovic, Milica, Liu, Kevin G, Kim, Ji-In, Morris, Koi, Lamarque, Christophe, Gaffney, Jack, Yu, Xuemei, Patel, Jeegar P, Rabinowitz, Joshua D, Shackelford, David B, Poyurovsky, Masha V

“…Efforts to target glucose metabolism in cancer have been limited by the poor potency and specificity of existing anti-glycolytic agents and a poor…”
Get more information

Functional antibody characterization via direct structural analysis and information‐driven protein–protein docking by Depetris, Rafael S., Lu, Dan, Polonskaya, Zhanna, Zhang, Zhikai, Luna, Xenia, Tankard, Amari, Kolahi, Pegah, Drummond, Michael, Williams, Chris, Ebert, Maximilian C. C. J. C., Patel, Jeegar P., Poyurovsky, Masha V.

“…Detailed description of the mechanism of action of the therapeutic antibodies is essential for the functional characterization and future optimization of…”
Get full text

Outcome of single stage anterior and posterior surgery for tuberculous paraplegia by Yadav, Krishan, Mohan, Patel, Daga, Rahul, Sadaria, Mohan

“…Background: Morbidity and mortality from tuberculosis, a significant infectious illness, are expected to rise worldwide. The projected number of new cases rose…”
Get full text

Discovery and Optimization of Glucose Uptake Inhibitors by Liu, Kevin G, Kim, Ji-In, Olszewski, Kellen, Barsotti, Anthony M, Morris, Koi, Lamarque, Christophe, Yu, Xuemei, Gaffney, Jack, Feng, Xiao-Jiang, Patel, Jeegar P, Poyurovsky, Masha V

“…Aerobic glycolysis, originally identified by Warburg as a hallmark of cancer, has recently been implicated in immune cell activation and growth. Glucose, the…”
Get full text

A Phase 1 Thorough QT/QTc Study of Therapeutic and Supratherapeutic Doses of Belumosudil in Healthy Subjects by Schueller, Olivier, Lohmer, Lauren, Xue, Hongqi, Darpo, Borje, Patel, Jeegar

“…Belumosudil is a selective Rho‐associated, coiled‐coil‐containing protein kinase‐2 inhibitor. In this crossover design thorough QT/QTc study, single…”
Get full text

Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects by Schueller, Olivier, McDermott, John, Evans, Phil, Lohmer, Lauren, Alabanza, Anginelle, Patel, Jeegar

“…Belumosudil is a selective Rho‐associated coiled‐coil containing protein kinase 2 inhibitor. A capsule formulation was used during early clinical development…”
Get full text

Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14C]‐Belumosudil in Healthy Men: A Phase 1, Open‐Label, 2‐Part Study by Schueller, Olivier, Skucas, Ed, Regev, Galit, Shaw, Iain, Singh, Nand, Sanghvi, Mitesh, Croft, Marie, Lohmer, Lauren, Alabanza, Anginelle, Patel, Jeegar

“…Belumosudil is a selective Rho‐associated coiled‐coil containing protein kinase 2 (ROCK2) inhibitor. ROCK2 has been shown to drive proinflammatory response and…”
Get full text

652 Anti-PD-L1/IL-15 KD033 activated macrophages and induced anti-tumor immunity in the tumor-microenvironment by Martomo, Stella, Wang, George, Polonskaya, Zhanna, Luna, Xenia, Lu, Dan, Patel, Jeegar

“…BackgroundKD033 is a clinical-stage bispecific fusion molecule consisting of a high-affinity anti-human-PD-L1 antibody and human IL-15. Previous studies with…”
Get full text

573 A novel human anti-PD1/IL15 bi-functional protein with robust anti-tumor activity and low systemic toxicity by Lu, Dan, Polonskaya, Zhanna, Chang, Tzu-Pei, Martomo, Stella, Luna, Xenia, Zhang, Zhikai, Ng, Stanley, Miyara, Faical, Patel, Jeegar

“…BackgroundIL-15 is a key cytokine promoting CD8+ T, NK, and NKT cell proliferation and has demonstrated clinical activity in cancer patients without evidence…”
Get full text

