Search Results - "Patel, Chetan N"

Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease by Hipp, Mark S, Patel, Chetan N, Bersuker, Kirill, Riley, Brigit E, Kaiser, Stephen E, Shaler, Thomas A, Brandeis, Michael, Kopito, Ron R

“…Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington's disease, suggests that highly aggregated…”
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IL-33 released by alum is responsible for early cytokine production and has adjuvant properties by Rose II, William A., Okragly, Angela J., Patel, Chetan N., Benschop, Robert J.

“…Human vaccines have used aluminium-based adjuvants (alum) for >80 years despite incomplete understanding of how alum enhances the immune response. Alum can…”
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Binding, Neutralization and Internalization of the Interleukin-13 Antibody, Lebrikizumab by Okragly, Angela J., Ryuzoji, Aya, Wulur, Isabella, Daniels, Montanea, Van Horn, Robert D., Patel, Chetan N., Benschop, Robert J.

“…Introduction IL-13 is the primary upregulated cytokine in atopic dermatitis (AD) skin and is the pathogenic mediator driving AD pathophysiology. Lebrikizumab,…”
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Cell culture media impact on drug product solution stability by Purdie, Jennifer L., Kowle, Ronald L., Langland, Amie L., Patel, Chetan N., Ouyang, Anli, Olson, Donald J.

“…To enable subcutaneous administration of monoclonal antibodies, drug product solutions are often needed at high concentrations. A significant risk associated…”
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N+1 Engineering of an Aspartate Isomerization Hotspot in the Complementarity-Determining Region of a Monoclonal Antibody by Patel, Chetan N, Bauer, Scott P, Davies, Julian, Durbin, Jim D, Shiyanova, Tatiyana L, Zhang, Kai, Tang, Jason X

“…Aspartate (Asp) isomerization is a common degradation pathway and a potential critical quality attribute that needs to be well characterized during the…”
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FlgM Gains Structure in Living Cells by Dedmon, Matthew M., Patel, Chetan N., Young, Gregory B., Pielak, Gary J.

“…Intrinsically disordered proteins such as FlgM play important roles in biology, but little is known about their structure in cells. We use NMR to show that…”
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In vitro Generated Mesenchymal Stem Cells: Suitable Tools to Target Insulin Dependent Diabetes Mellitus? by Dave, Shruti D, Patel, Chetan N, Patel, Jignesh V, Thakkar, Umang G

“…A synergy of a pre-accumulated genes with an autoimmunity advancing to slow abolition of pancreatic beta-cells causes insulin deficiency and results enrooting…”
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In-vitro generation of interleukin-10 secreting B-regulatory cells from donor adipose tissue derived mesenchymal stem cells and recipient peripheral blood mononuclear cells for potential cell therapy by Gupte, Kunal S, Vanikar, Aruna V, Trivedi, Hargovind L, Patel, Chetan N, Patel, Jignesh V

“…Interleukin-10 secreting B-cells are a major subset of B-regulatory cells (B-regs), commonly recognized as CD19 /38 /24 /IL10 . They carry out immunomodulation…”
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In vitro differentiation of neural cells from human adipose tissue derived stromal cells by Dave, Shruti, Patel, Chetan, Vanikar, Aruna, Trivedi, Hargovind

“…Background: Stem cells, including neural stem cells (NSCs), are endowed with self-renewal capability and hence hold great opportunity for the institution of…”
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Generation and Characterization of Torudokimab (LY3375880): A Monoclonal Antibody That Neutralizes Interleukin-33 by Okragly, Angela J, Corwin, Katie Brannon, Elia, Marikka, He, Dongmei, Schroeder, Oliver, Zhang, Qing, Shiyanova, Tatiyana, Bright, Stuart, Dicker, Sarah B, Chlewicki, Lukasz, Truhlar, Stephanie ME, Davies, Julian, Patel, Chetan N, Benschop, Robert J

“…Background: Interleukin-33 (IL-33) is an alarmin that is released following cellular damage, mechanical injury, or necrosis. It is a member of the IL-1 family…”
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Asymmetric Binding Between SecA and SecB Two Symmetric Proteins: Implications for Function in Export by Randall, Linda L., Crane, Jennine M., Lilly, Angela A., Liu, Gseping, Mao, Chunfeng, Patel, Chetan N., Hardy, Simon J.S.

