Search Results - "Patel, Dinesh V"

Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor by Chen, Dawn Z, Patel, Dinesh V, Hackbarth, Corinne J, Wang, Wen, Dreyer, Geoffrey, Young, Dennis C, Margolis, Peter S, Wu, Charlotte, Ni, Zi-Jie, Trias, Joaquim, White, Richard J, Yuan, Zhengyu

“…Peptide deformylase (PDF) is essential in prokaryotes and absent in mammalian cells, thus making it an attractive target for the discovery of novel…”
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Approaches to Combinatorial Synthesis of Heterocycles:  A Solid-Phase Synthesis of 1,4-Dihydropyridines by Gordeev, Mikhail F, Patel, Dinesh V, Gordon, Eric M

“…N-Immobilized enamino esters 2 derived from amine-functionalized PAL or Rink polystyrene resins react with preformed 2-arylidene β-keto esters or directly with…”
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N-Alkyl Urea Hydroxamic Acids as a New Class of Peptide Deformylase Inhibitors with Antibacterial Activity by HACKBARTH, Corinne J, CHEN, Dawn Z, LOPEZ, S, WITHERS, George III, GU, Helen, DUNN, Elina, KULATHILA, R, PAN, Shi-Hao, PORTER, Wilma L, JACOBS, Jeff, TRIAS, Joaquim, PATEL, Dinesh V, LEWIS, Jason G, WEIDMANN, Beat, WHITE, Richard J, ZHENGYU YUAN, CLARK, Kirk, MANGOLD, James B, CRAMER, Jeffrey A, MARGOLIS, Peter S, WEN WANG, KOEHN, Jim, WU, Charlotte

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetics and Pharmacodynamics of AR9281, an Inhibitor of Soluble Epoxide Hydrolase, in Single- and Multiple-Dose Studies in Healthy Human Subjects by Chen, Dawn, Whitcomb, Randall, MacIntyre, Euan, Tran, Vinh, Do, Zung N., Sabry, James, Patel, Dinesh V., Anandan, Sampath K., Gless, Richard, Webb, Heather K.

“…AR9281, a potent and selective inhibitor of soluble epoxide hydrolase (s-EH), is in clinical development targeting hypertension and type 2 diabetes. The…”
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Selective Solid Phase Synthesis of Ureas and Hydantoins from Common Phenyl Carbamate Intermediates by Xiao, Ngu, Khehyong, Chao, Corinne, Patel, Dinesh V

“…An efficient method for selective, solid phase synthesis of unsymmetrical ureas and hydantoins from a common phenyl carbamate dipeptide intermediate is…”
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alpha.-Hydroxy Phosphinyl-Based Inhibitors of Human Renin by Patel, Dinesh V, Rielly-Gauvin, Katherine, Ryono, Denis E, Free, Charles A, Rogers, W. Lynn, Smith, Sandra A, DeForrest, Jack M, Oehl, Robert S, Petrillo, Edward W

“…The design and application of alpha-hydroxy phosphonates, a new class of transition state analogs, toward the discovery of novel and potent inhibitors of the…”
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N- and C-terminal modifications of negamycin by Raju, B, Mortell, Kathleen, Anandan, Sampathkumar, O'Dowd, Hardwin, Gao, Hongwu, Gomez, Marcela, Hackbarth, Corinne, Wu, Charlotte, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim, Patel, Dinesh V

“…Negamycin 1 is a bactericidal antibiotic with activity against Gram-negative bacteria, and served as a template in an antibiotic discovery program. An…”
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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia by Anandan, Sampath-Kumar, Webb, Heather Kay, Chen, Dawn, Wang, Yi-Xin (Jim), Aavula, Basker R., Cases, Sylvaine, Cheng, Ying, Do, Zung N., Mehra, Upasana, Tran, Vinh, Vincelette, Jon, Waszczuk, Joanna, White, Kathy, Wong, Kenneth R., Zhang, Le-Ning, Jones, Paul D., Hammock, Bruce D., Patel, Dinesh V., Whitcomb, Randall, MacIntyre, D. Euan, Sabry, James, Gless, Richard

“…1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) attenuated the enhanced glucose excursion following an intraperitoneal glucose tolerance test and…”
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Rational Design and Combinatorial Evaluation of Enzyme Inhibitor Scaffolds:  Identification of Novel Inhibitors of Matrix Metalloproteinases by Szardenings, Anna Katrin, Harris, David, Lam, Stuart, Shi, Lihong, Tien, David, Wang, Yongwen, Patel, Dinesh V, Navre, Marc, Campbell, David A