512 Phase I dose escalation of KD033, a PDL1-IL15 bispecific molecule, in metastatic and advanced solid tumors by Luke, Jason, Olszanski, Anthony, Puzanov, Igor, Fountzilas, Christos, Rosen, Lee, Lu, Dan, Hackett, Adrian, Martomo, Stella, Schueller, Olivier, Eiznhamer, David, Mora, Alessandro, Ross, Miranda, Patel, Jeegar

“…BackgroundWhile IL-2 and IL-15 signal through the shared IL-2/15 βγ receptor, IL-15 does not directly expand regulatory T cells (Tregs)or mediate…”
Get full text

Modulation of neuronal CXCR4 by the μ-opioid agonist DAMGO by Patel, Jeegar P, Sengupta, Rajarshi, Bardi, Giuseppe, Khan, Muhammad Z, Mullen-Przeworski, Anna, Meucci, Olimpia

“…The chemokine receptor CXCR4 regulates neuronal survival and differentiation and is involved in a number of pathologies, including cancer and human…”
Get full text

Transcriptional profiling of primary human-skin derived mast cell activation by various MRGPRX2 agonists and inhibition with EVO756 by Bagchi, Sreya, Patel, Jeegar, Harden, Jamie

“…Abstract Mas-related G-protein coupled receptor X2 (MRGPRX2) is a GPCR expressed predominantly by mast cells and has been implicated to play an important role…”
Get full text

Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization by Bardi, Giuseppe, Sengupta, Rajarshi, Khan, Muhammad Z, Patel, Jeegar P, Meucci, Olimpia

“…The chemokine receptor CXCR4 functions as human immunodeficiency virus (HIV)-1 coreceptor and is involved in acquired immunodeficiency virus (AIDS)…”
Get full text

Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis by Khan, Muhammad Z, Brandimarti, Renato, Patel, Jeegar P, Huynh, Nha, Wang, Jun, Huang, Ziwei, Fatatis, Alessandro, Meucci, Olimpia

“…CXCR4, the specific receptor for the chemokine SDF-1 alpha that also binds CXCR4-using HIV gp120s, affects survival of different cell types, including neurons…”
Get more information

Efficacy of a novel oral, potent, and highly selective PKCt inhibitor in the SCID T-cell transfer colitis model by Harden, Jamie, Whitener, Robert, Kim, Andrea, Hofland, Hans, Patel, Jeegar

“…Abstract Protein kinase C family theta isoform (PKCt) is a key kinase downstream of T-cell receptor (TCR) and CD28 co-signaling in T-cells, leading to T-cell…”
Get full text

Selective small-molecule PKC-theta inhibitors effectively block TCR-mediated activation of naïve peripheral blood and tissue resident memory T cells by Whitener, Robert, Harden, Jamie, Hofland, Hans, Patel, Jeegar

“…Abstract Immune mediated inflammatory diseases constitute a diverse set of illnesses in which an aberrant immune response damages self-tissue. While progress…”
Get full text

Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo by Martomo, Stella A., Patel, Jeegar

“…KD033 is a clinical-stage immunocytokine composed of a high-affinity anti-human-PD-L1 antibody and the human IL-15/ IL-15 receptor sushi-domain complex. We…”
Get full text

ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease by Jagasia, Madan, Lazaryan, Aleksandr, Bachier, Carlos R, Salhotra, Amandeep, Weisdorf, Daniel J, Zoghi, Behyar, Essell, James, Green, Laurie, Schueller, Olivier, Patel, Jeegar, Zanin-Zhorov, Alexandra, Weiss, Jonathan M, Yang, Zhongming, Eiznhamer, David, Aggarwal, Sanjay K, Blazar, Bruce R, Lee, Stephanie J

“…The rho-associated coiled-coil-containing protein kinase-2 (ROCK2) signaling pathway regulates the Th17/regulatory T cells balance and controls profibrotic…”
Get full text

Efficacy of KD033, an anti-human-PD-L1-IL-15 bispecific protein, in human-PD-L1 positive and negative murine tumor models by Martomo, Stella, Lu, Dan, Polonskaya, Zhanna, Luna, Xenia, Zhang, Zhikai, Regev, Galit, Schueller, Olivier, Patel, Jeegar

“…Abstract only e14556 Background: KD033 is a clinical-stage bispecific fusion molecule consisting of a high-affinity anti-human-PD-L1 antibody and human IL-15…”
Get full text