“…SecB, a small tetrameric chaperone in Escherichia coli, facilitates export of precursor polypeptides from the cytoplasm to the periplasmic space. During this…”
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Characterization of three areas of interactions stabilizing complexes between SecA and SecB, two proteins involved in protein export by Patel, Chetan N., Smith, Virginia F., Randall, Linda L.

“…The general secretory, Sec, system translocates precursor polypeptides from the cytosol across the cytoplasmic membrane in Escherichia coli. SecB, a small…”
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Stability and apoptotic activity of recombinant human cytochrome c by Olteanu, Alina, Patel, Chetan N, Dedmon, Matthew M, Kennedy, Scott, Linhoff, Michael W, Minder, Camille M, Potts, Patrick R, Deshmukh, Mohanish, Pielak, Gary J

“…An efficient system for producing human cytochrome c variants is important to help us understand the roles of this protein in biological processes relevant to…”
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Reconsideration of sedimentation equilibrium distributions reflecting the effects of small inert cosolutes on the dimerization of α-chymotrypsin by Winzor, Donald J., Patel, Chetan N., Pielak, Gary J.

“…A reported discrepancy between quantitative estimates of the extent of enhanced α-chymotrypsin dimerization in the presence of sucrose is traced to different…”
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Design of a Ruthenium-Labeled Cytochrome c Derivative to Study Electron Transfer with the Cytochrome bc1 Complex by ENGSTROM, Gregory, RAJAGUKGUK, Ray, SAUNDERS, Aleister J., PATEL, Chetan N., RAJAGUKGUK, Sany, MERBITZ-ZAHRADNIK, Torsten, XIAO, Kunhong, PIELAK, Gary J., TRUMPOWER, Bernard, YU, Chang-An, YU, Linda, DURHAM, Bill, MILLETT, Francis

“…A new ruthenium-cytochrome c derivative was designed to study electron transfer from cytochrome bc1 to cytochrome c (Cc). The single sulfhydryl on yeast…”
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Effects of molecular crowding by saccharides on α‐chymotrypsin dimerization by Patel, Chetan N., Noble, Schroeder M., Weatherly, Gresham T., Tripathy, Ashutosh, Winzor, Donald J., Pielak, Gary J.

“…Given the importance of protein complexes as therapeutic targets, it is necessary to understand the physical chemistry of these interactions under the crowded…”
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Design of a Ruthenium-Labeled Cytochrome c Derivative to Study Electron Transfer with the Cytochrome bc 1 Complex by Engstrom, Gregory, Rajagukguk, Ray, Saunders, Aleister J, Patel, Chetan N, Rajagukguk, Sany, Merbitz-Zahradnik, Torsten, Xiao, Kunhong, Pielak, Gary J, Trumpower, Bernard, Yu, Chang-An, Yu, Linda, Durham, Bill, Millett, Francis

“…A new ruthenium-cytochrome c derivative was designed to study electron transfer from cytochrome bc 1 to cytochrome c (Cc). The single sulfhydryl on yeast…”
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Generation and Characterization of Torudokimab by He, Dongmei, Patel, Chetan N, Davies, Julian, Benschop, Robert J, Shiyanova, Tatiyana, Zhang, Qing, Chlewicki, Lukasz, Corwin, Katie Brannon, Schroeder, Oliver, Elia, Marikka, Okragly, Angela J, Bright, Stuart, Dicker, Sarah B, Truhlar, Stephanie ME

“…Background: Interleukin-33 (IL-33) is an alarmin that is released following cellular damage, mechanical injury, or necrosis. It is a member of the IL-1 family…”
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Characterization of Horse Cytochrome c Expressed in Escherichia coli by Patel, Chetan N., Lind, Maria C., Pielak, Gary J.

“…We have expressed horse cytochrome c in Escherichia coli. The gene was designed with E. coli codon bias and assembled by using a recursive polymerase chain…”
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