“…The discovery of a novel series of heterocyclic matrix metalloproteinase (MMPs) inhibitors is described. Published crystal structures of peptidyl hydroxamates…”
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Discovery and Characterization of a Potent Interleukin-6 Binding Peptide with Neutralizing Activity In Vivo by Ranganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G, Liu, Guang, Tran, Tran T, Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E, Graul, Chris, Griffin, Aliesha, Schairer, Wayne C, Higgins, Carolyn, Reza, Tammi L, Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim, Mandyam, Ramya A, Masferrer, Jaime, Liu, David, Patel, Dinesh V, Fretzen, Angelika, Murphy, Craig A, Milne, G Todd, Smythe, Mark L, Carlson, Kenneth E

“…Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6…”
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Conformationally restricted analogs of deoxynegamycin by Raju, B., Anandan, Sampathkumar, Gu, Shihai, Herradura, Prudencio, O’Dowd, Hardwin, Kim, Bum, Gomez, Marcela, Hackbarth, Corinne, Wu, Charlotte, Wang, Wen, Yuan, Zhengyu, White, Richard, Trias, Joaquim, Patel, Dinesh V.

“…Methods were developed to synthesize a number of conformationally restricted β-amino acids. Incorporation of these β-amino acids into deoxynegamycin template…”
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Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase by Patel, Dinesh V, Schmidt, Robert J, Biller, Scott A, Gordon, Eric M, Robinson, Simon S, Manne, Veeraswamy

“…The rational design, synthesis, and biological activity of farnesyl diphosphate (FPP)-based inhibitors of the enzyme Ras farnesyl protein transferase (FPT) is…”
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Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors by Anandan, Sampath-Kumar, Do, Zung N., Webb, Heather K., Patel, Dinesh V., Gless, Richard D.

“…Inhibition of soluble epoxide hydrolase (sEH) has been proposed as a promising new pharmaceutical target for diseases involving hypertension and vascular…”
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Activated ketone based inhibitors of human renin by Patel, Dinesh V, Rielly-Gauvin, Katherine, Ryono, Denis E, Free, Charles A, Smith, Sandra A, Petrillo, Edward W

“…Application of the concept of activated ketones to the design of novel and potent transition-state analog inhibitors of the aspartyl protease renin is…”
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Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors by Anandan, Sampath-Kumar, Ward, John S., Brokx, Richard D., Denny, Trisha, Bray, Mark R., Patel, Dinesh V., Xiao, Xiao-Yi

“…The synthesis, histone deacetylase (HDAC) inhibitory activity and the antiproliferative activity of thiazole-5-hydroxamic acids 6– 9 are described. We have…”
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Conformational Constraint in Oxazolidinone Antibacterials. Synthesis and Structure−Activity Studies of (Azabicyclo[3.1.0]hexylphenyl)oxazolidinones by Renslo, Adam R, Jaishankar, Priyadarshini, Venkatachalam, Revathy, Hackbarth, Corinne, Lopez, Sara, Patel, Dinesh V, Gordeev, Mikhail F

“…The oxazolidinones are a new class of synthetic antibacterials effective against a broad range of pathogenic Gram-positive bacteria, including…”
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Novel oxazolidinone–quinolone hybrid antimicrobials by Gordeev, Mikhail F., Hackbarth, Corinne, Barbachyn, Michael R., Banitt, Lee S., Gage, James R., Luehr, Gary W., Gomez, Marcela, Trias, Joaquim, Morin, Sara E., Zurenko, Gary E., Parker, Christian N., Evans, Jonathan M., White, Richard J., Patel, Dinesh V.

“…Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2,…”
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Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors by Anandan, Sampath-Kumar, Ward, John S., Brokx, Richard D., Bray, Mark R., Patel, Dinesh V., Xiao, Xiao-Xi

“…The synthesis and histone deacetylase (HDAC) inhibitory activity of mercaptoamides 2 and 3 is described. Inhibitors of histone deacetylases (HDAC) are emerging…”
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A New and Efficient Solid Phase Synthesis of Hydroxamic Acids by Ngu, Khehyong, Patel, Dinesh V

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Synthesis and structure–activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings by Renslo, Adam R., Luehr, Gary W., Lam, Stuart, Westlund, Neil E., Gómez, Marcela, Hackbarth, Corrine J., Patel, Dinesh V., Gordeev, Mikhail F.

“…A new series of oxazolidinone analogs bearing unsaturated sulfur-containing C-rings is described. New synthetic approaches to the dihydrothiazine ring system…”
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