Search Results - "Patel, Girishchandra B."

Role of macrophages in early host resistance to respiratory Acinetobacter baumannii infection by Qiu, Hongyu, KuoLee, Rhonda, Harris, Greg, Van Rooijen, Nico, Patel, Girishchandra B, Chen, Wangxue

“…Acinetobacter baumannii is an emerging bacterial pathogen that causes nosocomial pneumonia and other infections. Although it is recognized as an increasing…”
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Induction of mucosal immunity through systemic immunization: Phantom or reality? by Su, Fei, Patel, Girishchandra B., Hu, Songhua, Chen, Wangxue

“…Generation of protective immunity at mucosal surfaces can greatly assist the host defense against pathogens which either cause disease at the mucosal…”
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A Mouse Model of Acinetobacter baumannii-Associated Pneumonia Using a Clinically Isolated Hypervirulent Strain by HARRIS, Greg, RHONDA KUO LEE, LAM, Christopher K, KANZAKI, Gregory, PATEL, Girishchandra B, XU, H. Howard, WANGXUE CHEN

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Intestinal M cells： The fallible sentinels by Miller, Harvey, Zhang, Jianbing, Kuolee, Rhonda, Patel, Girishchandra B, Chen, Wangxue

“…The gastrointestinal tract represents the largest mucosal membrane surface in the human body. The immune system in the gut is the first line of host defense…”
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Acinetobacter baumannii infection inhibits airway eosinophilia and lung pathology in a mouse model of allergic asthma by Qiu, Hongyu, Kuolee, Rhonda, Harris, Greg, Zhou, Hongyan, Miller, Harvey, Patel, Girishchandra B, Chen, Wangxue

“…Allergic asthma is a dysregulation of the immune system which leads to the development of Th2 responses to innocuous antigens (allergens). Some infections and…”
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Intranasal immunization with an archaeal lipid mucosal vaccine adjuvant and delivery formulation protects against a respiratory pathogen challenge by Patel, Girishchandra B, Zhou, Hongyan, Ponce, Amalia, Harris, Greg, Chen, Wangxue

“…Archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) is a safe mucosal adjuvant that elicits long lasting and memory boostable mucosal and systemic…”
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Recent advances in the development of novel mucosal adjuvants and antigen delivery systems by Chen, Wangxue, Patel, Girishchandra B., Yan, Hongbin, Zhang, Jianbing

“…Mucosal infections and associated diseases remain a major socio-economic burden to society. Since parenteral immunizations fail to induce efficient protective…”
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Safety of Intranasally Administered Archaeal Lipid Mucosal Vaccine Adjuvant and Delivery (AMVAD) Vaccine in Mice by Patel, Girishchandra B., Ponce, Amalia, Zhou, Hongyan, Chen, Wangxue

“…The safety profile of a recently described novel archaeal lipid mucosal vaccine adjuvant and delivery (AMVAD) system capable of eliciting robust…”
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Intranasal immunization protects against Acinetobacter baumannii -associated pneumonia in mice by KuoLee, Rhonda, Harris, Greg, Yan, Hongbin, Xu, H. Howard, Conlan, Wayne J, Patel, Girishchandra B, Chen, Wangxue

“…Highlights • Intranasal immunization protects mice against lethal respiratory Acinetobacter baumannii infection. • Immunization limits bacterial extrapulmonary…”
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The Potent Adjuvant Activity of Archaeosomes Correlates to the Recruitment and Activation of Macrophages and Dendritic Cells In Vivo by Krishnan, Lakshmi, Sad, Subash, Patel, Girishchandra B, Sprott, G. Dennis

“…The unique glycerolipids of Archaea can be formulated into vesicles (archaeosomes) with potent adjuvant activity. We studied the effect of archaeosomes on APCs…”
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Mucosal and systemic immune responses by intranasal immunization using archaeal lipid-adjuvanted vaccines by Patel, Girishchandra B, Zhou, Hongyan, Ponce, Amalia, Chen, Wangxue

“…Abstract The utility of archaeal polar lipids as an adjuvant/delivery system for elicitation of antigen-specific mucosal immune responses in intranasally…”
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3′,5′-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection by Yan, Hongbin, KuoLee, Rhonda, Tram, Kha, Qiu, Hongyu, Zhang, Jianbing, Patel, Girishchandra B., Chen, Wangxue

“…3′,5′-Cyclic diguanylic acid (cdiGMP) is emerging as a universal bacterial second messenger in regulating bacterial growth on surfaces. It has been recently…”
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Archaeal lipid mucosal vaccine adjuvant and delivery system by Patel, Girishchandra B, Chen, Wangxue

“…Archaeal polar lipids are being evaluated as adjuvants/vaccine delivery systems for mucosal vaccines that can provide protection against pathogens that enter…”
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Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen by Sprott, G Dennis, Sad, Subash, Fleming, L Perry, Dicaire, Chantal J, Patel, Girishchandra B, Krishnan, Lakshmi

“…Archaeosomes prepared from total polar lipids extracted from six archaeal species with divergent lipid compositions had the capacity to deliver antigen for…”
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Cell surface glycoproteins from Thermoplasma acidophilum are modified with an N-linked glycan containing 6-C-sulfofucose by Vinogradov, Evgeny, Deschatelets, Lise, Lamoureux, Marc, Patel, Girishchandra B, Tremblay, Tammy-Lynn, Robotham, Anna, Goneau, Marie-France, Cummings-Lorbetskie, Cathy, Watson, David C, Brisson, Jean-Robert, Kelly, John F, Gilbert, Michel

“…Thermoplasma acidophilum is a thermoacidophilic archaeon that grows optimally at pH 2 and 59°C. This extremophile is remarkable by the absence of a cell wall…”
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Archaeosomes induce enhanced cytotoxic T lymphocyte responses to entrapped soluble protein in the absence of interleukin 12 and protect against tumor challenge by KRISHNAN, Lakshmi, SAD, Subash, PATEL, Girishchandra B, SPROTT, G. Dennis

“…Archaeosome adjuvants formulated as archaeal ether glycerolipid vesicles induce strong CD4(+) as well as CD8(+) CTL responses to entrapped soluble antigens…”
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Archaeobacterial ether lipid liposomes as vaccine adjuvants by Sprott, G Dennis, Patel, Girishchandra B, Krishnan, Lakshmi

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Archaeosome Vaccine Adjuvants Induce Strong Humoral, Cell-Mediated, and Memory Responses: Comparison to Conventional Liposomes and Alum by KRISHNAN, L, DICAIRE, C. J, PATEL, G. B, SPROTT, G. D

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Archaeosomes Induce Long-Term CD8+ Cytotoxic T Cell Response to Entrapped Soluble Protein by the Exogenous Cytosolic Pathway, in the Absence of CD4+ T Cell Help by Krishnan, Lakshmi, Sad, Subash, Patel, Girishchandra B, Sprott, G. Dennis

“…The unique ether glycerolipids of Archaea can be formulated into vesicles (archaeosomes) with strong adjuvant activity for MHC class II presentation. Herein,…”
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Safety Evaluation of Calcium Administered Intranasally to Mice by Patel, Girishchandra B., Zhou, Hongyan, Ponce, Amalia, Chen, Wangxue

“…Calcium, a component of approved human vaccines administered via systemic routes, has a good safety profile. Recently, intranasally administered vaccines…”
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