Search Results - "Patel, Bhaumik B"

The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres by Kanwar, Shailender S, Yu, Yingjie, Nautiyal, Jyoti, Patel, Bhaumik B, Majumdar, Adhip P N

“…Recent evidence suggests that epithelial cancers, including colorectal cancer are driven by a small sub-population of self-renewing, multi-potent cells termed…”
Get full text

A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation by Boothello, Rio S, Patel, Nirmita J, Sharon, Chetna, Abdelfadiel, Elsamani I, Morla, Shravan, Brophy, Donald F, Lippman, H Robert, Desai, Umesh R, Patel, Bhaumik B

“…Targeting of cancer stem cells (CSC) is expected to be a paradigm-shifting approach for the treatment of cancers. Cell surface proteoglycans bearing sulfated…”
Get full text

A molecular dynamics-based algorithm for evaluating the glycosaminoglycan mimicking potential of synthetic, homogenous, sulfated small molecules by Nagarajan, Balaji, Sankaranarayanan, Nehru Viji, Patel, Bhaumik B, Desai, Umesh R

“…Glycosaminoglycans (GAGs) are key natural biopolymers that exhibit a range of biological functions including growth and differentiation. Despite this…”
Get full text

Curcumin enhances dasatinib‐induced inhibition of growth and transformation of colon cancer cells by Nautiyal, Jyoti, Banerjee, Sanjeev, Kanwar, Shailender S., Yu, Yingjie, Patel, Bhaumik B, Sarkar, Fazlul H., Majumdar, Adhip P.N.

“…Colorectal cancer is the third most common form of malignancy, behind prostate and lung cancers. Despite recent advances in medicine, mortality from colorectal…”
Get full text

Curcumin enhances the effects of 5‐fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF‐1R by Patel, Bhaumik B., Sengupta, Radha, Qazi, Sadia, Vachhani, Hetal, Yu, Yingjie, Rishi, Arun K., Majumdar, Adhip P.N.

“…Curcumin (diferuloylmethane), which has been shown to inhibit growth of transformed cells, has no discernible toxicity and achieves high levels in colonic…”
Get full text

High dose acetaminophen inhibits STAT3 and has free radical independent anti-cancer stem cell activity by Pingali, Pavani, Wu, Y. Jeffrey, Boothello, Rio, Sharon, Chetna, Li, Howard, Sistla, Srinivas, Sankaranarayanan, Nehru Viji, Desai, Umesh R., Le, Anh T., Doebele, Robert C., Muldoon, Leslie L., Patel, Bhaumik B., Neuwelt, Alexander

“…High-dose acetaminophen (AAP) with delayed rescue using n-acetylcysteine (NAC), the FDA-approved antidote to AAP overdose, has demonstrated promising antitumor…”
Get full text

Elimination of Colon Cancer Stem-Like Cells by the Combination of Curcumin and FOLFOX by Yu, Yingjie, Kanwar, Shailender S., Patel, Bhaumik B., Nautiyal, Jyoti, Sarkar, Fazlul H., Majumdar, Adhip P.N.

“…5-Fluorouracil (5-FU) or 5-FU plus oxaliplatin (FOLFOX) remains the backbone of colorectal cancer chemotherapeutics but with limited success. This could partly…”
Get full text

Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling by Nautiyal, Jyoti, Majumder, Pralay, Patel, Bhaumik B, Lee, Francis Y, Majumdar, Adhip P.N

“…Abstract EGF-receptor family members (EGFRs) as well as c-Src are over expressed in ∼70% of breast cancer, and in most of the tumors c-Src is co-over expressed…”
Get full text

Folic acid supplementation inhibits recurrence of colorectal adenomas： A randomized chemoprevention trial by Jaszewski, Richard, Misra, Sabeena, Tobi, Martin, Ullah, Nadeem, Naumoff, Jo Ann, Kucuk, Omer, Levi, Edi, Axelrod, Bradley N, Patel, Bhaumik B, Majumdar, Adhip P N

“…AIM： To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a…”
Get full text

A Strategic Approach to Identification of Selective Inhibitors of Cancer Stem Cells by Patel, Nirmita, Baranwal, Somesh, Patel, Bhaumik B

“…Cancer stem-like cells (CSC) have been implicated in resistance to conventional chemotherapy as well as invasion and metastasis resulting in tumor relapse in…”
Get more information

Senescence and castration resistance in prostate cancer: A review of experimental evidence and clinical implications by Carpenter, Valerie J., Patel, Bhaumik B., Autorino, Riccardo, Smith, Steven C., Gewirtz, David A., Saleh, Tareq

“…The development of Castration-Resistant Prostate Cancer (CRPC) remains a major challenge in the treatment of this disease. While Androgen Deprivation Therapy…”
Get full text

Optimization of Supercritical Fluid Extraction of Paprika (cv. Reshampatti) Oil, Capsaicin and Pigments by Shah, Nikunj A., Prasad, R.V., Patel, Bhaumik B.

“…Paprika (Capsicum annuum L.) is a spice, utilized in culinary across the globe for its colour and pungency. A study was conducted to optimize the supercritical…”
Get full text

MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells by Yu, Yingjie, Kanwar, Shailender S., Patel, Bhaumik B., Oh, Phil-Sun, Nautiyal, Jyoti, Sarkar, Fazlul H., Majumdar, Adhip P.N.

“…Although microRNA-21 (miR-21) is emerging as an oncogene and has been shown to target several tumor suppressor genes, including programmed cell death 4…”
Get full text

Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity by Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

“…Sulfated glycosaminoglycans (GAGs), or synthetic mimetics thereof, are not favorably viewed as orally bioavailable drugs owing to their high number of anionic…”
Get full text

Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor by Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

“…The insulin‐like growth factor‐1 receptor (IGF‐1R) is a receptor tyrosine kinase (RTK) that plays critical roles in cancer. Microarray, computational,…”
Get full text

Polymeric fluorescent heparin as one-step FRET substrate of human heparanase by Sistla, Jyothi C., Morla, Shravan, Alabbas, Al-Humaidi B., Kalathur, Ravi C., Sharon, Chetna, Patel, Bhaumik B., Desai, Umesh R.

“…•Development of polymeric heparin as a FRET substrate of heparanase.•The FRET substrate enables rapid, one-step screening of heparanase inhibitors.•The FRET…”
Get full text

Prevent Acute Chest Syndrome checklist (PACScheck): A quality improvement initiative to reduce acute chest syndrome by Morrone, Kerry, Strumph, Kaitlin, Pisacano, Catherine, Briggs, Jessica, Zipper, Rachelle, Patel, Bhaumik B, Chang, Susanna, Kyon, Wen-Ling, Ronca, Kristen, Abyazi, Miranda, Cheng, Geoffrey, Schwartz, Leya, Santos, Jennifer De Los, Keenan, Janine, Reznik, Marina, Manwani, Deepa, Rinke, Michael L

“…Acute chest syndrome (ACS) is a life-threatening complication of sickle cell disease (SCD). The Prevent Acute Chest Syndrome checklist (PACScheck) was created…”
Get full text

Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase by Patel, Nirmita J, Sharon, Chetna, Baranwal, Somesh, Boothello, Rio S, Desai, Umesh R, Patel, Bhaumik B

“…Heparan sulfate (HS) plays a role in the majority of essential hallmarks of cancer, yet its ability to modulate self-renewal, especially of cancer stem cells…”
Get full text

Difluorinated-Curcumin (CDF): A Novel Curcumin Analog is a Potent Inhibitor of Colon Cancer Stem-Like Cells by Kanwar, Shailender Singh, Yu, Yingjie, Nautiyal, Jyoti, Patel, Bhaumik B., Padhye, Subhash, Sarkar, Fazlul H., Majumdar, Adhip P. N.

“…ABSTRACT Purpose Recurrence of colon cancer, which affects nearly 50% of patients treated by conventional therapeutics, is thought to be due to re-emergence of…”
Get full text

Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells by Patel, Jagrut, Baranwal, Somesh, Love, Ian M, Patel, Nirmita J, Grossman, Steven R, Patel, Bhaumik B

“…Selective targeting of cancer stem cells (CSCs), implicated in tumor relapse, holds great promise in the treatment of colorectal cancer. Overexpression of…”
Get full text